1. Water-Soluble Fullerenol with Hydroxyl Group Dependence for Efficient Two-Photon Excited Photodynamic Inactivation of Infectious Microbes
- Author
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Wen-Shuo Kuo, Jiu-Yao Wang, Chia-Yuan Chang, Jui-Chang Liu, Yu-Ting Shao, Yen-Sung Lin, Edmund Cheung So, and Ping-Ching Wu
- Subjects
Water-soluble fullerenol ,Composition of exposed hydroxyl groups ,Singlet oxygen quantum yield ,Reactive oxygen species ,Two-photon excitation ,Materials of engineering and construction. Mechanics of materials ,TA401-492 - Abstract
Abstract We successfully prepared water-soluble fullerenol [C60(OH)46] that exhibited a high singlet oxygen quantum yield and efficiently generated reactive oxygen species. Additionally, the water-soluble C60(OH)46 with a higher composition of exposed hydroxyl groups had superior two-photon stability and characteristics compared with that with a lower composition of such groups. Therefore, the prepared fullerenol can be an effective two-photon photosensitizer. The water-soluble C60(OH)46 had favorable two-photon properties. During two-photon photodynamic therapy, the water-soluble C60(OH)46 had substantial antimicrobial activity against Escherichia coli at an ultralow-energy level of 211.2 nJ pixel−1 with 800 scans and a photoexcited wavelength of 760 nm.
- Published
- 2020
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