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Salvia dumetorum essential oil (SDEO) was obtained using a Clevenger apparatus by hydrodistillation approach. The chemical composition of the essential oil was determined by GC-MS analysis. In this study SDEO was screened for its antibacterial activity against Staphylococcus aureus, Bacillus subtilis, Escherichia coli, and Candida albicans and the amount of biofilm formed by Streptococcus mutans bacteria. For the first time the chemical composition of SDEO growing in Central Kazakhstan was established. The results obtained from GC-MS showed the predominance of sesquiterpenoids (54.15%). The antibacterial study results showed that SDEO exhibited strong antibacterial activity against B. subtilis and S. aureus in vitro and also demonstrated an inhibitory effect on S. mutans biofilm formation on 1% sucrose medium. During the study, no antibacterial activity was detected against E. coli and C. albicans. These results demonstrated that SDEO can be used in the development of new antibacterial and anti-caries therapeutic dental products. [ABSTRACT FROM AUTHOR]

Prunus ulmifolia Franch. (Rosaceae) was investigated for its phytochemical composition from South-Eastern Kazakhstan for the first time. HPLC analysis confirmed rutin (0.88%) in ethanol extract, and the extract also exhibited antioxidant activity. The GC/MS analysis identified total 44 components from main groups e.g. oxygenated monoterpenes (51.06%), oxygenated sesquiterpenes (20.33%), non-terpene derivatives (18.71%), and sesquiterpene hydrocarbons (7.89%), and the maximum content was of acyclic alcoholic monoterpenoid citronellol (36.58%). The hierarchical cluster analysis (HCA) from previous reports and present study was used to demonstrate the variations between essential oil compositions in different Prunus species. It formed three main clusters, cluster I consisted of species with benzaldehyde as dominant component. Cluster II included plants with benzaldehyde as secondary component, and cluster III was of P. ulmifolia in which benzaldehyde was not detected. Further, the essential oil was assessed for cytotoxic and antimicrobial activities too, and it showed better cytotoxic but poor antimicrobial activities. [ABSTRACT FROM AUTHOR]

The aim of the study was to investigate volatile compounds from the aerial parts of Viola canina L. of the family Violaceae grown wild in Northern Kazakhstan for the first time. Viola canina is a common and widespread species of the temperate northern hemisphere. The oil from the aerial parts of V. canina, was obtained by hydrodistillation and investigated by gas chromatography combined with mass spectrometry. The main component of V. canina essential oil was phytol (55.2%). The obtained results showed differences in the composition of already studied Viola essential oils, such as essential oil of V. odorata L., V. etrusca Erben, V. tricolor L., V. arvensis Murr., V. tianshanica Maxim., V. serpens Wall. and V. hamiltoniana D. Don. There is a certain similarity with the composition of the essential oil of V. arvensis where phytol was also found as one of the main component (11.4%). [ABSTRACT FROM AUTHOR]