1. Citriperazines A-D produced by a marine algae-derived fungus Penicillium sp. KMM 4672.
- Author
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Yurchenko AN, Berdyshev DV, Smetanina OF, Ivanets EV, Zhuravleva OI, Rasin AB, Khudyakova YV, Popov RS, Dyshlovoy SA, von Amsberg G, and Afiyatullov SS
- Subjects
- Alkaloids chemistry, Alkaloids isolation & purification, Cell Line, Tumor, Cytotoxins chemistry, Cytotoxins isolation & purification, Cytotoxins pharmacology, Diketopiperazines chemistry, Humans, Molecular Conformation, Molecular Structure, Spectrum Analysis, Diketopiperazines isolation & purification, Penicillium chemistry
- Abstract
Four new diketopiperazine alkaloids, citriperazines A-D were isolated from algae-derived Penicillium sp. KMM 4672. The structures of compounds 1-4 were determined using spectroscopic methods. The absolute configurations of compounds 1 and 4 were established by comparison of calculated and experimental ECD spectra. The cytotoxicity of compounds 1 - 4 against several human prostate cell lines was evaluated.
- Published
- 2020
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