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1. Impact of COVID-19 on pregnancy and fetal outcomes in women with multiple sclerosis.

Author

Aprea, Maria Grazia, Schiavetti, Irene, Portaccio, Emilio, Ballerini, Chiara, Bonavita, Simona, Buscarinu, Maria, Calabrese, Massimiliano, Cavalla, Paola, Cellerino, Maria, Cordioli, Cinzia, Dattola, Vincenzo, De Biase, Stefano, De Meo, Ermelinda, Fantozzi, Roberta, Gallo, Antonio, Iasevoli, Luigi, Karabudak, Rana, Landi, Doriana, Lorefice, Lorena, and Moiola, Lucia

Subjects
PREGNANCY outcomes, COVID-19 pandemic, PREGNANT women, MULTIPLE sclerosis, PREGNANCY complications
Abstract

Background: In the general population, maternal COVID-19 is associated with worse maternal and fetal outcomes. Two previous studies have assessed COVID-19 clinical outcomes in pregnant women with multiple sclerosis (MS), but there are no data about maternal and fetal outcomes. Objectives: In this multicenter study, we aimed to assess maternal and fetal outcomes in pregnant women with MS and COVID-19 infection. Methods: We recruited pregnant patients with MS who contracted COVID-19 and were followed up in Italian and Turkish Centers, during 2020–2022. A control group was extracted from a previous Italian cohort. Associations between group (COVID-19 or healthy patients) and clinical outcomes (maternal complications, fetal malformations, and spontaneous abortion) were investigated with a weighted logistic regression where propensity score–based inverse probability of treatment weighting (IPTW) approach was applied for adjusting for difference in baseline confounders. Results: In the multivariable analysis, COVID-19 during pregnancy was associated with a higher risk of maternal complications (odd ratio (OR) = 2.12; 95% confidence interval (CI) = 1.32–3.48; p = 0.002), while it was not associated with higher risk of spontaneous abortion and fetal malformations. Conclusion: Our data indicate that COVID-19 during pregnancy increases the risk of maternal complications, while it seems to have no significant impact on fetal outcomes. [ABSTRACT FROM AUTHOR]

Published
2024
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4. Breakthrough SARS-CoV-2 infections in MS patients on disease-modifying therapies

Author

Schiavetti, Irene, primary, Cordioli, Cinzia, additional, Stromillo, Maria Laura, additional, Teresa Ferrò, Maria, additional, Laroni, Alice, additional, Cocco, Eleonora, additional, Cola, Gaia, additional, Pasquali, Livia, additional, Rilla, Maria Teresa, additional, Signoriello, Elisabetta, additional, Iodice, Rosa, additional, Di Sapio, Alessia, additional, Lanzillo, Roberta, additional, Caleri, Francesca, additional, Annovazzi, Pietro, additional, Conte, Antonella, additional, Liberatore, Giuseppe, additional, Ruscica, Francesca, additional, Docimo, Renato, additional, Bonavita, Simona, additional, Ulivelli, Monica, additional, Cavalla, Paola, additional, Patti, Francesco, additional, Ferraro, Diana, additional, Clerico, Marinella, additional, Immovilli, Paolo, additional, Di Filippo, Massimiliano, additional, Salvetti, Marco, additional, and Sormani, Maria Pia, additional

Published
2022
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5. Hemostatic factors in the pathogenesis of neuroinflammation in multiple sclerosis.

Author

Abbadessa, Gianmarco, Lavorgna, Luigi, Treaba, Constantina Andrada, Bonavita, Simona, and Mainero, Caterina

Subjects
MULTIPLE sclerosis, NEUROINFLAMMATION, PATHOGENESIS, PROGNOSIS, DRUG target
Abstract

Background: A growing body of evidence has shed light on the role of the hemostatic pathway and its components in the pathogenesis of multiple sclerosis (MS), particularly in enhancing and sustaining neuroinflammation. Objective: To review the clinical, experimental, and neuroimaging evidence supporting the role of different components of the hemostatic pathway in the pathogenesis of neuroinflammation in MS and discuss their translational potential as disease biomarkers and therapeutic targets. Methods: A literature search for most relevant articles from 1956 to 2020 was conducted in PubMed and Scopus. Results: Hemostasis components appear to be involved in different key events of neuroinflammation in MS including mononuclear cell diapedesis, microglia activation, and neuronal damage. Conclusion: The findings on the interplay between hemostatic and thrombotic molecular pathways in the pathogenesis of neuroinflammation in MS open new opportunities for developing novel biomarkers for disease monitoring and prognosis, as well as novel therapeutic targets. [ABSTRACT FROM AUTHOR]

