Author: "P Vabre" / Journal: nanoscale - Searchworks@Jio Institute Digital Library Search Results

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Start Over Author "P Vabre" Journal nanoscale

Author: Durand, Jean-Olivier, Mongin, Olivier, Blanchard-Desce, Mireille, Zink, Jeffrey, Guardado-Alvarez, Tania, Devi, Lekshmi, Vabre, Jean-Marie, Pecorelli, Travis, and Schwartz, Benjamin
Subjects: Drug Carriers, Electron Transport, Infrared Rays, Nanoparticles, Oxidation-Reduction, Photons, Photosensitizing Agents, Porosity, Rhodamines, Silicon Dioxide
Abstract: We report the design and synthesis of a nano-container consisting of mesoporous silica nanoparticles with the pore openings covered by snap-top caps that are opened by near-IR light. A photo transducer molecule that is a reducing agent in an excited electronic state is covalently attached to the system. Near IR two-photon excitation causes inter-molecular electron transfer that reduces a disulfide bond holding the cap in place, thus allowing the cargo molecules to escape. We describe the operation of the snap-top release mechanism by both one- and two-photon activation. This system presents a proof of concept of a near-IR photoredox-induced nanoparticle delivery system that may lead to a new type of photodynamic drug release therapy.
Published: 2014

Author: Guardado-Alvarez, Tania M, Devi, Lekshmi Sudha, Vabre, Jean-Marie, Pecorelli, Travis A, Schwartz, Benjamin J, Durand, Jean-Olivier, Mongin, Olivier, Blanchard-Desce, Mireille, and Zink, Jeffrey I
Subjects: Nanotechnology, Bioengineering, Drug Carriers, Electron Transport, Infrared Rays, Nanoparticles, Oxidation-Reduction, Photons, Photosensitizing Agents, Porosity, Rhodamines, Silicon Dioxide, Physical Sciences, Chemical Sciences, Technology, Nanoscience & Nanotechnology
Abstract: We report the design and synthesis of a nano-container consisting of mesoporous silica nanoparticles with the pore openings covered by "snap-top" caps that are opened by near-IR light. A photo transducer molecule that is a reducing agent in an excited electronic state is covalently attached to the system. Near IR two-photon excitation causes inter-molecular electron transfer that reduces a disulfide bond holding the cap in place, thus allowing the cargo molecules to escape. We describe the operation of the "snap-top" release mechanism by both one- and two-photon activation. This system presents a proof of concept of a near-IR photoredox-induced nanoparticle delivery system that may lead to a new type of photodynamic drug release therapy.
Published: 2014

Author: Guardado-Alvarez, Tania M, Devi, Lekshmi Sudha, Vabre, Jean-Marie, Pecorelli, Travis A, Schwartz, Benjamin J, Durand, Jean-Olivier, Mongin, Olivier, Blanchard-Desce, Mireille, and Zink, Jeffrey I
Subjects: Silicon Dioxide, Rhodamines, Photosensitizing Agents, Drug Carriers, Infrared Rays, Electron Transport, Oxidation-Reduction, Photons, Porosity, Nanoparticles, Nanoscience & Nanotechnology, Technology, Physical Sciences, Chemical Sciences
Abstract: We report the design and synthesis of a nano-container consisting of mesoporous silica nanoparticles with the pore openings covered by "snap-top" caps that are opened by near-IR light. A photo transducer molecule that is a reducing agent in an excited electronic state is covalently attached to the system. Near IR two-photon excitation causes inter-molecular electron transfer that reduces a disulfide bond holding the cap in place, thus allowing the cargo molecules to escape. We describe the operation of the "snap-top" release mechanism by both one- and two-photon activation. This system presents a proof of concept of a near-IR photoredox-induced nanoparticle delivery system that may lead to a new type of photodynamic drug release therapy.
Published: 2014

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