506 results
Search Results
2. Marine natural products.
- Author
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Carroll, Anthony R., Copp, Brent R., Grkovic, Tanja, Keyzers, Robert A., and Prinsep, Michεave;le R.
- Subjects
MARINE natural products ,MARINE phytoplankton ,MARINE microorganisms ,COUNTRY of origin (Immigrants) ,RED algae ,CNIDARIA - Abstract
Covering: January to the end of December 2022 This review covers the literature published in 2022 for marine natural products (MNPs), with 645 citations (633 for the period January to December 2022) referring to compounds isolated from marine microorganisms and phytoplankton, green, brown and red algae, sponges, cnidarians, bryozoans, molluscs, tunicates, echinoderms, the submerged parts of mangroves and other intertidal plants. The emphasis is on new compounds (1417 in 384 papers for 2022), together with the relevant biological activities, source organisms and country of origin. Pertinent reviews, biosynthetic studies, first syntheses, and syntheses that led to the revision of structures or stereochemistries, have been included. An analysis of NP structure class diversity in relation to biota source and biome is discussed. [ABSTRACT FROM AUTHOR]
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- 2024
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3. Hot off the Press.
- Author
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Hill, Robert A. and Sutherland, Andrew
- Subjects
BIOORGANIC chemistry ,NATURAL products ,ALSTONIA - Abstract
A personal selection of 32 recent papers is presented covering various aspects of current developments in bioorganic chemistry and novel natural products such as alscholarine A from Alstonia scholaris. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
4. A comprehensive classification of solvent systems used for natural product purifications in countercurrent and centrifugal partition chromatography.
- Author
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Skalicka-Woźniak, Krystyna and Garrard, Ian
- Subjects
SOLVENTS ,NATURAL products ,PARTITION chromatography ,SEPARATION (Technology) ,CHEMISTRY databases - Abstract
Covering: 1984 to end 2014 Using both library paper copies and modern electronic copies, every known, published, English-language journal paper that employs either countercurrent or centrifugal partition chromatography solvent systems for natural product purifications has been studied and the solvent systems classified in a comprehensive database. Papers were studied from the earliest found examples containing natural product separations in 1984 until the end of 2014. In total, 2594 solvent systems have been classified, of which 272 are gradient systems. To observe any trends or patterns in the data, the natural product solutes were divided into 21 classes and the solvent systems into 7 different types. The complete database, sorted according to natural product class, is available for download to assist separation scientists in future liquid–liquid chromatography purifications. [ABSTRACT FROM AUTHOR]
- Published
- 2015
- Full Text
- View/download PDF
5. Marine natural products.
- Author
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Carroll, Anthony R., Copp, Brent R., Davis, Rohan A., Keyzers, Robert A., and Prinsep, Michεave;le R.
- Subjects
MARINE natural products ,MARINE phytoplankton ,MARINE microorganisms ,COUNTRY of origin (Immigrants) ,RED algae ,CNIDARIA - Abstract
Covering: January to December 2021 This review covers the literature published in 2021 for marine natural products (MNPs), with 736 citations (724 for the period January to December 2021) referring to compounds isolated from marine microorganisms and phytoplankton, green, brown and red algae, sponges, cnidarians, bryozoans, molluscs, tunicates, echinoderms, mangroves and other intertidal plants and microorganisms. The emphasis is on new compounds (1425 in 416 papers for 2021), together with the relevant biological activities, source organisms and country of origin. Pertinent reviews, biosynthetic studies, first syntheses, and syntheses that led to the revision of structures or stereochemistries, have been included. An analysis of the number of authors, their affiliations, domestic and international collection locations, focus of MNP studies, citation metrics and journal choices is discussed. [ABSTRACT FROM AUTHOR]
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- 2023
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6. Hot off the press.
- Author
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Hill, Robert A. and Sutherland, Andrew
- Subjects
BIOORGANIC chemistry ,NATURAL products - Abstract
A personal selection of 32 recent papers is presented covering various aspects of current developments in bioorganic chemistry and novel natural products such as chlorfortunone A from Chloranthus fortunei. [ABSTRACT FROM AUTHOR]
- Published
- 2022
- Full Text
- View/download PDF
7. Marine natural products.
- Author
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Carroll, Anthony R., Copp, Brent R., Davis, Rohan A., Keyzers, Robert A., and Prinsep, Michεave;le R.
- Subjects
MARINE natural products ,MARINE phytoplankton ,MARINE microorganisms ,RED algae ,BROWN algae ,MARINE invertebrates - Abstract
Covering: 2020 This review covers the literature published in 2020 for marine natural products (MNPs), with 757 citations (747 for the period January to December 2020) referring to compounds isolated from marine microorganisms and phytoplankton, green, brown and red algae, sponges, cnidarians, bryozoans, molluscs, tunicates, echinoderms, mangroves and other intertidal plants and microorganisms. The emphasis is on new compounds (1407 in 420 papers for 2020), together with the relevant biological activities, source organisms and country of origin. Pertinent reviews, biosynthetic studies, first syntheses, and syntheses that led to the revision of structures or stereochemistries, have been included. A meta analysis of bioactivity data relating to new MNPs reported over the last five years is also presented. [ABSTRACT FROM AUTHOR]
- Published
- 2022
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8. Secondary metabolites from mangrove-associated fungi: source, chemistry and bioactivities.
- Author
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Chen, Senhua, Cai, Runlin, Liu, Zhaoming, Cui, Hui, and She, Zhigang
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MANGROVE plants ,METABOLITES ,MARINE fungi ,MANGROVE forests ,INTERTIDAL zonation ,FUNGI - Abstract
Covering 1989 to 2020 The mangrove forests are a complex ecosystem occurring at tropical and subtropical intertidal estuarine zones and nourish a diverse group of microorganisms including fungi, actinomycetes, bacteria, cyanobacteria, algae, and protozoa. Among the mangrove microbial community, mangrove associated fungi, as the second-largest ecological group of the marine fungi, not only play an essential role in creating and maintaining this biosphere but also represent a rich source of structurally unique and diverse bioactive secondary metabolites, attracting significant attention of organic chemists and pharmacologists. This review summarizes the discovery relating to the source and characteristics of metabolic products isolated from mangrove-associated fungi over the past thirty years (1989–2020). Its emphasis included 1387 new metabolites from 451 papers, focusing on bioactivity and the unique chemical diversity of these natural products. [ABSTRACT FROM AUTHOR]
- Published
- 2022
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9. Natural cholinesterase inhibitors from marine organisms.