Published
2022
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7. SARS-CoV-2 serology after COVID-19 in multiple sclerosis: An international cohort study

Author

Sormani, Maria Pia, primary, Schiavetti, Irene, additional, Landi, Doriana, additional, Carmisciano, Luca, additional, De Rossi, Nicola, additional, Cordioli, Cinzia, additional, Moiola, Lucia, additional, Radaelli, Marta, additional, Immovilli, Paolo, additional, Capobianco, Marco, additional, Brescia Morra, Vincenzo, additional, Trojano, Maria, additional, Tedeschi, Gioacchino, additional, Comi, Giancarlo, additional, Battaglia, Mario Alberto, additional, Patti, Francesco, additional, Fragoso, Yara Dadalti, additional, Sen, Sedat, additional, Siva, Aksel, additional, Furlan, Roberto, additional, Salvetti, Marco, additional, Abbadessa, Gianmarco, additional, Aguglia, Umberto, additional, Allegorico, Lia, additional, Allegri, Rossi Beatrice Maria, additional, Amato, Maria Pia, additional, Annovazzi, Pietro, additional, Antozzi, Carlo, additional, Appendino, Lucia, additional, Arena, Sebastiano, additional, Baione, Viola, additional, Balgera, Roberto, additional, Barcella, Valeria, additional, Baroncini, Damiano, additional, Barrilà, Caterina, additional, Battaglia, Mario A., additional, Bellacosa, Alessandra, additional, Bellucci, Gianmarco, additional, Bergamaschi, Roberto, additional, Bergamaschi, Valeria, additional, Bezzini, Daiana, additional, Biolzi, Beatrice, additional, Bisecco, Alvino, additional, Bonavita, Simona, additional, Borriello, Giovanna, additional, Bosa, Chiara, additional, Bosco, Antonio, additional, Bovis, Francesca, additional, Bozzali, Marco, additional, Brambilla, Laura, additional, Brescia, Morra Vincenzo, additional, Brichetto, Giampaolo, additional, Buccafusca, Maria, additional, Bucciantini, Elisabetta, additional, Bucello, Sebastiano, additional, Buscarinu, Maria Chiara, additional, Cabboi, Maria Paola, additional, Calabrese, Massimiliano, additional, Calabria, Francesca, additional, Caleri, Francesca, additional, Camilli, Federico, additional, Caniatti, Luisa Maria, additional, Cantello, Roberto, additional, Capra, Ruggero, additional, Capuano, Rocco, additional, Carta, Patrizia, additional, Cavalla, Paola, additional, Celani, Maria Grazia, additional, Cellerino, Maria, additional, Cerqua, Raffaella, additional, Chisari, Clara, additional, Clerici, Raffaella, additional, Clerico, Marinella, additional, Cocco, Eleonora, additional, Cola, Gaia, additional, Confalonieri, Paolo, additional, Conte, Antonella, additional, Conti, Marta Zaffira, additional, Cordano, Christian, additional, Cordera, Susanna, additional, Corea, Francesco, additional, Correale, Claudio, additional, Cottone, Salvatore, additional, Crescenzo, Francesco, additional, Curti, Erica, additional, d’Ambrosio, Alessandro, additional, D’Amico, Emanuele, additional, Danni, Maura Chiara, additional, d’Arma, Alessia, additional, Dattola, Vincenzo, additional, de Biase, Stefano, additional, De Luca, Giovanna, additional, De Mercanti, Stefania Federica, additional, De Mitri, Paolo, additional, De Stefano, Nicola, additional, Della Cava, Marco, additional, di Napoli, Mario, additional, Di Sapio, Alessia, additional, Docimo, Renato, additional, Dutto, Anna, additional, Evangelista, Luana, additional, Fanara, Salvatore, additional, Ferraro, Diana, additional, Ferrò, Maria Teresa, additional, Filippi, Massimo, additional, Fioretti, Cristina, additional, Fratta, Mario, additional, Frau, Jessica, additional, Fronza, Marzia, additional, Gajofatto, Alberto, additional, Gallo, Antonio, additional, Gallo, Paolo, additional, Gasperini, Claudio, additional, Ghazaryan, Anna, additional, Giometto, Bruno, additional, Gobbin, Francesca, additional, Govone, Flora, additional, Granella, Franco, additional, Grange, Erica, additional, Grasso, Maria Grazia, additional, Guareschi, Angelica, additional, Guaschino, Clara, additional, Guerrieri, Simone, additional, Guidetti, Donata, additional, Iaffaldano, Pietro, additional, Ianniello, Antonio, additional, Iasevoli, Luigi, additional, Imperiale, Daniele, additional, Infante, Maria