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Your search keyword '"Granziera, Cristina"' showing total 9 results
Start Over Author "Granziera, Cristina" Journal multiple sclerosis journal
9 results on '"Granziera, Cristina"'

1. Use of pragmatic randomized trials in multiple sclerosis: A systematic overview

Author

Hirt, Julian, primary, Janiaud, Perrine, additional, Düblin, Pascal, additional, Nicoletti, Giovanni Jacopo, additional, Dembowska, Kinga, additional, Nguyen, Thao Vy Thi, additional, Woelfle, Tim, additional, Axfors, Cathrine, additional, Yaldizli, Özgür, additional, Granziera, Cristina, additional, Kuhle, Jens, additional, Kappos, Ludwig, additional, and Hemkens, Lars G, additional

Published
2024
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2. Optical coherence tomography versus other biomarkers: Associations with physical and cognitive disability in multiple sclerosis

Author

Cerdá-Fuertes, Nuria, primary, Stoessel, Marc, additional, Mickeliunas, Gintaras, additional, Pless, Silvan, additional, Cagol, Alessandro, additional, Barakovic, Muhamed, additional, Maceski, Aleksandra Maleska, additional, Álvarez González, Cesar, additional, D’ Souza, Marcus, additional, Schaedlin, Sabine, additional, Benkert, Pascal, additional, Calabrese, Pasquale, additional, Gugleta, Konstantin, additional, Derfuss, Tobias, additional, Sprenger, Till, additional, Granziera, Cristina, additional, Naegelin, Yvonne, additional, Kappos, Ludwig, additional, Kuhle, Jens, additional, and Papadopoulou, Athina, additional

Published
2023
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3. Anterior horn atrophy in the cervical spinal cord: A new biomarker in progressive multiple sclerosis

Author

Tsagkas, Charidimos, primary, Huck-Horvath, Antal, additional, Cagol, Alessandro, additional, Haas, Tanja, additional, Barakovic, Muhamed, additional, Amann, Michael, additional, Ruberte, Esther, additional, Melie-Garcia, Lester, additional, Weigel, Matthias, additional, Pezold, Simon, additional, Schlaeger, Regina, additional, Kuhle, Jens, additional, Sprenger, Till, additional, Kappos, Ludwig, additional, Bieri, Oliver, additional, Cattin, Philippe, additional, Granziera, Cristina, additional, and Parmar, Katrin, additional

Published
2022
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4. Paramagnetic rims are a promising diagnostic imaging biomarker in multiple sclerosis

Author

Meaton, Isobel, primary, Altokhis, Amjad, additional, Allen, Christopher Martin, additional, Clarke, Margareta A, additional, Sinnecker, Tim, additional, Meier, Dominik, additional, Enzinger, Christian, additional, Calabrese, Massimiliano, additional, De Stefano, Nicola, additional, Pitiot, Alain, additional, Giorgio, Antonio, additional, Schoonheim, Menno M, additional, Paul, Friedemann, additional, Pawlak, Mikolaj A, additional, Schmidt, Reinhold, additional, Granziera, Cristina, additional, Kappos, Ludwig, additional, Montalban, Xavier, additional, Rovira, Àlex, additional, Wuerfel, Jens, additional, and Evangelou, Nikos, additional

Published
2022
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5. Anterior horn atrophy in the cervical spinal cord: A new biomarker in progressive multiple sclerosis.

Author

Tsagkas, Charidimos, Huck-Horvath, Antal, Cagol, Alessandro, Haas, Tanja, Barakovic, Muhamed, Amann, Michael, Ruberte, Esther, Melie-Garcia, Lester, Weigel, Matthias, Pezold, Simon, Schlaeger, Regina, Kuhle, Jens, Sprenger, Till, Kappos, Ludwig, Bieri, Oliver, Cattin, Philippe, Granziera, Cristina, and Parmar, Katrin

Subjects
SPINAL cord, CERVICAL cord, MULTIPLE sclerosis, SUPERIOR colliculus, GRAY matter (Nerve tissue), WHITE matter (Nerve tissue)
Abstract