- Author
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Moodie, Lindon W. K., Sepčić, Kristina, Turk, Tom, Frangeη, Robert, and Svenson, Johan
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CHOLINESTERASE inhibitors ,MARINE natural products ,MARINE organisms ,SCIENTIFIC literature ,NATURAL numbers ,CHOLINESTERASE reactivators - Abstract
Covering: Published between 1974 up to 2018 Inhibition of cholinesterases is a common approach for the management of several disease states. Most notably, cholinesterase inhibitors are used to alleviate the symptoms of neurological disorders like dementia and Alzheimer's disease and treat myasthenia gravis and glaucoma. Historically, most drugs of natural origin have been isolated from terrestrial sources and inhibitors of cholinesterases are no exception. However, the last 50 years have seen a rise in the quantity of marine natural products with close to 25 000 reported in the scientific literature. A number of marine natural products with potent cholinesterase inhibitory properties have also been reported; isolated from a variety of marine sources from algae to ascidians. Representing a diverse range of structural classes, these compounds provide inspirational leads that could aid the development of therapeutics. The current paper aims to, for the first time, comprehensively summarize the literature pertaining to cholinesterase inhibitors derived from marine sources, including the first papers published in 1974 up to 2018. The review does not report bioactive extracts, only isolated compounds, and a specific focus lies on compounds with reported dose–response data. In vivo and mechanistic data is included for compounds where this is reported. In total 185 marine cholinesterase inhibitors and selected analogs have been identified and reported and some of the compounds display inhibitory activities comparable or superior to cholinesterase inhibitors in clinical use. [ABSTRACT FROM AUTHOR]
- Published
- 2019
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10. Hot off the press.
- Author
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Hill, Robert A. and Sutherland, Andrew
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BIOORGANIC chemistry ,NATURAL products - Abstract
A personal selection of 32 recent papers is presented covering various aspects of current developments in bioorganic chemistry and novel natural products such as chlorahupetone A from Chloranthus henryi var. hupehensis. [ABSTRACT FROM AUTHOR]
- Published
- 2021
- Full Text
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11. Sesterterpenoids: chemistry, biology, and biosynthesis.
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Li, Keke and Gustafson, Kirk R.
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BIOSYNTHESIS ,CANCER cell growth ,FUNCTIONAL groups ,BIOLOGY ,SKELETON ,COVID-19 - Abstract
Covering: July 2012 to December 2019 Over the last seven years, expanding research efforts focused on sesterterpenoids has led to the isolation, identification, and characterization of numerous structurally novel and biologically active sesterterpenoids. These newly reported sesterterpenoids provide diverse structures that often incorporate unprecedented ring systems and new carbon skeletons, as well as unusual functional group arrays. Biological activities of potential biomedical importance including suppression of cancer cell growth, inhibition of enzymatic activity, and modulation of receptor signaling, as well as ecologically important functions such as antimicrobial effects and deterrence of herbivorous insects have been associated with a variety of sesterterpenoids. There has also been a rapid growth in our knowledge of the genomics, enzymology, and specific pathways associated with sesterterpene biosynthesis. This has opened up new opportunities for future sesterterpene discovery and diversification through the expression of new cryptic metabolites and the engineered manipulation of associated biosynthetic machinery and processes. In this paper we reviewed 498 new sesterterpenoids, including their structures, source organisms, country of origin, relevant bioactivities, and biosynthesis. [ABSTRACT FROM AUTHOR]
- Published
- 2021
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12. Biosynthesis and heterologous production of furanocoumarins: perspectives and current challenges.
- Author
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Rodrigues, Joana L. and Rodrigues, Lígia R.
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PLANT metabolites ,METABOLITES ,AMINO acids ,BIOSYNTHESIS ,PLANT extracts ,COUMARINS - Abstract
Covering: up to October 2020 Furanocoumarins are plant secondary metabolites used to treat several skin disorders, such as psoriasis and vitiligo, and also with other potential therapeutic activities. Furanocoumarins are extracted from plants where they accumulate in low amounts over long growth periods. In addition, their extraction and purification are difficult in an environmentally unfriendly and expensive process. Hence, new sustainable and greener production schemes able to overcome such limitations ought to be developed. While the heterologous production of simple coumarins has been demonstrated, the biosynthesis of more complex furanocoumarins remains greatly unexplored. Although several important steps of the pathway have been elucidated in the last decade, the complete pathway has not been completely unravelled. In this paper, we review the natural conversion of amino acids into furanocoumarins, as well as the heterologous expression of each enzyme of the pathway. We also explore the challenges that need to be addressed so that their heterologous production can become a viable alternative. [ABSTRACT FROM AUTHOR]
- Published
- 2021
- Full Text
- View/download PDF
13. Marine natural products.
- Author
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Carroll, Anthony R., Copp, Brent R., Davis, Rohan A., Keyzers, Robert A., and Prinsep, Michεave;le R.
- Subjects
MARINE natural products ,MARINE phytoplankton ,MANGROVE plants ,MARINE microorganisms ,RED algae ,MARINE fungi ,CNIDARIA - Abstract
This review covers the literature published in 2019 for marine natural products (MNPs), with 719 citations (701 for the period January to December 2019) referring to compounds isolated from marine microorganisms and phytoplankton, green, brown and red algae, sponges, cnidarians, bryozoans, molluscs, tunicates, echinoderms, mangroves and other intertidal plants and microorganisms. The emphasis is on new compounds (1490 in 440 papers for 2019), together with the relevant biological activities, source organisms and country of origin. Pertinent reviews, biosynthetic studies, first syntheses, and syntheses that led to the revision of structures or stereochemistries, have been included. Methods used to study marine fungi and their chemical diversity have also been discussed. [ABSTRACT FROM AUTHOR]
- Published
- 2021
- Full Text
- View/download PDF
14. Hot off the Press.
- Author
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Hill, Robert A. and Sutherland, Andrew
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BIOORGANIC chemistry ,NATURAL products ,HYPERICUM - Abstract
A personal selection of 32 recent papers is presented covering various aspects of current developments in bioorganic chemistry and novel natural products such as longisglucinol A from Hypericum longistylum. [ABSTRACT FROM AUTHOR]
- Published
- 2020
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15. Marine natural products.
- Author
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Carroll, Anthony R., Copp, Brent R., Davis, Rohan A., Keyzers, Robert A., and Prinsep, Michεave;le R.
- Subjects
MARINE natural products ,MARINE phytoplankton ,MARINE microorganisms ,MARINE invertebrates ,BROWN algae ,RED algae - Abstract
This review covers the literature published between January and December in 2018 for marine natural products (MNPs), with 717 citations (706 for the period January to December 2018) referring to compounds isolated from marine microorganisms and phytoplankton, green, brown and red algae, sponges, cnidarians, bryozoans, molluscs, tunicates, echinoderms, mangroves and other intertidal plants and microorganisms. The emphasis is on new compounds (1554 in 469 papers for 2018), together with the relevant biological activities, source organisms and country of origin. Reviews, biosynthetic studies, first syntheses, and syntheses that led to the revision of structures or stereochemistries, have been included. The proportion of MNPs assigned absolute configuration over the last decade is also surveyed. [ABSTRACT FROM AUTHOR]
- Published
- 2020
- Full Text
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16. Hot off the Press.