Teresa, additional, Inglese, Matilde, additional, Iodice, Rosa, additional, Iovino, Aniello, additional, Konrad, Giovanna, additional, Lanzillo, Roberta, additional, Lapucci, Caterina, additional, Lavorgna, Luigi, additional, L’Episcopo Maria, Rita, additional, Leva, Serena, additional, Liberatore, Giuseppe, additional, Lo Re, Marianna, additional, Longoni, Marco, additional, Lopiano, Leonardo, additional, Lorefice, Lorena, additional, Lucchini, Matteo, additional, Lus, Giacomo, additional, Maimone, Davide, additional, Malentacchi, Maria, additional, Mallucci, Giulia, additional, Malucchi, Simona, additional, Mancinelli, Chiara Rosa, additional, Mancinelli, Luca, additional, Manganotti, Paolo, additional, Maniscalco, Teresa Giorgia, additional, Mantero, Vittorio, additional, Marangoni, Sabrina, additional, Marastoni, Damiano, additional, Marfia, Alessandra Girolama, additional, Marinelli, Fabiana, additional, Marti, Alessandro, additional, Martinelli Boneschi, Filippo, additional, Masserano Zoli, Federco, additional, Matta, Francesca, additional, Mendozzi, Laura, additional, Meucci, Giuseppe, additional, Miante, Silvia, additional, Miele, Giuseppina, additional, Milano, Eva, additional, Mirabella, Massimiliano, additional, Missione, Rosanna, additional, Moccia, Marcello, additional, Montepietra, Sara, additional, Monti Bragadin, Margherita, additional, Montini, Federico, additional, Motta, Roberta, additional, Nardone, Raffaele, additional, Nicoletti, Carolina Gabri, additional, Nobile-Orazio, Eduardo, additional, Nozzolillo, Agostino, additional, Onofrj, Marco, additional, Orlandi, Riccardo, additional, Palmieri, Anna, additional, Paolicelli, Damiano, additional, Pasquali, Livia, additional, Pastò, Luisa, additional, Pedrazzoli, Elisabetta, additional, Perini, Paola, additional, Pesci, Ilaria, additional, Petracca, Maria, additional, Petrone, Alfredo, additional, Piantadosi, Carlo, additional, Pietroboni, Anna M., additional, Pinardi, Federica, additional, Ponzano, Marta, additional, Portaccio, Emilio, additional, Pozzato, Mattia, additional, Pozzilli, Carlo, additional, Prosperini, Luca, additional, Protti, Alessandra, additional, Ragonese, Paolo, additional, Rasia, Sarah, additional, Realmuto, Sabrina, additional, Repice, Anna, additional, Rigoni, Eleonora, additional, Rilla, Maria Teresa, additional, Rinaldi, Francesca, additional, Romano, Calogero Marcello, additional, Ronzoni, Marco, additional, Rovaris, Marco, additional, Ruscica, Francesca, additional, Sabattini, Loredana, additional, Salemi, Giuseppe, additional, Saraceno, Lorenzo, additional, Sartori, Alessia, additional, Sartori, Arianna, additional, Sbragia, Elvira, additional, Scandellari, Cinzia, additional, Scarano Giuditta, Ilaria, additional, Scarano, Valentina, additional, Schillaci, Valentina, additional, Sessa, Maria, additional, Sgarito, Caterina, additional, Sibilia, Grazia, additional, Siciliano, Gabriele, additional, Signori, Alessio, additional, Signoriello, Elisabetta, additional, Sinisi, Leonardo, additional, Sireci, Francesca, additional, Sola, Patrizia, additional, Solaro, Claudio, additional, Sormani, Maria Pia, additional, Sotgiu, Stefano, additional, Sparaco, Maddalena, additional, Stromillo, Maria Laura, additional, Strumia, Silvia, additional, Susani, Laura Emanuela, additional, Tabiadon, Giulietta, additional, Teatini, Francesco, additional, Tomassini, Valentina, additional, Tonietti, Simone, additional, Torri, Clerici Valentina, additional, Tortorella, Carla, additional, Toscano, Simona, additional, Totaro, Rocco, additional, Trotta, Maria, additional, Turano, Gabriella, additional, Ulivelli, Monica, additional, Valentino, Manzo, additional, Vaula, Giovanna, additional, Vecchio, Domizia, additional, Vercellino, Marco, additional, Verrengia, Elena Pinuccia, additional, Vianello, Marika, additional, Virgilio, Eleonora, additional, Vitetta, Francesca, additional, Vollaro, Stefano, additional, Zaffaroni, Mauro, additional, Zampolini, Mauro, additional, Zarbo, Ignazio Roberto, additional, Zito, Antonio, additional, and Zuliani, Luigi, additional

