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26 results on '"Oh, Sang-Hyun"'

2. Subwavelength Terahertz Resonance Imaging (STRING) for Molecular Fingerprinting

Author

Ha, Taewoo, primary, Yoo, Daehan, additional, Heo, Chaejeong, additional, Vidal-Codina, Ferran, additional, Nguyen, Ngoc-Cuong, additional, Sim, Kyung Ik, additional, Park, Sang Hyun, additional, Cha, Wujoon, additional, Park, Sungsu, additional, Peraire, Jaime, additional, Kim, Teun-Teun, additional, Lee, Young Hee, additional, and Oh, Sang-Hyun, additional

Published
2022
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8. High-Contrast Infrared Absorption Spectroscopy via Mass-Produced Coaxial Zero-Mode Resonators with Sub-10 nm Gaps

Author

Yoo, Daehan, primary, Mohr, Daniel A., additional, Vidal-Codina, Ferran, additional, John-Herpin, Aurelian, additional, Jo, Minsik, additional, Kim, Sunghwan, additional, Matson, Joseph, additional, Caldwell, Joshua D., additional, Jeon, Heonsu, additional, Nguyen, Ngoc-Cuong, additional, Martin-Moreno, Luis, additional, Peraire, Jaime, additional, Altug, Hatice, additional, and Oh, Sang-Hyun, additional

Published
2018
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10. Blood-Based Nanoparticle-Enhanced Quaking-Induced Conversion (Nano-QuIC): Inhibitor-Resistant Detection of Seeding Activity in Patients Diagnosed with Parkinson’s Disease

Author

Christenson, Peter R., Jeong, Hyeonjeong, Li, Manci, Ahn, Hyerim, Schmeichel, Ann M., Misra, Pinaki, Li, Danni, Savica, Rodolfo, Low, Phillip A., Singer, Wolfgang, Larsen, Peter A., Park, Hye Yoon, and Oh, Sang-Hyun

Abstract

A hallmark of α-synucleinopathies (e.g., Parkinson’s disease) is the misfolding and aggregation of α-synuclein in tissues and biological fluids. Protein amplification assays like real-time quaking-induced conversion (RT-QuIC) are sensitive yet currently limited to semi-invasive sample types such as cerebrospinal fluid because more accessible samples, such as blood, contain inhibitors. Here, we show that Nanoparticle-enhanced Quaking-induced Conversion (Nano-QuIC) can double the speed of reactions spiked with misfolded α-synuclein while increasing sensitivity 100-fold in human plasma. Nano-QuIC detected spike concentrations down to 90 pg/mL in lysed whole blood, while reactions without nanoparticles (RT-QuIC) failed to have any detection due to the presence of strong inhibitors. Moreover, Nano-QuIC showed increased seeding activity in plasma samples from Parkinson’s patients (n = 4) versus healthy controls (n = 4). This sets the groundwork for the noninvasive diagnostic use of Nano-QuIC, potentially enabling early disease detection and management through blood-based testing.

Published
2024
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26. Nanogap-enhanced infrared spectroscopy with template-stripped wafer-scale arrays of buried plasmonic cavities.

Author

Chen X, Ciracì C, Smith DR, and Oh SH

Abstract

We have combined atomic layer lithography and template stripping to produce a new class of substrates for surface-enhanced infrared absorption (SEIRA) spectroscopy. Our structure consists of a buried and U-shaped metal-insulator-metal waveguide whose folded vertical arms efficiently couple normally incident light. The insulator is formed by atomic layer deposition (ALD) of Al2O3 and precisely defines the gap size. The buried nanocavities are protected from contamination by a silicon template until ready for use and exposed by template stripping on demand. The exposed nanocavity generates strong infrared resonances, tightly confines infrared radiation into a gap that is as small as 3 nm (λ/3300), and creates a dense array of millimeter-long hotspots. After partial removal of the insulators, the gaps are backfilled with benzenethiol molecules, generating distinct Fano resonances due to strong coupling with gap plasmons, and a SEIRA enhancement factor of 10(5) is observed for a 3 nm gap. Because of the wafer-scale manufacturability, single-digit-nanometer control of the gap size via ALD, and long-term storage enabled by template stripping, our buried plasmonic nanocavity substrates will benefit broad applications in sensing and spectroscopy.

Published
2015
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