16 results on '"Eumycetoma"'
Search Results
2. Eumycetoma of the Foot due to Fusarium solani in a Person with Diabetes Mellitus: Report of a Case and Review of Literature.
- Author
-
Das, Liza, Dahiya, Divya, Gupta, Kirti, Prakash, Mahesh, Malhotra, Bhanu, Rastogi, Ashu, Choudhary, Hansraj, Rudramurthy, Shivaprakash M., and Dutta, Pinaki
- Abstract
Eumycetomas are chronic suppurative granulomas caused by fungi characterised by invasive tumefactive lesions, sinuses and discharging grains. Herein, we describe a case of pedal eumycetoma due to Fusarium solani sensu stricto in a person with diabetes mellitus. A 45-year-old gentleman presented with an insidious onset swelling over his right foot with nodules and discharging grains. He had received itraconazole and anti-tuberculous therapy elsewhere, without response. Re-evaluation included a biopsy which confirmed eumycetoma and newly diagnosed diabetes. Surgical excision followed by histopathological, microbiological and multigene sequencing analyses [translation elongation factor, calmodulin and internal transcribed spacer region of rDNA] of the mould on culture were performed. Histopathology revealed septate fungal hyphae amidst a dense inflammatory infiltrate (Splendore–Hoeppli) reaction. Oral voriconazole was started and good glycemic control attained. Tissue growth sequences showed > 99% similarity with Fusarium solani sensu stricto. Antifungal susceptibility testing showed lowest MIC to voriconazole (0.5 mg/L). The patient showed excellent response to combined therapeutic modality with a near-complete resolution in size of lesion and obliteration of sinuses following 4 months of therapy and is planned for prolonged voriconazole therapy till complete radiological resolution. Diabetes predisposes to fungal infections of foot but eumycetomas are uncommon. Combined surgery and antifungals can improve morbidity and avoid amputations. [ABSTRACT FROM AUTHOR]
- Published
- 2021
- Full Text
- View/download PDF
3. Mycetoma in China: A Case Report and Review of the Literature.
- Author
-
Wang, Ruojun, Yao, Xueyan, and Li, Ruoyu
- Abstract
Mycetoma is a chronic granulomatous infectious disease that can affect the skin, subcutaneous tissue, fascia and bone. It can be caused by filamentous bacteria or fungi and usually involves the legs and feet. Mycetoma is endemic in tropical and subtropical regions and is easily misdiagnosed in clinical practice because of its nonspecific clinical features and lack of awareness of the disease. Although mycetoma is very rare in mainland China, an increasing number of cases have been reported in recent years. Here, we report a case of mycetoma in a patient who was misdiagnosed many years before receiving the correct treatment, leading to disease progression and motion limitation. The grains that represent microorganismal colonies were important clues for diagnosis. We also reviewed reported cases of mycetoma in mainland China. The majority of cases were reported from southern regions. Actinomycetoma was more commonly reported than was eumycetoma. The causative agents of actinomycetoma included Nocardia brasiliensis, N. asteroides, N. otitidiscaviarum, N. ninae and Gordonia terrae, and the causative fungi of eumycetoma were identified as Madurella mycetomatis, Fonsecaea pedrosoi and Acremonium falciforme. Notably, the diagnosis of mycetoma was delayed from months to decades in all of the patients, likely due to a lack of clinical experience. Our literature review suggests the importance of increased awareness of mycetoma in clinical practice, especially in non-endemic regions. Further investigative studies are needed to determine the real incidence of the disease in China. [ABSTRACT FROM AUTHOR]
- Published
- 2019
- Full Text
- View/download PDF
4. Mycetoma in China: A Case Report and Review of the Literature
- Author
-
Ruojun Wang, Xueyan Yao, and Ruoyu Li
- Subjects
Adult ,Male ,0301 basic medicine ,China ,medicine.medical_specialty ,Gordonia terrae ,Veterinary (miscellaneous) ,030106 microbiology ,Eumycetoma ,Applied Microbiology and Biotechnology ,Microbiology ,Nocardia ,Young Adult ,030207 dermatology & venereal diseases ,03 medical and health sciences ,0302 clinical medicine ,medicine ,Humans ,skin and connective tissue diseases ,Aged ,Skin ,Microscopy ,integumentary system ,biology ,Nocardia brasiliensis ,Histocytochemistry ,business.industry ,Incidence ,Madurella mycetomatis ,Fungi ,Middle Aged ,medicine.disease ,biology.organism_classification ,Actinomycetoma ,Dermatology ,Fonsecaea pedrosoi ,Infectious disease (medical specialty) ,Mycetoma ,Female ,business ,Agronomy and Crop Science - Abstract