Background: Spinal cord (SC) gray and white matter pathology plays a central role in multiple sclerosis (MS). Objective: We aimed to investigate the extent, pattern, and clinical relevance of SC gray and white matter atrophy in vivo. Methods: 39 relapsing–remitting patients (RRMS), 40 progressive MS patients (PMS), and 24 healthy controls (HC) were imaged at 3T using the averaged magnetization inversion recovery acquisitions sequence. Total and lesional cervical gray and white matter, and posterior (SCPH) and anterior horn (SCAH) areas were automatically quantified. Clinical assessment included the expanded disability status scale, timed 25-foot walk test, nine-hole peg test, and the 12-item MS walking scale. Results: PMS patients had significantly reduced cervical SCAH — but not SCPH — areas compared with HC and RRMS (both p < 0.001). In RRMS and PMS, the cervical SCAH areas increased significantly less in the region of cervical SC enlargement compared with HC (all p < 0.001). This reduction was more pronounced in PMS compared with RRMS (both p < 0.001). In PMS, a lower cervical SCAH area was the most important magnetic resonance imaging (MRI)-variable for higher disability scores. Conclusion: MS patients show clinically relevant cervical SCAH atrophy, which is more pronounced in PMS and at the level of cervical SC enlargement. [ABSTRACT FROM AUTHOR]

Published
2023
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6. CSF chitinase 3-like 1 is associated with iron rims in patients with a first demyelinating event

Author

Comabella, Manuel, primary, Clarke, Margareta A, additional, Schaedelin, Sabine, additional, Tintoré, Mar, additional, Pareto, Deborah, additional, Fissolo, Nicolás, additional, Pinteac, Rucsanda, additional, Granziera, Cristina, additional, Sastre-Garriga, Jaume, additional, Benkert, Pascal, additional, Auger, Cristina, additional, Kuhle, Jens, additional, Montalban, Xavier, additional, and Rovira, Alex, additional

Published
2021
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8. CSF chitinase 3-like 1 is associated with iron rims in patients with a first demyelinating event.

Author

Comabella, Manuel, Clarke, Margareta A, Schaedelin, Sabine, Tintoré, Mar, Pareto, Deborah, Fissolo, Nicolás, Pinteac, Rucsanda, Granziera, Cristina, Sastre-Garriga, Jaume, Benkert, Pascal, Auger, Cristina, Kuhle, Jens, Montalban, Xavier, and Rovira, Alex

Subjects
GLIAL fibrillary acidic protein, CHITINASE, IRON, ENZYME-linked immunosorbent assay
Abstract

Background: Chronic active lesions with iron rims have prognostic implications in patients with multiple sclerosis. Objective: To assess the relationship between iron rims and levels of chitinase 3-like 1 (CHI3L1), neurofilament light chain (NfL) and glial fibrillary acidic protein (GFAP) in patients with a first demyelinating event. Methods: Iron rims were identified using 3T susceptibility-weighted imaging. Serum NfL and GFAP levels were measured by single-molecule array assays. CSF (cerebrospinal fluid) CHI3L1 levels were measured by enzyme-linked immunosorbent assay (ELISA). Results: Sixty-one patients were included in the study. The presence of iron rims was associated with higher T2 lesion volume and higher number of gadolinium-enhancing lesions. In univariable analysis, having ⩾2 iron rims (vs 0) was associated with increased CSF CHI3L1 levels (β = 1.41; 95% confidence interval (CI) = 1.10–1.79; p < 0.01) and serum NfL levels (β = 2.30; 95% CI = 1.47–3.60; p < 0.01). In multivariable analysis, however, only CSF CHI3L1 levels remained significantly associated with the presence of iron rim lesions (β = 1.45; 95% CI = 1.11–1.90; p < 0.01). The presence of ⩾2 iron rims was not associated with increased serum GFAP levels in univariable or multivariable analyses. Conclusion: These findings support an important contribution of activated microglia/macrophages to the pathophysiology of chronic active lesions with iron rims in patients with a first demyelinating event. [ABSTRACT FROM AUTHOR]

Published
2022
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9. Serum neurofilament light chain in early relapsing remitting MS is increased and correlates with CSF levels and with MRI measures of disease severity

Author

Kuhle, Jens, primary, Barro, Christian, additional, Disanto, Giulio, additional, Mathias, Amandine, additional, Soneson, Charlotte, additional, Bonnier, Guillaume, additional, Yaldizli, Özguer, additional, Regeniter, Axel, additional, Derfuss, Tobias, additional, Canales, Mathieu, additional, Schluep, Myriam, additional, Du Pasquier, Renaud, additional, Krueger, Gunnar, additional, and Granziera, Cristina, additional

Published
2016
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