- Author
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Hill, Robert A. and Sutherland, Andrew
- Subjects
BIOORGANIC chemistry ,NATURAL products ,CHEMISTRY ,COUNTERCURRENT chromatography - Abstract
A personal selection of 32 recent papers is presented covering various aspects of current developments in bioorganic chemistry and novel natural products such as burlemarxione A from Clusia burle-marxii. [ABSTRACT FROM AUTHOR]
- Published
- 2019
- Full Text
- View/download PDF
17. Dibenzofurans and derivatives from lichens and ascomycetes.
- Author
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Millot, Marion, Dieu, Amandine, and Tomasi, Sophie
- Subjects
DIBENZOFURANS ,LICHENS ,ASCOMYCETES ,METABOLITES ,MYXOMYCETES - Abstract
Covering: up to 2016. When looking for dibenzofuran in the biochemical databases, most papers and reviews deal with pollutants and polychlorinated dibenzofurans like dioxins. But dibenzofurans are also biosynthetized by a wide diversity of organisms in nature. Even if dibenzofurans from natural sources represent a small class of secondary metabolites, compared to flavonoids, xanthones or terpenoids, they are often endowed with interesting biological properties which have been recently described. This review provides an update on papers describing dibenzofurans from lichens, ascomycetes and cultured mycobionts. Other sources, such as basidiomycetes, myxomycetes or plants produce sporadically interesting dibenzofurans in terms of structures and activities. [ABSTRACT FROM AUTHOR]
- Published
- 2016
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18. Phytochemical and pharmacological properties of the genus Alpinia from 2016 to 2023.
- Author
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Isoo Youn, Ah-Reum Han, Donglan Piao, Hwaryeong Lee, Hyunkyung Kwak, Yeju Lee, Joo-Won Nam, and Eun Kyoung Seo
- Subjects
ALPINIA ,ANGIOSPERMS ,CULTIVATED plants ,ZINGIBERACEAE ,TRADITIONAL medicine - Abstract
Alpinia is the largest genus of flowering plants in the ginger family, Zingiberaceae, and comprises about 500 species. Many Alpinia are commonly cultivated ornamental plants, and some are used as spices or traditional medicine to treat inflammation, hyperlipidemia, and cancers. However, only a few comprehensive reviews have been published on the phytochemistry and pharmacology of this genus, and the latest review was published in 2017. In this review, we provide an extensive coverage of the studies on Alpinia species reported from 2016 through 2023, including newly isolated compounds and potential biological effects. The present review article shows that Alpinia species have a wide spectrum of pharmacological activities, most due to the activities of diarylheptanoids, terpenoids, flavonoids, and phenolics. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
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19. Biosynthesis, biological activities, and structure-activity relationships of decalin-containing tetramic acid derivatives isolated from fungi.
- Author
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Hyun Woo Kim, Jin Woo Lee, and Sang Hee Shim
- Subjects
TETRAMIC acids ,ACID derivatives ,STRUCTURE-activity relationships ,FUNGAL metabolites ,BACTERIAL genes - Abstract
Decalin-containing tetramic acid derivatives, especially 3-decalinoyltetramic acids (3-DTAs), are commonly found as fungal secondary metabolites. Numerous biological activities of this class of compounds, such as antibiotic, antiviral, antifungal, antiplasmodial, and antiprotozoal properties, have been the subject of ongoing research. For this reason, these molecules have attracted a lot of interest from the scientific community and various efforts including semi-synthesis, co-culturing with bacteria and biosynthetic gene sequencing have been made to obtain more derivatives. In this review, 3-DTAs are classified into four major groups based on the absolute configuration of the bicyclic decalin ring. Their biosynthetic pathways, various biological activities, and structure-activity relationship are then introduced. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
20. Medium-sized peptides from microbial sources with potential for antibacterial drug development.
- Author
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Jianwei Chen, Wei Wang, Xubin Hu, Yujie Yue, Xingyue Lu, Chenjie Wang, Bin Wei, Huawei Zhang, and Hong Wang
- Subjects
CHEMICAL stability ,DRUG discovery ,ANTIMICROBIAL peptides ,PROTEIN conformation ,STRUCTURE-activity relationships - Abstract
As the rapid development of antibiotic resistance shrinks the number of clinically available antibiotics, there is an urgent need for novel options to fill the existing antibiotic pipeline. In recent years, antimicrobial peptides have attracted increased interest due to their impressive broad-spectrum antimicrobial activity and low probability of antibiotic resistance. However, macromolecular antimicrobial peptides of plant and animal origin face obstacles in antibiotic development because of their extremely short elimination half-life and poor chemical stability. Herein, we focus on medium-sized antibacterial peptides (MAPs) of microbial origin with molecular weights below 2000 Da. The low molecular weight is not sufficient to form complex protein conformations and is also associated to a better chemical stability and easier modifications. Microbially-produced peptides are often composed of a variety of non-protein amino acids and terminal modifications, which contribute to improving the elimination half-life of compounds. Therefore, MAPs have great potential for drug discovery and are likely to become key players in the development of next-generation antibiotics. In this review, we provide a detailed exploration of the modes of action demonstrated by 45 MAPs and offer a concise summary of the structure-activity relationships observed in these MAPs. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
21. Marine natural products.
- Author
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Carroll, Anthony R., Copp, Brent R., Davis, Rohan A., Keyzers, Robert A., and Prinsep, Michèle R.
- Subjects
MARINE natural products ,MARINE microorganisms ,ECHINODERMATA ,RED algae ,STEREOCHEMISTRY ,ALGAE-cnidarian relationships - Abstract
Covering: January to December 2017 This review covers the literature published in 2017 for marine natural products (MNPs), with 740 citations (723 for the period January to December 2017) referring to compounds isolated from marine microorganisms and phytoplankton, green, brown and red algae, sponges, cnidarians, bryozoans, molluscs, tunicates, echinoderms, mangroves and other intertidal plants and microorganisms. The emphasis is on new compounds (1490 in 477 papers for 2017), together with the relevant biological activities, source organisms and country of origin. Reviews, biosynthetic studies, first syntheses, and syntheses that led to the revision of structures or stereochemistries, have been included. Geographic distributions of MNPs at a phylogenetic level are reported. [ABSTRACT FROM AUTHOR]
- Published
- 2019
- Full Text
- View/download PDF
22. Hot off the press.
- Author
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Hill, Robert A. and Sutherland, Andrew
- Subjects
NATURAL products ,X-ray imaging ,TERPENES ,GLYCOSIDES ,LACTONES - Abstract
A personal selection of 32 recent papers is presented covering various aspects of current developments in bioorganic chemistry and novel natural products such as kadsuraol A from Kadsura longipedunculata. [ABSTRACT FROM AUTHOR]
- Published
- 2018
- Full Text
- View/download PDF
23. Marine natural products.
- Author
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Blunt, John W., Carroll, Anthony R., Copp, Brent R., Davis, Rohan A., Keyzers, Robert A., and Prinsep, Michèle R.