Mycetoma is a chronic granulomatous infectious disease that can affect the skin, subcutaneous tissue, fascia and bone. It can be caused by filamentous bacteria or fungi and usually involves the legs and feet. Mycetoma is endemic in tropical and subtropical regions and is easily misdiagnosed in clinical practice because of its nonspecific clinical features and lack of awareness of the disease. Although mycetoma is very rare in mainland China, an increasing number of cases have been reported in recent years. Here, we report a case of mycetoma in a patient who was misdiagnosed many years before receiving the correct treatment, leading to disease progression and motion limitation. The grains that represent microorganismal colonies were important clues for diagnosis. We also reviewed reported cases of mycetoma in mainland China. The majority of cases were reported from southern regions. Actinomycetoma was more commonly reported than was eumycetoma. The causative agents of actinomycetoma included Nocardia brasiliensis, N. asteroides, N. otitidiscaviarum, N. ninae and Gordonia terrae, and the causative fungi of eumycetoma were identified as Madurella mycetomatis, Fonsecaea pedrosoi and Acremonium falciforme. Notably, the diagnosis of mycetoma was delayed from months to decades in all of the patients, likely due to a lack of clinical experience. Our literature review suggests the importance of increased awareness of mycetoma in clinical practice, especially in non-endemic regions. Further investigative studies are needed to determine the real incidence of the disease in China.
- Published
- 2019
5. Eumycetoma of the Foot due to Fusarium solani in a Person with Diabetes Mellitus: Report of a Case and Review of Literature
- Author
-
Kirti Gupta, Bhanu Malhotra, Shivaprakash M Rudramurthy, Hansraj Choudhary, Mahesh Prakash, Liza Das, Pinaki Dutta, Ashu Rastogi, and Divya Dahiya
- Subjects
0301 basic medicine ,Male ,medicine.medical_specialty ,Antifungal Agents ,Itraconazole ,Veterinary (miscellaneous) ,030106 microbiology ,Eumycetoma ,Applied Microbiology and Biotechnology ,Microbiology ,Lesion ,030207 dermatology & venereal diseases ,03 medical and health sciences ,0302 clinical medicine ,Fusarium ,Diabetes mellitus ,Biopsy ,medicine ,Diabetes Mellitus ,Humans ,Voriconazole ,biology ,medicine.diagnostic_test ,business.industry ,Middle Aged ,medicine.disease ,biology.organism_classification ,Dermatology ,Mycetoma ,Histopathology ,medicine.symptom ,business ,Agronomy and Crop Science ,Fusarium solani ,medicine.drug - Abstract
Eumycetomas are chronic suppurative granulomas caused by fungi characterised by invasive tumefactive lesions, sinuses and discharging grains. Herein, we describe a case of pedal eumycetoma due to Fusarium solani sensu stricto in a person with diabetes mellitus. A 45-year-old gentleman presented with an insidious onset swelling over his right foot with nodules and discharging grains. He had received itraconazole and anti-tuberculous therapy elsewhere, without response. Re-evaluation included a biopsy which confirmed eumycetoma and newly diagnosed diabetes. Surgical excision followed by histopathological, microbiological and multigene sequencing analyses [translation elongation factor, calmodulin and internal transcribed spacer region of rDNA] of the mould on culture were performed. Histopathology revealed septate fungal hyphae amidst a dense inflammatory infiltrate (Splendore–Hoeppli) reaction. Oral voriconazole was started and good glycemic control attained. Tissue growth sequences showed > 99% similarity with Fusarium solani sensu stricto. Antifungal susceptibility testing showed lowest MIC to voriconazole (0.5 mg/L). The patient showed excellent response to combined therapeutic modality with a near-complete resolution in size of lesion and obliteration of sinuses following 4 months of therapy and is planned for prolonged voriconazole therapy till complete radiological resolution. Diabetes predisposes to fungal infections of foot but eumycetomas are uncommon. Combined surgery and antifungals can improve morbidity and avoid amputations.
