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Recent advances in miniaturized nano-based devices are rapidly extending the boundaries of biomedical technologies, particularly biosensors. Highly selective biosensors with the ability to simultaneously detect multiple targets were developed in recent years. The most eye-catching classifications of such biosensors coupled with the emergence of stimuli-responsive and CRISPR/Cas-sensitive systems. Furthermore, attractive features of wearable and implantable biosensors have led to the design of portable, remote controllable diagnostic systems for tackling healthcare challenges in every part of the world, especially in places with limited access to clinical resources. Nevertheless, there are still some barriers to widespread applications of biosensors due mainly to their high costs and the lack of a single biosensing device for highly selective targeting of multiple analytes. Herein, we review the latest developments in biomedical technologies with a focus on biosensors including smart stimuli-responsive, CRISPR/Cas-sensitive, wearable, and implantable biosensors to spark innovations in this field.

The present study outlines a straightforward approach for designing a novel drug delivery system based on bacterial nanocellulose composites containing curcumin-loaded graphene quantum dots (BNC/CUR/GQDs) for antibacterial and wound healing applications. The nanocomposite was made of interconnected plates with uniform thicknesses around 2[Formula: see text]mm. The scanning electron microscope (SEM) image of the prepared BNC nanocomposite showed a uniform and porous morphology composed of the microfibrils having an average diameter of 120[Formula: see text]nm, which contributes to both drug inclusion and drug release in a controllable fashion. The designed system biosynthesized by Acetobacter xylinum demonstrated an optimum drug loading capacity and controlled release profile. The drug loading content and drug release efficiency were calculated around 31% and 61%. Agar diffusion test indicated that the introduction of GQDs into the BNC matrix conspicuously improved the growth inhibition of bacteria, and gram-negative and gram-positive bacterial strains were measured 21.6[Formula: see text]mm and 21.5[Formula: see text]mm, respectively. The cell viability of 92.3% was obtained for the BNC, while the cell viability of the designed system was measured at around 88.07%. Consequently, the incorporation of curcumin-loaded graphene quantum dots into bacterial nanocellulose matrices can open up a new insight into the production of high-performance wound dressing supplies.