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Your search keyword '"Pei, Jiahui"' showing total 5 results
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5 results on '"Pei, Jiahui"'

1. Mated-Atom Nanozymes with Efficient Assisted NAD+ Replenishment for Skin Regeneration

Author

Liu, Xiaoyu, primary, Wan, Zhen, additional, Chen, Ke, additional, Yan, Yuxing, additional, Li, Xuyan, additional, Wang, Yili, additional, Wang, Miaoyu, additional, Zhao, Ruoli, additional, Pei, Jiahui, additional, Zhang, Lijie, additional, Sun, Si, additional, Li, Jiarong, additional, Chen, Xinzhu, additional, Xin, Qi, additional, Zhang, Shaofang, additional, Liu, Shuangjie, additional, Wang, Hao, additional, Liu, Changlong, additional, Mu, Xiaoyu, additional, and Zhang, Xiao-Dong, additional

Published
2024
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3. Mated-Atom Nanozymes with Efficient Assisted NAD+Replenishment for Skin Regeneration

Author

Liu, Xiaoyu, Wan, Zhen, Chen, Ke, Yan, Yuxing, Li, Xuyan, Wang, Yili, Wang, Miaoyu, Zhao, Ruoli, Pei, Jiahui, Zhang, Lijie, Sun, Si, Li, Jiarong, Chen, Xinzhu, Xin, Qi, Zhang, Shaofang, Liu, Shuangjie, Wang, Hao, Liu, Changlong, Mu, Xiaoyu, and Zhang, Xiao-Dong

Abstract

Excessive accumulation of reduced nicotinamide adenine dinucleotide (NADH) within biological organisms is closely associated with many diseases. It remains a challenge to efficiently convert superfluous and detrimental NADH to NAD+. NADH oxidase (NOX) is a crucial oxidoreductase that catalyzes the oxidation of NADH to NAD+. Herein, M1M2(Mi=V/Mn/Fe/Co/Cu/Mo/Rh/Ru/Pd, i= 1 or 2) mated-atom nanozymes (MANs) are designed by mimicking natural enzymes with polymetallic active centers. Excitingly, RhCo MAN possesses excellent and sustainable NOX-like activity, with Km-NADH(16.11 µM) being lower than that of NOX-mimics reported so far. Thus, RhCo MAN can significantly promote the regeneration of NAD+and regulate macrophage polarization toward the M2 phenotype through down-regulation of TLR4 expression, which may help to recover skin regeneration. However, RhRu MAN with peroxidase-like activity and RhMn MAN with superoxide dismutase-like activity exhibit little modulating effects on eczema. This work provides a new strategy to inhibit skin inflammation and promote skin regeneration.

Published
2024
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4. Atomic Engineering of Clusterzyme for Relieving Acute Neuroinflammation through Lattice Expansion

Author

Sun, Si, primary, Liu, Haile, additional, Xin, Qi, additional, Chen, Ke, additional, Ma, Huizhen, additional, Liu, Shuhu, additional, Mu, Xiaoyu, additional, Hao, Wenting, additional, Liu, Shuangjie, additional, Gao, Yalong, additional, Wang, Yang, additional, Pei, Jiahui, additional, Zhao, Ruoli, additional, Zhang, Shaofang, additional, Zhang, Xiaoning, additional, Wang, Hao, additional, Li, Yonghui, additional, and Zhang, Xiao-Dong, additional

Published
2021
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5. Mated-Atom Nanozymes with Efficient Assisted NAD + Replenishment for Skin Regeneration.

Author

Liu X, Wan Z, Chen K, Yan Y, Li X, Wang Y, Wang M, Zhao R, Pei J, Zhang L, Sun S, Li J, Chen X, Xin Q, Zhang S, Liu S, Wang H, Liu C, Mu X, and Zhang XD

Abstract

Excessive accumulation of reduced nicotinamide adenine dinucleotide (NADH) within biological organisms is closely associated with many diseases. It remains a challenge to efficiently convert superfluous and detrimental NADH to NAD + . NADH oxidase (NOX) is a crucial oxidoreductase that catalyzes the oxidation of NADH to NAD + . Herein, M 1 M 2 (M i =V/Mn/Fe/Co/Cu/Mo/Rh/Ru/Pd, i = 1 or 2) mated-atom nanozymes (MANs) are designed by mimicking natural enzymes with polymetallic active centers. Excitingly, RhCo MAN possesses excellent and sustainable NOX-like activity, with K m-NADH (16.11 μM) being lower than that of NOX-mimics reported so far. Thus, RhCo MAN can significantly promote the regeneration of NAD + and regulate macrophage polarization toward the M2 phenotype through down-regulation of TLR4 expression, which may help to recover skin regeneration. However, RhRu MAN with peroxidase-like activity and RhMn MAN with superoxide dismutase-like activity exhibit little modulating effects on eczema. This work provides a new strategy to inhibit skin inflammation and promote skin regeneration.

Published
2024
Full Text
View/download PDF

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