- Published
- 2020
6. Eumycetoma of the Hand Caused by Leptosphaeria tompkinsii and Refractory to Medical Therapy with Voriconazole.
- Author
-
Cartwright, Katharine, Clark, Tristan, Hussain, Abid, Wiselka, Martin, Borman, Andrew, and Johnson, Elizabeth
- Abstract
We report on the first case of eumycetoma caused by the organism Leptosphaeria tompkinsii to be diagnosed and possibly acquired within the United Kingdom. Conventional culture of fungal grains and surgical tissue specimens was negative and the diagnosis was achieved using panfungal polymerase chain reaction and sequencing technology. Despite limited surgical resection and prolonged antifungal therapy with voriconazole, the patient developed progressive disease with mycetoma bone involvement. This case highlights the usefulness of molecular diagnostic techniques in eumycetoma where organisms may fail to grow with conventional culture or be difficult to identify morphologically. It also reminds us that eumycetoma is a difficult infection to treat and despite optimism regarding the efficacy of the newer triazole antifungals in this condition, treatment failures may still occur. [ABSTRACT FROM AUTHOR]
- Published
- 2011
- Full Text
- View/download PDF
7. Mycetoma caused by Fusarium solani with osteolytic lesions on the hand: case report.
- Author
-
Tomimori-Yamashita, Jane, Ogawa, Marília, Hirata, Sérgio, Fischman, Olga, Michalany, Nílceo, Yamashita, Hélio, and Alchorne, Maurício
- Abstract
Eumycetoma is a mycotic disease caused by saprophytic soil fungi that are usually inoculated through minor injuries. A case of mycetoma in a Brazilian farmer aged71 years is reported. This patient presented erythema and edema on the dorsal surface of the left hand with multiple crusted and cicatricial lesions. No macroscopic grains were observed. The histopathological findings showed grains consisted of numerous hyphae which stained well with Gomori-Grocott method. This material obtained by cutaneous biopsy was submitted to culture on Sabouraud’s medium and the colonies were identified as Fusarium solani. The radiological studies revealed bone osteolytic lesions and the ultrasound showed pseudocysts and fistulae at the site of this infection. The patient was treated with oral ketoconazole with a good clinical response. [ABSTRACT FROM AUTHOR]
- Published
- 2002
- Full Text
- View/download PDF
8. Eumycetoma caused by Curvularia lunata in a dog.
- Author
-
Elad, D., Orgad, U., Yakobson, B., Perl, S., Golomb, P., Trainin, R., Tsur, I., Shenkler, S., and Bor, A.