Published
2021
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8. Switch from sequestering to anti-CD20 depleting treatment: disease activity outcomes during wash-out and in the first 6 months of ocrelizumab therapy

Author

Signoriello, Elisabetta, primary, Lus, Giacomo, additional, Bonavita, Simona, additional, Lanzillo, Roberta, additional, Saccà, Francesco, additional, Landi, Doriana, additional, Frau, Jessica, additional, Baroncini, Damiano, additional, Zaffaroni, Mauro, additional, Maniscalco, Giorgia Teresa, additional, Curti, Erica, additional, Sartori, Arianna, additional, Cepparulo, Simone, additional, Marfia, Girolama Alessandra, additional, Nicoletti, Carolina Gabri, additional, Carotenuto, Antonio, additional, Nociti, Viviana, additional, Caleri, Francesca, additional, Sormani, Maria Pia, additional, and Signori, Alessio, additional

Published
2021
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9. Switch from sequestering to anti-CD20 depleting treatment: disease activity outcomes during wash-out and in the first 6 months of ocrelizumab therapy.

Author

Signoriello, Elisabetta, Lus, Giacomo, Bonavita, Simona, Lanzillo, Roberta, Saccà, Francesco, Landi, Doriana, Frau, Jessica, Baroncini, Damiano, Zaffaroni, Mauro, Maniscalco, Giorgia Teresa, Curti, Erica, Sartori, Arianna, Cepparulo, Simone, Marfia, Girolama Alessandra, Nicoletti, Carolina Gabri, Carotenuto, Antonio, Nociti, Viviana, Caleri, Francesca, Sormani, Maria Pia, and Signori, Alessio

Subjects
THERAPEUTICS, MAGNETIC resonance imaging, LYMPHOCYTE count, DISEASE relapse, MULTIPLE sclerosis
Abstract

Objectives: Switching between treatments is an opportunity for patients with multiple sclerosis (MS) to ameliorate disease control or safety. The aim of this study was to investigate the impact of switching from fingolimod (FTY) or natalizumab (NTZ) to ocrelizumab (OCR) on disease activity. Methods: We retrospectively enrolled 165 patients treated with OCR from 11 MS centres. We assessed the association of demographic and clinical characteristics on relapse rate (RR) and activity on magnetic resonance imaging (MRI) during wash-out and after 6 months of treatment with OCR through univariable and multivariable negative binomial regression models. Results: We registered a total of 35 relapses during the wash-out period. Previous treatment with FTY, relapses in the previous year, and relapsing-remitting course were associated with higher RR. In the first 6 months of OCR, 12 patients had clinical or MRI disease activity. Higher Expanded Disability Status Scale (EDSS) and higher lymphocyte count at OCR start were associated with a reduced probability of relapse. Discussion and Conclusion: This study confirms that withdrawal from sequestering agents as FTY increases the risk of relapses in the wash-out period. Nevertheless, starting OCR before achieving complete immune reconstitution could limit its effectiveness in the first 6 months probably because trapped lymphocytes escape the CD20-mediated depletion. [ABSTRACT FROM AUTHOR]

Published
2022
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10. Regional changes in thalamic shape and volume are related to cognitive performance in multiple sclerosis

Author

Bisecco, Alvino, primary, Capuano, Rocco, additional, Caiazzo, Giuseppina, additional, d’Ambrosio, Alessandro, additional, Docimo, Renato, additional, Cirillo, Mario, additional, Russo, Antonio, additional, Altieri, Manuela, additional, Bonavita, Simona, additional, Rocca, Maria A, additional, Filippi, Massimo, additional, Tedeschi, Gioacchino, additional, and Gallo, Antonio, additional