- Subjects
MARINE natural products ,PHYTOPLANKTON ,RED algae ,MOLECULAR structure ,STEREOCHEMISTRY - Abstract
Covering: 2016. Previous review: Nat. Prod. Rep., 2017, 34, 235–294 This review covers the literature published in 2016 for marine natural products (MNPs), with 757 citations (643 for the period January to December 2016) referring to compounds isolated from marine microorganisms and phytoplankton, green, brown and red algae, sponges, cnidarians, bryozoans, molluscs, tunicates, echinoderms, mangroves and other intertidal plants and microorganisms. The emphasis is on new compounds (1277 in 432 papers for 2016), together with the relevant biological activities, source organisms and country of origin. Reviews, biosynthetic studies, first syntheses, and syntheses that led to the revision of structures or stereochemistries, have been included. [ABSTRACT FROM AUTHOR]
- Published
- 2018
- Full Text
- View/download PDF
24. Hot off the press.
- Author
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Hill, Robert A. and Sutherland, Andrew
- Subjects
BIOORGANIC chemistry ,CHEMICAL biology ,NATURAL products ,STREPTOMYCES ,BIOSYNTHESIS - Abstract
A personal selection of 32 recent papers is presented covering various aspects of current developments in bioorganic chemistry and novel natural products such as tryptorubin A isolated from a Streptomyces species. [ABSTRACT FROM AUTHOR]
- Published
- 2017
- Full Text
- View/download PDF
25. The insect microbiome is a vast source of bioactive small molecules.
- Author
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Grundmann, Carlismari Oliveira, Guzman, Juan, Vilcinskas, Andreas, and Pupo, Mônica Tallarico
- Subjects
SMALL molecules ,MICROBIAL metabolites ,BIOACTIVE compounds ,INSECTS ,PROTEOBACTERIA ,METABOLITES ,NATURAL products - Abstract
Covering: September 1964 to June 2023 Bacteria and fungi living in symbiosis with insects have been studied over the last sixty years and found to be important sources of bioactive natural products. Not only classic producers of secondary metabolites such as Streptomyces and other members of the phylum Actinobacteria but also numerous bacteria from the phyla Proteobacteria and Firmicutes and an impressive array of fungi (usually pathogenic) serve as the source of a structurally diverse number of small molecules with important biological activities including antimicrobial, cytotoxic, antiparasitic and specific enzyme inhibitors. The insect niche is often the exclusive provider of microbes producing unique types of biologically active compounds such as gerumycins, pederin, dinactin, and formicamycins. However, numerous insects still have not been described taxonomically, and in most cases, the study of their microbiota is completely unexplored. In this review, we present a comprehensive survey of 553 natural products produced by microorganisms isolated from insects by collating and classifying all the data according to the type of compound (rather than the insect or microbial source). The analysis of the correlations among the metadata related to insects, microbial partners, and their produced compounds provides valuable insights into the intricate dynamics between insects and their symbionts as well as the impact of their metabolites on these relationships. Herein, we focus on the chemical structure, biosynthesis, and biological activities of the most relevant compounds. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
26. Bacterial cyclophane-containing RiPPs from radical SAM enzymes.
- Author
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Phan, Chin-Soon and Morinaka, Brandon I.
- Subjects
RADICALS (Chemistry) ,DRUG discovery ,ENZYMES ,PEPTIDES ,NATURAL products - Abstract
Covering: 2016 to 2023 Ribosomally synthesized and posttranslationally modified peptides (RiPPs) continue to be a rich source of chemically diverse and bioactive peptide natural products. In recent years, cyclophane-containing RiPP natural products and their biosynthetic pathways have been more frequently encountered. This highlight will focus on bacterial monoaryl cyclophane-containing RiPPs. This class of RiPPs is produced by radical SAM/SPASM enzymes that form a crosslink between the aromatic ring and sidechain of two amino acid residues of the precursor peptide. Selected natural products from these pathways exhibit specific antibacterial activity against gram-negative pathogens. The approaches used to discover these pathways and products will be described and categorized as natural product-first or enzyme-first. The breadth of ring systems formed by the enzymes, enzyme mechanism, and recent reports of synthetic methods for constructing these ring systems will also be presented. Bacterial cyclophane-containing RiPPs and their biosynthetic enzymes represent an untapped source of scaffolds for drug discovery and tools for synthetic biology. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
27. Marine natural products.
- Author
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Blunt, John W., Copp, Brent R., Keyzers, Robert A., Munro, Murray H. G., and Prinsep, Michèle R.
- Subjects
MARINE natural products ,MARINE microorganisms ,PHYTOPLANKTON ,CNIDARIA ,BIOSYNTHESIS ,STEREOCHEMISTRY - Abstract
Covering: 2015. Previous review: Nat. Prod. Rep., 2016, 33, 382–431 This review covers the literature published in 2015 for marine natural products (MNPs), with 1220 citations (792 for the period January to December 2015) referring to compounds isolated from marine microorganisms and phytoplankton, green, brown and red algae, sponges, cnidarians, bryozoans, molluscs, tunicates, echinoderms, mangroves and other intertidal plants and microorganisms. The emphasis is on new compounds (1340 in 429 papers for 2015), together with the relevant biological activities, source organisms and country of origin. Reviews, biosynthetic studies, first syntheses, and syntheses that lead to the revision of structures or stereochemistries, have been included. [ABSTRACT FROM AUTHOR]
- Published
- 2017
- Full Text
- View/download PDF
28. Hot off the press.
- Author
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Hill, Robert A. and Sutherland, Andrew
- Subjects
BIOORGANIC chemistry ,CYANOBACTERIA ,MARINE natural products ,CLUB mosses ,CHEMICAL structure - Abstract
A personal selection of 32 recent papers is presented covering various aspects of current developments in bioorganic chemistry and novel natural products such as kanamienamide from the marine cyanobacterium Moorea bouillonii. [ABSTRACT FROM AUTHOR]
- Published
- 2016
- Full Text
- View/download PDF
29. Contents list.
- Subjects
NATURAL products ,ORGANOLITHIUM compounds ,ESTERS ,COUPLING reactions (Chemistry) ,ADVISORY boards ,EDITORIAL boards - Abstract
The article discusses the periodical's “Natural Product Paper" contents list on topics including tertiary organolithium reagents and ester coupling reactions and mentions board members including editor Richard Kelly, advisory board member Mike Beale and editorial board member Daniel Romo.
- Published
- 2015
- Full Text
- View/download PDF
30. The pearl jubilee of microcin J25: thirty years of research on an exceptional lasso peptide.
- Author
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Baquero, Fernando, Beis, Konstantinos, Craik, David J., Li, Yanyan, Link, A. James, Rebuffat, Sylvie, Salomón, Raúl, Severinov, Konstantin, Zirah, Séverine, and Hegemann, Julian D.
- Subjects
PEPTIDES ,RNA polymerases ,GENE clusters ,NATURAL products ,GRAM-negative bacteria ,PEPTIDE antibiotics ,BIOENGINEERING - Abstract
Covering: 1992 up to 2023 Since their discovery, lasso peptides went from peculiarities to be recognized as a major family of ribosomally synthesized and post-translationally modified peptide (RiPP) natural products that were shown to be spread throughout the bacterial kingdom. Microcin J25 was first described in 1992, making it one of the earliest known lasso peptides. No other lasso peptide has since then been studied to such an extent as microcin J25, yet, previous review articles merely skimmed over all the research done on this exceptional lasso peptide. Therefore, to commemorate the 30th anniversary of its first report, we give a comprehensive overview of all literature related to microcin J25. This review article spans the early work towards the discovery of microcin J25, its biosynthetic gene cluster, and the elucidation of its three-dimensional, threaded lasso structure. Furthermore, the current knowledge about the biosynthesis of microcin J25 and lasso peptides in general is summarized and a detailed overview is given on the biological activities associated with microcin J25, including means of self-immunity, uptake into target bacteria, inhibition of the Gram-negative RNA polymerase, and the effects of microcin J25 on mitochondria. The in vitro and in vivo models used to study the potential utility of microcin J25 in a (veterinary) medicine context are discussed and the efforts that went into employing the microcin J25 scaffold in bioengineering contexts are summed up. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
31. The incredible story of ophiobolin A and sphaeropsidin A: two fungal terpenes from wilt-inducing phytotoxins to promising anticancer compounds.