- Abstract
Curvularia lunata was cultured from black granules found in granulomatous tumefactions excised from the subcutis of a three year old Medium Schnauzer dog. Draining sinuses were present in some of the tumefactions. Accordingly the diagnosis of eumycotic mycetoma was made. This diagnosis was confirmed by histopathological examination. During the four years following the first surgical intervention, several more similar tumefactions were excised on three different occasions. The dog died of chronic renal failure at the age of 8 years. There was no bone involvement or visceral diffusion of the fungus. The granules were examined by scanning electron microscopy. Immunoglobulins in the dog's serum, assessed by a qualitative test, proved to be equal to immunoglobulins in the serum of a control dog. Precipitating antibodies against C. lunata were not found. The dog was treated for 150 days with itraconazole. In spite of good initial results, recurrence of the fungal lesions were observed after the treatment's interruption. Further treatment with itraconazole for 45 days proved ineffective. No side effects of the drug were observed. This is, to the best of our knowledge, the first case in which C. lunata is identified as the causative agent of an animal eumycetoma. [ABSTRACT FROM AUTHOR]
- Published
- 1991
- Full Text
- View/download PDF
9. Mycetoma in the Togolese: An Update from a Single-Center Experience
- Author
-
Vincent Palokinam Pitche, Mazamaesso Tchaou, Ameyo M. Dorkenoo, Tchin Darré, Bayaki Saka, Atchi Walla, Kwamé Doh, Abas Mouhari-Toure, Koffi Amegbor, and Gado Napo-Koura
- Subjects
0301 basic medicine ,Adult ,Male ,medicine.medical_specialty ,Adolescent ,Epidemiology ,Veterinary (miscellaneous) ,030231 tropical medicine ,030106 microbiology ,Eumycetoma ,Single Center ,Applied Microbiology and Biotechnology ,Microbiology ,03 medical and health sciences ,Young Adult ,0302 clinical medicine ,medicine ,Humans ,Actinomadura madurae ,Child ,Mycetomas ,Aged ,Retrospective Studies ,Original Paper ,biology ,Etiological agents ,business.industry ,Histocytochemistry ,Madurella mycetomatis ,Fungi ,Retrospective cohort study ,Middle Aged ,medicine.disease ,biology.organism_classification ,Actinomycetoma ,Dermatology ,Hospitals ,Actinobacteria ,Cross-Sectional Studies ,Mycetoma ,Togo ,Etiology ,Female ,business ,Agronomy and Crop Science - Abstract
Background Mycetoma is a chronic inflammatory process caused either by fungi (eumycetoma) or bacteria (actinomycetoma). In this retrospective study, we report epidemiologic and histopathological data of mycetoma observed in the Lome Hospital, Togo in a 25-year period (1992–2016). Methodology This is a retrospective study, over a period of 25 years, to analyze epidemiological and etiological findings of mycetomas seen in the single laboratory of pathological anatomy of the Lomé, Togo. Results A total of 61 cases were retrieved from which only 33 cases were included which where clinically and microbiologically confirmed. The mean age of the patients was 29.7 ± 1.34 and a sex ratio (M/F) of 1.5. The majority of patients were farmers (n = 23 cases; 69.7%). Diagnosed etiologic agents were fungal in 24 cases (72.7%) and actinomycotic cases in 9 cases (27.3%). The fungal mycetomas consisted of Madurella mycetomatis (black grains) and Falcifomispora senegaliensis (black grains). The actinomycotic agents were represented by Actinomadura madurae (white grains), Actinomadurae pelletieri (red grains) and Nocardia sp. (yellow grains). Conclusion This report represents a single-center study which provides epidemiologic and histopathological data of mycetoma cases in Togo.
- Published
- 2017
10. Mycetomas in Iran: a review article
- Author
-
Zarei Mahmoudabadi, Ali and Zarrin, Majid
- Published
- 2008
- Full Text
- View/download PDF
11. [Untitled]
- Author
-
Olga Fischman, Jane Tomimori-Yamashita, Maurício Mota de Avelar Alchorne, Hélio Kiitiro Yamashita, Marilia M. Ogawa, Nilceo Schwery Michalany, and Sergio Henrique Hirata
- Subjects
Pathology ,medicine.medical_specialty ,integumentary system ,medicine.diagnostic_test ,biology ,Erythema ,business.industry ,Veterinary (miscellaneous) ,food and beverages ,Fungi imperfecti ,Eumycetoma ,medicine.disease ,biology.organism_classification ,Applied Microbiology and Biotechnology ,Microbiology ,Lesion ,Edema ,Biopsy ,medicine ,Ketoconazole ,medicine.symptom ,business ,Agronomy and Crop Science ,Fusarium solani ,medicine.drug - Abstract
Eumycetoma is a mycotic disease caused by saprophytic soil fungi that are usually inoculated through minor injuries. A case of mycetoma in a Brazilian farmer aged 71 years is reported. This patient presented erythema and edema on the dorsal surface of the left hand with multiple crusted and cicatricial lesions. No macroscopic grains were observed. The histopathological findings showed grains consisted of numerous hyphae which stained well with Gomori-Grocott method. This material obtained by cutaneous biopsy was submitted to culture on Sabouraud's medium and the colonies were identified as Fusarium solani. The radiological studies revealed bone osteolytic lesions and the ultrasound showed pseudocysts and fistulae at the site of this infection. The patient was treated with oral ketoconazole with a good clinical response.