Published
2019
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11. Treatment of multiple sclerosis with rituximab: A multicentric Italian–Swiss experience

Author

Zecca, Chiara, primary, Bovis, Francesca, additional, Novi, Giovanni, additional, Capobianco, Marco, additional, Lanzillo, Roberta, additional, Frau, Jessica, additional, Repice, Anna Maria, additional, Hakiki, Bahia, additional, Realmuto, Sabrina, additional, Bonavita, Simona, additional, Curti, Erica, additional, Brambilla, Laura, additional, Mataluni, Giorgia, additional, Cavalla, Paola, additional, Di Sapio, Alessia, additional, Signoriello, Elisabetta, additional, Barone, Stefania, additional, Maniscalco, Giorgia T, additional, Maietta, Ilaria, additional, Maraffi, Isabella, additional, Boffa, Giacomo, additional, Malucchi, Simona, additional, Nozzolillo, Agostino, additional, Coghe, Giancarlo, additional, Mechi, Claudia, additional, Salemi, Giuseppe, additional, Gallo, Antonio, additional, Sacco, Rosaria, additional, Cellerino, Maria, additional, Malentacchi, Maria, additional, De Angelis, Marcello, additional, Lorefice, Lorena, additional, Magnani, Eliana, additional, Prestipino, Elio, additional, Sperli, Francesca, additional, Brescia Morra, Vincenzo, additional, Fenu, Giuseppe, additional, Barilaro, Alessandro, additional, Abbadessa, Gianmarco, additional, Signori, Alessio, additional, Granella, Franco, additional, Amato, Maria Pia, additional, Uccelli, Antonio, additional, Gobbi, Claudio, additional, and Sormani, Maria Pia, additional

Published
2019
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12. e-Health and multiple sclerosis: An update

Author

Lavorgna, Luigi, primary, Brigo, Francesco, additional, Moccia, Marcello, additional, Leocani, Letizia, additional, Lanzillo, Roberta, additional, Clerico, Marinella, additional, Abbadessa, Gianmarco, additional, Schmierer, Klaus, additional, Solaro, Claudio, additional, Prosperini, Luca, additional, Tedeschi, Gioacchino, additional, Giovannoni, Gavin, additional, and Bonavita, Simona, additional

Published
2018
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13. Regional changes in thalamic shape and volume are related to cognitive performance in multiple sclerosis.

Author

Bisecco, Alvino, Capuano, Rocco, Caiazzo, Giuseppina, d'Ambrosio, Alessandro, Docimo, Renato, Cirillo, Mario, Russo, Antonio, Altieri, Manuela, Bonavita, Simona, Rocca, Maria A, Filippi, Massimo, Tedeschi, Gioacchino, and Gallo, Antonio

Subjects
MULTIPLE sclerosis, RESPONSE inhibition, COGNITION, NEUROPSYCHOLOGICAL tests
Abstract

Background: The relationship between cognitive performance and regional thalamic atrophy in multiple sclerosis (MS) has been investigated in recent studies. Objective and methods: To further assess this relationship, 118 relapsing-remitting MS patients and 52 healthy controls underwent a neuropsychological assessment and a 3T-MRI (3-Tesla magnetic resonance imaging). Cognitive performances were correlated with thalamic shape changes by using Vertex Analysis. Results: Information processing speed performance correlated with atrophy of frontal/motor-connected thalamic sub-regions. Inhibitory control performance correlated with atrophy of all thalamic sub-regions. Global cognitive status correlated with atrophy of frontal/temporal-connected sub-regions. Conclusions: These findings support the hypothesis that, within the thalamus, the damage of the anterior regions is most relevant for cognitive dysfunction. [ABSTRACT FROM AUTHOR]

Published
2021
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14. Treatment of multiple sclerosis with rituximab: A multicentric Italian–Swiss experience.