- Author
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Evidente, Antonio
- Subjects
PHYTOTOXINS ,TERPENES ,CANKER (Plant disease) ,STRUCTURE-activity relationships ,ANTINEOPLASTIC agents ,HOST plants ,SALVINORIN A - Abstract
Covering: 2000 to 2023 This review presents the exceptional story of ophiobolin A (OphA) and sphaeropsidin A (SphA), a sesterterpene and a diterpene, respectively, which were initially isolated as fungal phytotoxins and subsequently shown to possess other interesting biological activities, including promising anticancer activities. Ophiobolin A is a phytotoxin produced by different fungal pathogens, all belonging to the Bipolaris genus. Initially, it was only known as a very dangerous phytotoxin produced by fungi attacking essential cereals, such as rice and barley. However, extensive and interesting studies were carried out to define its original carbon skeleton, which is characterized by a typical 5 : 8 : 5 ring system and shared with fusicoccins and cotylenins, and its phytotoxic activity on host and non-host plants. The biosynthesis of OphA was also defined by describing the different steps starting from mevalonate and through the rearrangement of the acyclic C-25 precursor lead the toxin is obtained. OphA was also produced as a bioherbicide from Drechslera gigantea and proposed for the biocontrol of the widespread and dangerous weed Digitaria sanguinaria. To date, more than sixty ophiobolins have been isolated from different fungi and their biological activities and structure–activity relationship investigated, which were also described using their hemisynthetic derivatives. In the last two decades, thorough studies have been performed on the potential anticancer activity of OphA and its original mode of action, attracting great interest from scientists. Sphaeropsidin A has a similar story. It was isolated as the main phytotoxin from Diplodia cupressi, the causal agent of Italian cypress canker disease, resulting in the loss of millions of plants in a few years in the Mediterranean basin. The damage to the forest, environment and ornamental heritage are noteworthy and economic losses are also suffered by tree nurseries and the wood industry. Six natural analogues of SphA were isolated and several interesting hemisynthetic derivatives were prepared to study its structure–activity relationship. Surprisingly, sphaeropsidin A showed other interesting biological activities, including antibiotic, antifungal, and antiviral. In the last decade, extensive studies have focused on the anticancer activity and original mode of action of SphA. Furthermore, specific hemisynthetic studies enable the preparation of derivatives of SphA, preserving its chromophore, which showed a noteworthy increase in anticancer activity. It has been demonstrated that ophiobolin A and sphaeropsidin A are promising natural products showing potent activity against some malignant cancers, such as brain glioblastoma and different melanomas. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
32. Class II terpene cyclases: structures, mechanisms, and engineering.
- Author
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Pan, Xingming, Rudolf, Jeffrey D., and Dong, Liao-Bin
- Subjects
CYCLASES ,TERPENES ,STRUCTURAL engineering ,NATURAL products ,ENGINEERING ,GIBBERELLINS ,DITERPENES - Abstract
Covering: up to July 2023 Terpene cyclases (TCs) catalyze some of the most complicated reactions in nature and are responsible for creating the skeletons of more than 95 000 terpenoid natural products. The canonical TCs are divided into two classes according to their structures, functions, and mechanisms. The class II TCs mediate acid–base-initiated cyclization reactions of isoprenoid diphosphates, terpenes without diphosphates (e.g., squalene or oxidosqualene), and prenyl moieties on meroterpenes. The past twenty years witnessed the emergence of many class II TCs, their reactions and their roles in biosynthesis. Class II TCs often act as one of the first steps in the biosynthesis of biologically active natural products including the gibberellin family of phytohormones and fungal meroterpenoids. Due to their mechanisms and biocatalytic potential, TCs elicit fervent attention in the biosynthetic and organic communities and provide great enthusiasm for enzyme engineering to construct novel and bioactive molecules. To engineer and expand the structural diversities of terpenoids, it is imperative to fully understand how these enzymes generate, precisely control, and quench the reactive carbocation intermediates. In this review, we summarize class II TCs from nature, including sesquiterpene, diterpene, triterpene, and meroterpenoid cyclases as well as noncanonical class II TCs and inspect their sequences, structures, mechanisms, and structure-guided engineering studies. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
33. Discovery, synthesis, activities, structure–activity relationships, and clinical development of combretastatins and analogs as anticancer drugs. A comprehensive review.
- Author
-
Singh, Sheo B.
- Subjects
STRUCTURE-activity relationships ,ANTINEOPLASTIC agents ,PRODRUGS ,ANAPLASTIC thyroid cancer ,ANTIMITOTIC agents ,PHARMACEUTICAL chemistry - Abstract
Covering: 1982 to up to the end of 2022 Bioassay guided purification of the extracts of Combretum caffrum led to the discovery of six series of combretastatins A–D with cytotoxic activities ranging from sub nM to >50 μM ED
50 's against a wide variety of cancer cell lines. Of these, cis-stilbenes combretastatins A-4 and A-1 were the most potent, exhibiting in vivo efficacy against a wide variety of tumor types in murine models. These antimitotic agents inhibited tubulin polymerization by reversibly binding to the colchicine binding sites. They inhibited tumor growth by a novel antivascular and antineogenesis mechanism in which they stopped blood flows to the blood vessels causing necrosis. Over 20 clinical trials of the phosphate prodrugs of combretastatin A-4 (CA4P) and A-1 (CA1P) showed objective and stable responses against many tumor types, with increased survival times of many patients along with the confirmed cure of certain patients inflicted with anaplastic thyroid cancers. Medicinal chemistry efforts led to the identification of three new leads (AVE8062, BNC105P, SCB01A) with improved in vitro and in vivo potency and an often-improved cellular spectrum. Unfortunately, these preclinical improvements did not translate clinically in any meaningful way. Objectively, CA4P remained the best compound and has garnered many Orphan drug designations by FDA. Clinical trials with tumor genetic mapping, particularly from previous responders, may help boost the success of these compounds in future studies. A comprehensive review of combretastatin series A–D, including bioassay guided discovery, total syntheses, and structure–activity relationship (SAR) studies, biological and mechanistic studies, and preclinical and clinical evaluations of the isolated combretastatins and analogs, along with the personal perspective of the author who originated this project, is presented. [ABSTRACT FROM AUTHOR]- Published
- 2024
- Full Text
- View/download PDF
34. Recent advances in oxidative phenol coupling for the total synthesis of natural products.
- Author
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Carson, Matthew C. and Kozlowski, Marisa C.