- Published
- 2002
12. A case of eumycetoma due to Madurella grisea in northern Brazil
- Author
-
Vilela, Raquel, Duarte, Olga M. V., Rosa, Carlos A., Castro, Joao G. F., Lyon, Sandra, Motta, Roberta L., and Moura, Ana C. L.
- Published
- 2004
- Full Text
- View/download PDF
13. Eumycetoma of the hand caused by Leptosphaeria tompkinsii and refractory to medical therapy with voriconazole
- Author
-
Tristan W Clark, Abid Hussain, Elizabeth M. Johnson, Martin Wiselka, Katharine E. Cartwright, and Andrew M. Borman
- Subjects
Male ,medicine.medical_specialty ,Antifungal Agents ,Veterinary (miscellaneous) ,Molecular Sequence Data ,Biology ,Eumycetoma ,Applied Microbiology and Biotechnology ,Microbiology ,Polymerase Chain Reaction ,Medical microbiology ,Refractory ,Ascomycota ,medicine ,Humans ,Treatment Failure ,DNA, Fungal ,Voriconazole ,Histocytochemistry ,Sequence Analysis, DNA ,Middle Aged ,Triazoles ,medicine.disease ,Hand ,Dermatology ,United Kingdom ,Surgery ,Leptosphaeria tompkinsii ,Pyrimidines ,Debridement ,Mycetoma ,Tomography, X-Ray Computed ,Agronomy and Crop Science ,Medical therapy ,Triazole antifungals ,Progressive disease ,medicine.drug - Abstract
We report on the first case of eumycetoma caused by the organism Leptosphaeria tompkinsii to be diagnosed and possibly acquired within the United Kingdom. Conventional culture of fungal grains and surgical tissue specimens was negative and the diagnosis was achieved using panfungal polymerase chain reaction and sequencing technology. Despite limited surgical resection and prolonged antifungal therapy with voriconazole, the patient developed progressive disease with mycetoma bone involvement. This case highlights the usefulness of molecular diagnostic techniques in eumycetoma where organisms may fail to grow with conventional culture or be difficult to identify morphologically. It also reminds us that eumycetoma is a difficult infection to treat and despite optimism regarding the efficacy of the newer triazole antifungals in this condition, treatment failures may still occur.
- Published
- 2010
14. Mycetomas in Iran: a review article
- Author
-
Majid Zarrin, Ali Zarei Mahmoudabadi, and Ali Zaree Mahmodabady
- Subjects
Adult ,Male ,Rural Population ,medicine.medical_specialty ,Pathology ,Veterinary (miscellaneous) ,Eumycetoma ,Iran ,Applied Microbiology and Biotechnology ,Microbiology ,Actinomycetales ,Prevalence ,Medicine ,Humans ,skin and connective tissue diseases ,Mycetoma ,Retrospective Studies ,integumentary system ,biology ,business.industry ,Age Factors ,Fungi ,Nocardia ,Middle Aged ,bacterial infections and mycoses ,biology.organism_classification ,medicine.disease ,Actinomycetoma ,Dermatology ,Mycoses ,Female ,business ,Male to female ,Agronomy and Crop Science ,Actinomycetales Infections ,Foot (unit) - Abstract
Mycetomas are the subcutaneous and relatively rare chronic pustular infections. The etio- logic agents of mycetomas are a group of saprophytic fungi and actinomycetes living in soil. We retrospec- tively discussed the overall prevalence of mycetomas and the prevalence of infective agents in Iran between 1972 and 2005. Seventy-six cases of mycetomas have been reported from various geographical locations in Iran during 33 years. Analysis of the records revealed that 84.5% were actinomycetoma and only 15.5% were eumycetoma. Disease mainly has been seen in foot, and the male to female ratio was 2:1. Myceto- mas were abundant among farmers in rural areas of Iran. The commonest agents of mycetomas were Nocardia asteroids, Actinomadura madura (actino- mycetoma) and Allesheria boydii (eumycetoma). The peak age of onset was between 31 and 51 years.