Author

Zecca, Chiara, Bovis, Francesca, Novi, Giovanni, Capobianco, Marco, Lanzillo, Roberta, Frau, Jessica, Repice, Anna Maria, Hakiki, Bahia, Realmuto, Sabrina, Bonavita, Simona, Curti, Erica, Brambilla, Laura, Mataluni, Giorgia, Cavalla, Paola, Di Sapio, Alessia, Signoriello, Elisabetta, Barone, Stefania, Maniscalco, Giorgia T, Maietta, Ilaria, and Maraffi, Isabella

Subjects
MULTIPLE sclerosis, B cells, MONOCLONAL antibodies, RITUXIMAB, JOHN Cunningham virus
Abstract

Background: Rituximab, an anti-CD20 monoclonal antibody leading to B lymphocyte depletion, is increasingly used as an off-label treatment option for multiple sclerosis (MS). Objective: To investigate the effectiveness and safety of rituximab in relapsing–remitting (RR) and progressive MS. Methods: This is a multicenter, retrospective study on consecutive MS patients treated off-label with rituximab in 22 Italian and 1 Swiss MS centers. Relapse rate, time to first relapse, Expanded Disability Status Scale (EDSS) progression, incidence of adverse events, and radiological outcomes from 2009 to 2019 were analyzed. Results: A total of 355/451 enrolled subjects had at least one follow-up visit and were included in the outcome analysis. Annualized relapse rate significantly decreases after rituximab initiation versus the pre-rituximab start year in RRMS (from 0.86 to 0.09, p <.0001) and in secondary-progressive (SP) MS (from 0.34 to 0.06, p <.0001) and had a slight decrease in primary-progressive (PP) MS patients (from 0.12 to 0.07, p = 0.45). After 3 years from rituximab start, the proportion of patients with a confirmed EDSS progression was 14.6% in the RRMS group, 24.7% in the SPMS group, and 41.5% in the PPMS group. No major safety concerns arose. Conclusion: Consistently with other observational studies, our data show effectiveness of rituximab in reducing disease activity in patients with MS. [ABSTRACT FROM AUTHOR]

Published
2020
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15. Determinants of therapy switch in multiple sclerosis treatment-naïve patients: A real-life study

Author

Saccà, Francesco, primary, Lanzillo, Roberta, additional, Signori, Alessio, additional, Maniscalco, Giorgia T, additional, Signoriello, Elisabetta, additional, Lo Fermo, Salvatore, additional, Repice, Annamaria, additional, Annovazzi, Pietro, additional, Baroncini, Damiano, additional, Clerico, Marinella, additional, Binello, Eleonora, additional, Cerqua, Raffaella, additional, Mataluni, Giorgia, additional, Bonavita, Simona, additional, Lavorgna, Luigi, additional, Zarbo, Ignazio Roberto, additional, Laroni, Alice, additional, Rossi, Silvia, additional, Pareja Gutierrez, Lorena, additional, La Gioia, Sara, additional, Frigeni, Barbara, additional, Barcella, Valeria, additional, Frau, Jessica, additional, Cocco, Eleonora, additional, Fenu, Giuseppe, additional, Torri Clerici, Valentina, additional, Sartori, Arianna, additional, Rasia, Sarah, additional, Cordioli, Cinzia, additional, Di Sapio, Alessia, additional, Pontecorvo, Simona, additional, Grasso, Roberta, additional, Barrilà, Caterina, additional, Russo, Cinzia Valeria, additional, Esposito, Sabrina, additional, Ippolito, Domenico, additional, Bovis, Francesca, additional, Gallo, Fabio, additional, and Sormani, Maria Pia, additional

Published
2018
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16. Fatigue in multiple sclerosis: The contribution of resting-state functional connectivity reorganization

Author

Bisecco, Alvino, primary, Nardo, Federica Di, additional, Docimo, Renato, additional, Caiazzo, Giuseppina, additional, d’Ambrosio, Alessandro, additional, Bonavita, Simona, additional, Capuano, Rocco, additional, Sinisi, Leonardo, additional, Cirillo, Mario, additional, Esposito, Fabrizio, additional, Tedeschi, Gioacchino, additional, and Gallo, Antonio, additional

Published
2017
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17. Determinants of therapy switch in multiple sclerosis treatment-naïve patients: A real-life study.

Author

Saccà, Francesco, Lanzillo, Roberta, Signori, Alessio, Maniscalco, Giorgia T, Signoriello, Elisabetta, Lo Fermo, Salvatore, Repice, Annamaria, Annovazzi, Pietro, Baroncini, Damiano, Clerico, Marinella, Binello, Eleonora, Cerqua, Raffaella, Mataluni, Giorgia, Bonavita, Simona, Lavorgna, Luigi, Zarbo, Ignazio Roberto, Laroni, Alice, Rossi, Silvia, Pareja Gutierrez, Lorena, and La Gioia, Sara

Subjects
MULTIPLE sclerosis, MULTIPLE sclerosis treatment, DECISION making
Abstract