- Subjects
OXIDATIVE coupling ,NATURAL products ,PHENOL ,PHENOLS ,INDOLE compounds - Abstract
Covering: 2008 to 2023 This review will describe oxidative phenol coupling as applied in the total synthesis of natural products. This review covers catalytic and electrochemical methods with a brief comparison to stoichiometric and enzymatic systems assessing their practicality, atom economy, and other measures. Natural products forged by C–C and C–O oxidative phenol couplings as well as from alkenyl phenol couplings will be addressed. Additionally, exploration into catalytic oxidative coupling of phenols and other related species (carbazoles, indoles, aryl ethers, etc.) will be surveyed. Future directions of this particular area of research will also be assessed. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
35. Natural ten-membered lactones: sources, structural diversity, biological activity, and intriguing future.
- Author
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Dubovik, Vsevolod, Dalinova, Anna, and Berestetskiy, Alexander
- Subjects
POLYKETIDES ,LACTONES ,SCIENTIFIC discoveries ,NATURAL products ,MARINE organisms - Abstract
Covering: 2012 to 2022 Ten-membered lactones (TMLs) are an interesting and diverse group of natural polyketides that are abundant in fungi and, to a lesser extent, in bacteria, marine organisms, and insects. TMLs are known for their ability to exhibit a wide spectrum of biological activity, including phytotoxic, cytotoxic, antifungal, antibacterial, and others. However, the random discovery of these compounds by scientific groups with various interests worldwide has resulted in patchy information about their distribution among different organisms and their biological activity. Therefore, despite more than 60 years of research history, there is still no common understanding of the natural sources of TMLs, their structural type classification, and most characteristic biological activities. The controversial nomenclature, incorrect or erroneous structure elucidation, poor identification of producing organisms, and scattered information on the biological activity of compounds – all these factors have led to the problems with dereplication and the directed search for TMLs. This review consists of two parts: the first part (Section 2) covers 104 natural TMLs, published between 2012 and 2022 (after the publishing of the previous review), and the second part (Section 3) summarizes information about 214 TMLs described during 1964–2022 and as a result highlights the main problems and trends in the study of these intriguing natural products. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
36. Synthesis and mode of action of oligomeric sesquiterpene lactones.
- Author
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Li, Chao, Jones, Alexander X., and Lei, Xiaoguang
- Subjects
ORGANIC synthesis ,LACTONES ,SESQUITERPENES ,CHEMICAL synthesis ,BIOMIMETIC synthesis ,LIGATION reactions ,AFFINITY chromatography - Abstract
Covering: up to 2015 In this highlight we describe two case studies from our laboratory, involving the biomimetic syntheses and the biological mechanism elucidation of the bioactive oligomeric sesquiterpenoids, (+)-ainsliadimer A (4) and (−)-ainsliatrimer A (5). Ainsliadimer A possesses potent anti-inflammatory activity by inhibition of the NF-κB signalling pathway via binding at a previously untargeted allosteric site. (−)-Ainsliatrimer A induces apoptosis in cancer cells by activation of PPARγ. Furthermore, we highlight a new bioorthogonal ligation (TQ-ligation) developed in our laboratory which facilitates the target identification of complex natural products via pre-target fluorescence imaging and affinity chromatography. Generally, this paper will discuss the complete process from total synthesis to biological studies of complex natural products, and from the establishment of new bio-orthogonal chemistry to successful target identification. Our approach provides a systematic and efficient methodology for addressing the challenge of natural product target identification. [ABSTRACT FROM AUTHOR]
- Published
- 2016
- Full Text
- View/download PDF
37. Marine natural products.
- Author
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Blunt, John W., Copp, Brent R., Keyzers, Robert A., Munro, Murray H. G., and Prinsep, Michèle R.
- Subjects
MARINE natural products ,MARINE microorganisms ,PHYTOPLANKTON ,BROWN algae ,RED algae ,SPONGES (Invertebrates) - Abstract
Covering: 2014. Previous review: Nat. Prod. Rep., 2015, 32, 116–211 This review covers the literature published in 2014 for marine natural products (MNPs), with 1116 citations (753 for the period January to December 2014) referring to compounds isolated from marine microorganisms and phytoplankton, green, brown and red algae, sponges, cnidarians, bryozoans, molluscs, tunicates, echinoderms, mangroves and other intertidal plants and microorganisms. The emphasis is on new compounds (1378 in 456 papers for 2014), together with the relevant biological activities, source organisms and country of origin. Reviews, biosynthetic studies, first syntheses, and syntheses that lead to the revision of structures or stereochemistries, have been included. [ABSTRACT FROM AUTHOR]
- Published
- 2016
- Full Text
- View/download PDF
38. Hot off the press.
- Author
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Hill, Robert A. and Sutherland, Andrew
- Subjects
NATURAL products ,SALVIA ,BIOORGANIC chemistry ,DIELS-Alder reaction ,DRUG development - Abstract
A personal selection of 32 recent papers is presented covering various aspects of current developments in bioorganic chemistry and novel natural products such as salviaprione from Salvia prionitis. [ABSTRACT FROM AUTHOR]
- Published
- 2015
- Full Text
- View/download PDF
39. Natural products with therapeutic potential in melanoma metastasis.
- Author
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AlQathama, A. and Prieto, J. M.
- Subjects
MELANOMA treatment ,METASTASIS ,NATURAL products ,CANCER treatment ,SKIN cancer ,QUERCETIN ,SULFORAPHANE ,DACARBAZINE ,THERAPEUTICS - Abstract
Covering: up to 2014 Malignant melanoma is the most aggressive form of skin cancer and accounts for about 3% of all cases of malignant tumour. Its incidence is increasing worldwide and it is becoming resistant to current therapeutic agents. Natural products continue to provide lead cytotoxic compounds for cancer treatment but less attention has been given to antimigratory compounds. This paper systematically and critically surveys all natural products with direct in vitro and in vivo pharmacological effects on migration and/or metastasis of melanoma cells and maps the mechanisms of action for these underexploited properties. As a result, over 30 natural active principles are described acting mainly through their antagonistic effects upon the TNF-α and EP2 receptors or the suppression of several protein kinases involved in metastatic pathways such as RAS, PI3K, ERK and FAK. Also, some were able to reduce the level of mesenchymal biomarkers such as N-cadherin and/or elevate the expression of other molecules such as E-cadherin. Consequently, downstream transcription factors namely NF-kB, AP-1, ATF-2, CREB, and HIF were inactivated leading to diminished production of MMPs, IL-1, IL-6, COX-2, VEGF and GM-CSF. This review also discusses the opportunity of combination therapies based on natural products and approved drugs, such as the combination of EGCG and dacarbazine, or the combination of two natural compounds such as quercetin and sulforaphane. [ABSTRACT FROM AUTHOR]
- Published
- 2015
- Full Text
- View/download PDF
40. The use of the lactone motif in chemical communication.
- Author
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Schulz, Stefan and Hötling, Susann
- Subjects
BIOSYNTHESIS ,CHEMICAL symbiosis ,CHEMICAL synthesis ,CHEMICAL reactions ,COMMUNICATION strategies ,LACTONE derivatives ,LACTONES ,ORGANIC synthesis - Abstract
Covering: up to 2014 A wide variety of organisms communicate via the chemical channel using small molecules. A structural feature quite often found is the lactone motif. In the present paper, the current knowledge on such lactones will be described, concentrating on the structure, chemistry, function, biosynthesis and synthesis of these compounds. Lactone semiochemicals from insects, vertebrates and bacteria, which this article will focus on, are particularly well investigated. In addition, some ideas on the advantageous use of lactones as volatile signals, which promoted their evolutionary development, will be discussed. [ABSTRACT FROM AUTHOR]