- Published
- 2007
15. A case of eumycetoma due to Madurella grisea in northern Brazil
- Author
-
Joao G. F. Castro, Ana C. L. Moura, Olga M. V. Duarte, Raquel Vilela, Roberta Leste Motta, Carlos A. Rosa, and Sandra Lyon
- Subjects
Adult ,Foot Dermatoses ,Male ,Veterinary medicine ,Antifungal Agents ,integumentary system ,biology ,Veterinary (miscellaneous) ,Madurella ,food and beverages ,Madurella grisea ,Eumycetoma ,biology.organism_classification ,medicine.disease ,Applied Microbiology and Biotechnology ,Microbiology ,Mycetoma ,medicine ,Humans ,Agronomy and Crop Science ,Foot (unit) ,Brazil - Abstract
A case of mycetoma caused by the black fungus Madurella grisea in northern Brazil is reported. The lesion was located on the patient's right foot without bone involvement. Clinical samples were collected by opening the fistules with a scalp and the grains removed for microbiological and histopathological analyses. Although mycetoma caused by M. grisea has been previously reported in Brazil, this is the first time that of this fungus has been identify in this particular region of the country.
- Published
- 2004
16. Eumycetoma caused by Curvularia lunata in a dog
- Author
-
R. Trainin, P. Golomb, S. Perl, D. Elad, A. Bor, I. Tsur, U Orgad, S. Shenkler, and B. Yakobson
- Subjects
Curvularia lunata ,Male ,Pathology ,medicine.medical_specialty ,Itraconazole ,Veterinary (miscellaneous) ,Schnauzer ,Eumycetoma ,Applied Microbiology and Biotechnology ,Microbiology ,Dogs ,Eumycotic mycetoma ,medicine ,Animals ,Dog Diseases ,Mycosis ,Granuloma ,biology ,biology.organism_classification ,medicine.disease ,Precipitating antibodies ,Ketoconazole ,Mycetoma ,Microscopy, Electron, Scanning ,Chronic renal failure ,Mitosporic Fungi ,Agronomy and Crop Science ,medicine.drug - Abstract
Curvularia lunata was cultured from black granules found in granulomatous tumefactions excised from the subcutis of a three year old Medium Schnauzer dog. Draining sinuses were present in some of the tumefactions. Accordingly the diagnosis of eumycotic mycetoma was made. This diagnosis was confirmed by histopathological examination. During the four years following the first surgical intervention, several more similar tumefactions were excised on three different occasions. The dog died of chronic renal failure at the age of 8 years. There was no bone involvement or visceral diffusion of the fungus. The granules were examined by scanning electron microscopy. Immunoglobulins in the dog's serum, assessed by a qualitative test, proved to be equal to immunoglobulins in the serum of a control dog. Precipitating antibodies against C. lunata were not found. The dog was treated for 150 days with itraconazole. In spite of good initial results, recurrence of the fungal lesions were observed after the treatment's interruption. Further treatment with itraconazole for 45 days proved ineffective. No side effects of the drug were observed. This is, to the best of our knowledge, the first case in which C. lunata is identified as the causative agent of an animal eumycetoma.
- Published
- 1991
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