Background: With many options now available, first therapy choice is challenging in multiple sclerosis (MS) and depends mainly on neurologist and patient preferences. Objectives: To identify prognostic factors for early switch after first therapy choice. Methods: Newly diagnosed relapsing–remitting MS patients from 24 Italian centers were included. We evaluated the association of baseline demographics, clinical, and magnetic resonance imaging (MRI) data to the switch probability for lack of efficacy or intolerance/safety with a multivariate Cox analysis and estimated switch rates by competing risks models. Results: We enrolled 3025 patients. The overall switch frequency was 48% after 3 years. Switch risk for lack of efficacy was lower with fingolimod (hazard ratio (HR) = 0.50; p = 0.009), natalizumab (HR = 0.13; p < 0.001), dimethyl-fumarate (HR = 0.60; p = 0.037), teriflunomide (HR = 0.21; p = 0.031) as compared to interferons. Younger age (HR = 0.96; p < 0.001), diagnosis delay (HR = 1.23; p = 0.021), higher baseline Expanded Disability Status Scale (HR = 1.17; p = 0.001), and spinal cord lesions (HR = 1.46; p = 0.001) were independently associated with higher inefficacy switch rates. We found lower switch for intolerance/safety with glatiramer acetate (HR = 0.61; p = 0.001), fingolimod (HR = 0.35; p = 0.002), and dimethyl-fumarate (HR = 0.57; p = 0.022) as compared to interferons, while it increased with natalizumab (HR = 1.43; p = 0.022). Comorbidities were associated with intolerance switch (HR = 1.28; p = 0.047). Conclusion: Several factors are associated with higher switch risk in patients starting a first-line therapy and could be integrated in the decision-making process of first treatment choice. [ABSTRACT FROM AUTHOR]

Published
2019
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18. Fatigue in multiple sclerosis: The contribution of resting-state functional connectivity reorganization.

Author

Bisecco, Alvino, Nardo, Federica Di, Docimo, Renato, Caiazzo, Giuseppina, d’Ambrosio, Alessandro, Bonavita, Simona, Capuano, Rocco, Sinisi, Leonardo, Cirillo, Mario, Esposito, Fabrizio, Tedeschi, Gioacchino, and Gallo, Antonio

Subjects
MULTIPLE sclerosis, DEMYELINATION, FATIGUE (Physiology), SENSORIMOTOR integration, SENSORY processing disorder
Abstract

Objectives: To investigate resting-state functional connectivity (RS-FC) of the default-mode network (DMN) and of sensorimotor network (SMN) network in relapsing remitting (RR) multiple sclerosis (MS) patients with fatigue (F) and without fatigue(NF). Methods: In all, 59 RRMS patients and 29 healthy controls (HC) underwent magnetic resonance imaging (MRI) protocol including resting-state fMRI (RS-fMRI). Functional connectivity of the DMN and SMN was evaluated by independent component analysis (ICA). A linear regression analysis was performed to explore whether fatigue was mainly driven by changes observed in the DMN or in the SMN. Regional gray matter atrophy was assessed by voxel-based morphometry (VBM). Results: Compared to HC, F-MS patients showed a stronger RS-FC in the posterior cingulate cortex (PCC) and a reduced RS-FC in the anterior cingulated cortex (ACC) of the DMN. F-MS patients, compared to NF-MS patients, revealed (1) an increased RS-FC in the PCC and a reduced RS-FC in the ACC of the DMN and (2) an increased RS-FC in the primary motor cortex and in the supplementary motor cortex of the SMN. The regression analysis suggested that fatigue is mainly driven by RS-FC changes of the DMN. Conclusions: Fatigue in RRMS is mainly associated to a functional rearrangement of non-motor RS networks. [ABSTRACT FROM AUTHOR]

Published
2018
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19. Fatigue in multiple sclerosis: The contribution of occult white matter damage

Author

Bisecco, Alvino, primary, Caiazzo, Giuseppina, additional, d’Ambrosio, Alessandro, additional, Sacco, Rosaria, additional, Bonavita, Simona, additional, Docimo, Renato, additional, Cirillo, Mario, additional, Pagani, Elisabetta, additional, Filippi, Massimo, additional, Esposito, Fabrizio, additional, Tedeschi, Gioacchino, additional, and Gallo, Antonio, additional

Published
2016
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20. Distributed changes in default-mode resting-state connectivity in multiple sclerosis