- Published
- 2015
- Full Text
- View/download PDF
41. Hot off the press.
- Author
-
Hill, Robert A. and Sutherland, Andrew
- Subjects
BIOORGANIC chemistry ,NATURAL products ,SPECIES ,BIOCHEMISTRY ,ORGANIC chemistry - Abstract
A personal selection of 32 recent papers is presented covering various aspects of current developments in bioorganic chemistry and novel natural products such as sinulariaoid A from a Sinularia species. [ABSTRACT FROM AUTHOR]
- Published
- 2014
- Full Text
- View/download PDF
42. Unusual cyclic terpenoids with terminal pendant prenyl moieties: from occurrence to synthesis.
- Author
-
Kulcitki, Veaceslav, Harghel, Petru, and Ungur, Nicon
- Subjects
TERPENES ,CHEMICAL bonds ,PRENYLAMINE ,ELECTROPHILES ,CHEMICAL precursors - Abstract
Covering: 1966 up to the end of 2013 The paper reviews the known examples of cyclic terpenoids produced from open chain polyenic precursors by an “unusual” biosynthetic pathway, involving selective electrophilic attack on an internal double bond followed by cyclization. The resulting compounds possess cyclic backbones with pendant terminal prenyl groups. Synthetic approaches applied for the synthesis of such specifically functionalized compounds are also discussed, as well as biological activity of reported representatives. [ABSTRACT FROM AUTHOR]
- Published
- 2014
- Full Text
- View/download PDF
43. Chemistry, biosynthesis and biology of floral volatiles: roles in pollination and other functions.
- Author
-
Dötterl, Stefan and Gershenzon, Jonathan
- Subjects
POLLINATION ,EVIDENCE gaps ,BIOSYNTHESIS ,BIOLOGY ,POLLINATORS - Abstract
Covering: 2010 to 2023 Floral volatiles are a chemically diverse group of plant metabolites that serve multiple functions. Their composition is shaped by environmental, ecological and evolutionary factors. This review will summarize recent advances in floral scent research from chemical, molecular and ecological perspectives. It will focus on the major chemical classes of floral volatiles, on notable new structures, and on recent discoveries regarding the biosynthesis and the regulation of volatile emission. Special attention will be devoted to the various functions of floral volatiles, not only as attractants for different types of pollinators, but also as defenses of flowers against enemies. We will also summarize recent findings on how floral volatiles are affected by abiotic stressors, such as increased temperatures and drought, and by other organisms, such as herbivores and flower-dwelling microbes. Finally, this review will indicate current research gaps, such as the very limited knowledge of the isomeric pattern of chiral compounds and its importance in interspecific interactions. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
44. Natural products with 1,2-oxazine scaffold: occurrence, chemical diversity, bioactivity, synthesis, and biosynthesis.
- Author
-
Yan, Li-Hong, Li, Xin, and Wang, Bin-Gui
- Subjects
NATURAL products ,OXAZINES ,BIOSYNTHESIS ,ORGANIC synthesis ,CHEMICAL synthesis ,RESEARCH personnel - Abstract
Covering: up to the end of July, 2023 1,2-Oxazine is a heterocyclic scaffold rarely found in natural products and is characterized by a directly connected N–O bond in a six-membered ring. Since the discovery of geneserine, the first 1,2-oxazine-containing natural product (1,2-oxazine NP) being isolated from Calabar bean (Physostigma venenosum) in 1925, a total of 76 naturally occurring 1,2-oxazine NPs have been isolated and identified from various sources, which have attracted the attention of researchers in the field of natural product chemistry, organic synthesis, biosynthesis, and pharmacology. This review summarizes the chemical family of 1,2-oxazine NPs, focusing on their source organisms, structural diversities, chemical synthesis, and biosynthesis. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
45. Marine indole alkaloid diversity and bioactivity. What do we know and what are we missing?
- Author
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Holland, Darren C. and Carroll, Anthony R.
- Subjects
INDOLE alkaloids ,MARINE natural products ,STRUCTURE-activity relationships ,DRUG discovery ,NATURAL numbers ,ISOQUINOLINE alkaloids ,INDOLE - Abstract
Covering: marine indole alkaloids (n = 2048) and their reported bioactivities up to the end of 2021 Despite increasing numbers of marine natural products (MNPs) reported each year, most have only been examined for cytotoxic, antibacterial, and/or antifungal biological activities with the majority found to be inactive in these assays. In this context, why are natural products continuing to be examined in assays they are unlikely to show significant activity in, and what targets might be more useful for expanding knowledge of their biologically relevant chemical space? We have undertaken a meta-analysis of the biological activities for 2048 marine indole alkaloids (MIAs), a diverse sub-class of MNPs reported up to the end of 2021, and this has highlighted that the bioactivity potentials for up to 86% of published MIAs remains underexplored and/or undefined. Although most published MIAs are not cytotoxic or antimicrobial, there is a continued focus on using these assays to evaluate new structurally related analogues. Using cheminformatics analyses, the chemical diversity of the 2048 MIAs were clustered using fragment based fingerprints and their reported bioactivity potency towards specific disease targets was assessed for structure activity trends. These analyses showed that there are groups of MIAs that possess potent and diverse activities and that many analogues, previously tested only in cellular toxicity assays, could be better exploited to generate structure activity relationships associated with leads to treat emerging diseases. A collection of indole drug and drug-lead structures from non-natural sources were also incorporated into the dataset providing complementary bioactivity profiles that were further used to predict underexplored areas of potential new activity and to better direct future testing of MIAs. Our findings clearly suggest the biological evaluation of MIAs continues to be conducted on a narrow range of bioassays and disease targets, and that shifting the focus to non-toxic disease targets should provide expanded knowledge of biologically relevant chemical space aimed at maximising the potential of MIAs for drug discovery. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
46. Structural diversity, hypothetical biosynthesis, chemical synthesis, and biological activity of Ganoderma meroterpenoids.
- Author
-
Peng, Xing-Rong, Unsicker, Sybille B., Gershenzon, Jonathan, and Qiu, Ming-Hua
- Subjects
CHEMICAL synthesis ,GANODERMA ,BIOSYNTHESIS ,DOSAGE forms of drugs ,DRUG development - Abstract
Covering: 2018 to 2022 Meroterpenoids found in fungal species of the genus Ganoderma and known as Ganoderma meroterpenoids (GMs) are substances composed of a 1,2,4-trisubstituted benzene and a polyunsaturated side chain. These substances have attracted the attention of chemists and pharmacologists due to their diverse structures and significant bioactivity. In this review, we present the structures and possible biosynthesis of representative GMs newly found from 2018 to 2022, as well as chemical synthesis and biological activity of some interesting GMs. We propose for the first time a plausible biosynthetic pathway for GMs, which will certainly motivate further research on the biosynthetic pathway in Ganoderma species, as well as on chemical synthesis of GMs as important bioactive compounds for the purpose of drug development. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
47. Natural products of pentacyclic triterpenoids: from discovery to heterologous biosynthesis.
- Author
-
Li, Yanlin, Wang, Jing, Li, Linyong, Song, Wenhui, Li, Min, Hua, Xin, Wang, Yu, Yuan, Jifeng, and Xue, Zheyong
- Subjects
SAPONINS ,TRITERPENOIDS ,TRITERPENOID saponins ,NATURAL products ,DEVELOPMENTAL biology ,GENETIC transcription regulation ,SYNTHETIC biology ,BIOSYNTHESIS - Abstract
Covering: up to 2022 Pentacyclic triterpenoids are important natural bioactive substances that are widely present in plants and fungi. They have significant medicinal efficacy, play an important role in reducing blood glucose and protecting the liver, and have anti-inflammatory, anti-oxidation, anti-fatigue, anti-viral, and anti-cancer activities. Pentacyclic triterpenoids are derived from the isoprenoid biosynthetic pathway, which generates common precursors of triterpenes and steroids, followed by cyclization with oxidosqualene cyclases (OSCs) and decoration via cytochrome P450 monooxygenases (CYP450s) and glycosyltransferases (GTs). Many biosynthetic pathways of triterpenoid saponins have been elucidated by studying their metabolic regulation network through the use of multiomics and identifying their functional genes. Unfortunately, natural resources of pentacyclic triterpenoids are limited due to their low content in plant tissues and the long growth cycle of plants. Based on the understanding of their biosynthetic pathway and transcriptional regulation, plant bioreactors and microbial cell factories are emerging as alternative means for the synthesis of desired triterpenoid saponins. The rapid development of synthetic biology, metabolic engineering, and fermentation technology has broadened channels for the accumulation of pentacyclic triterpenoid saponins. In this review, we summarize the classification, distribution, structural characteristics, and bioactivity of pentacyclic triterpenoids. We further discuss the biosynthetic pathways of pentacyclic triterpenoids and involved transcriptional regulation. Moreover, the recent progress and characteristics of heterologous biosynthesis in plants and microbial cell factories are discussed comparatively. Finally, we propose potential strategies to improve the accumulation of triterpenoid saponins, thereby providing a guide for their future biomanufacturing. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
48. From plant to cancer drug: lessons learned from the discovery of taxol.
- Author
-
Cech, Nadja B. and Oberlies, Nicholas H.
- Subjects
MEDICAL botany ,PACLITAXEL ,DRUG discovery ,NATURAL products ,CAMPTOTHECIN - Abstract
Many researchers in the natural product sciences dream of discovering a successful drug. For almost all of us, this dream will never be realized. Among the heroes of our past, though, there is a team whose efforts led to the discovery of not one but two new drugs. Dr Monroe Wall and Dr Mansukh Wani isolated and solved the structures for taxol and camptothecin, plant-based compounds that continue to play a critical role in cancer therapy today. Since the 1960s and 1970s when Wall, Wani and collaborators did their seminal work, there have been tremendous technological advances in the natural product sciences. With access to most sophisticated technology, it might be expected that the rate of discovery of new drugs from plants and other sources would have sped up. However, this has not come to pass. Why is this? Is it that the promise of new drug candidates from plant-based sources has been exhausted? Has our fascination with new technologies and with the promise of the genomics revolution caused us to stop investing effort and resources in the practices that are proven to yield success? With this Viewpoint, we share the story of taxol's discovery, highlighting critical challenges that were overcome and considering their relevance to botanical natural products drug discovery today. We hope that consideration of lessons learned from the past will help fuel success by researchers currently studying plants with the goal of discovering promising therapeutic leads. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
49. Recent advances in the discovery of plant-derived antimicrobial natural products to combat antimicrobial resistant pathogens: insights from 2018–2022.
- Author
-
Woo, Sunmin, Marquez, Lewis, Crandall, William J., Risener, Caitlin J., and Quave, Cassandra L.
- Subjects
NATURAL products ,BIRTHPARENTS ,ANTI-infective agents ,PLANT products ,DRUG resistance in microorganisms - Abstract
Covering: 2018 to 2022 Antimicrobial resistance (AMR) poses a significant global health threat. There is a rising demand for innovative drug scaffolds and new targets to combat multidrug-resistant bacteria. Before the advent of antibiotics, infections were treated with plants chosen from traditional medicine practices. Of Earth's 374 000 plant species, approximately 9% have been used medicinally, but most species remain to be investigated. This review illuminates discoveries of antimicrobial natural products from plants covering 2018 to 2022. It highlights plant-derived natural products with antibacterial, antivirulence, and antibiofilm activity documented in lab studies. Additionally, this review examines the development of novel derivatives from well-studied parent natural products, as natural product derivatives have often served as scaffolds for anti-infective agents. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
50. Strategies for the discovery of potential anticancer agents from plants collected from Southeast Asian tropical rainforests as a case study.
- Author
-
Carcache de Blanco, Esperanza J., Addo, Ermias Mekuria, Rakotondraibe, H. Liva, Soejarto, Djaja D., and Kinghorn, A. Douglas
- Subjects
RAIN forests ,PLANT collecting ,DRUG discovery ,ANTINEOPLASTIC agents ,TROPICAL plants ,FRUIT extracts ,IDENTIFICATION - Abstract
Covering up to early 2023 The present review summarizes recent accomplishments made as part of a multidisciplinary, multi-institutional anticancer drug discovery project, wherein samples comprising higher plants were collected primarily from Southeast Asia, and also from Central America, and the West Indies. In the introductory paragraphs, a short perspective is provided on the current importance of plants in the discovery of cancer therapeutic agents, and the contributions of other groups working towards this objective are mentioned. For our own investigations, following their collection, tropical plants have been subjected to solvent extraction and biological evaluation for their antitumor potential. Several examples of purified plant lead bioactive compounds were obtained and characterized, and found to exhibit diverse structures, including those of the alkaloid, cardiac glycoside, coumarin, cucurbitacin, cyclobenzofuran (rocaglate), flavonoid, lignan, and terpenoid types. In order to maximize the efficiency of work on drug discovery from tropical plant species, strategies to optimize various research components have been developed, including those for the plant collections and taxonomic identification, in accordance with the requirements of contemporary international treaties and with a focus on species conservation. A major component of this aspect of the work is the development of collaborative research agreements with representatives of the source countries of tropical rainforest plants. The phytochemical aspects have included the preparation of plant extracts for initial screening and the selection of promising extracts for activity-guided fractionation. In an attempt to facilitate this process, a TOCSY-based NMR procedure has been applied for the determination of bioactive rocaglate derivatives in samples of Aglaia species (Meliaceae) collected for the project. Preliminary in vitro and in vivo mechanistic studies carried out by the authors are described for two tropical plant-derived bioactive lead compounds, corchorusoside C and (+)-betulin, including work conducted with a zebrafish (Danio rerio) model. In the concluding remarks, a number of lessons are summarized that our group has learned as a result of working on anticancer drug discovery using tropical plants, which we hope will be of interest to future workers. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
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