Author

Bonavita, Simona, primary, Gallo, Antonio, additional, Sacco, Rosaria, additional, Corte, Marida Della, additional, Bisecco, Alvino, additional, Docimo, Renato, additional, Lavorgna, Luigi, additional, Corbo, Daniele, additional, Costanzo, Alfonso Di, additional, Tortora, Fabio, additional, Cirillo, Mario, additional, Esposito, Fabrizio, additional, and Tedeschi, Gioacchino, additional

Published
2011
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21. Fatigue in multiple sclerosis: The contribution of resting-state functional connectivity reorganization

Author

Renato Docimo, Alessandro d’Ambrosio, Antonio Gallo, Giuseppina Caiazzo, Leonardo Sinisi, Mario Cirillo, Simona Bonavita, Alvino Bisecco, Gioacchino Tedeschi, Federica Di Nardo, Rocco Capuano, Fabrizio Esposito, Bisecco, Alvino, Nardo, Federica Di, Docimo, Renato, Caiazzo, Giuseppina, D'Ambrosio, Alessandro, Bonavita, Simona, Capuano, Rocco, Sinisi, Leonardo, Cirillo, Mario, Esposito, Fabrizio, Tedeschi, Gioacchino, and Gallo, Antonio

Subjects
Adult, Male, 0301 basic medicine, Multiple Sclerosis, Rest, sensorimotor network, Gyrus Cinguli, default mode network, 03 medical and health sciences, 0302 clinical medicine, Neural Pathways, Image Processing, Computer-Assisted, medicine, Humans, Multiple sclerosi, resting state, Fatigue, Default mode network, Brain Mapping, fatigue, functional magnetic resonance imaging, Multiple sclerosis, Neurology, Neurology (clinical), Resting state fMRI, medicine.diagnostic_test, business.industry, Functional connectivity, medicine.disease, Magnetic Resonance Imaging, 030104 developmental biology, Relapsing remitting, Sensorimotor network, Female, Nerve Net, Functional magnetic resonance imaging, business, Neuroscience, 030217 neurology & neurosurgery
Abstract

Objectives: To investigate resting-state functional connectivity (RS-FC) of the default-mode network (DMN) and of sensorimotor network (SMN) network in relapsing remitting (RR) multiple sclerosis (MS) patients with fatigue (F) and without fatigue(NF). Methods: In all, 59 RRMS patients and 29 healthy controls (HC) underwent magnetic resonance imaging (MRI) protocol including resting-state fMRI (RS-fMRI). Functional connectivity of the DMN and SMN was evaluated by independent component analysis (ICA). A linear regression analysis was performed to explore whether fatigue was mainly driven by changes observed in the DMN or in the SMN. Regional gray matter atrophy was assessed by voxel-based morphometry (VBM). Results: Compared to HC, F-MS patients showed a stronger RS-FC in the posterior cingulate cortex (PCC) and a reduced RS-FC in the anterior cingulated cortex (ACC) of the DMN. F-MS patients, compared to NF-MS patients, revealed (1) an increased RS-FC in the PCC and a reduced RS-FC in the ACC of the DMN and (2) an increased RS-FC in the primary motor cortex and in the supplementary motor cortex of the SMN. The regression analysis suggested that fatigue is mainly driven by RS-FC changes of the DMN. Conclusions: Fatigue in RRMS is mainly associated to a functional rearrangement of non-motor RS networks.

Published
2017

22. Distributed changes in default-mode resting-state connectivity in multiple sclerosis

Author

Marida Della Corte, Mario Cirillo, Simona Bonavita, Gioacchino Tedeschi, Renato Docimo, Luigi Lavorgna, Fabrizio Esposito, Antonio Gallo, Alvino Bisecco, Alfonso Di Costanzo, Rosaria Sacco, Daniele Corbo, Fabio Tortora, Bonavita, Simona, Gallo, Antonio, Sacco, R, DELLA CORTE, M, Bisecco, Alvino, Docimo, R, Lavorgna, L, Corbo, D, DI COSTANZO, A, Tortora, Fabio, Cirillo, Mario, Esposito, F, and Tedeschi, Gioacchino

Subjects
Adult, Male, medicine.medical_specialty, Neuropsychological Tests, Audiology, computer.software_genre, Severity of Illness Index, Brain mapping, Multiple Sclerosis, Relapsing-Remitting, Atrophy, Voxel, Image Processing, Computer-Assisted, medicine, Humans, Anterior cingulate cortex, Brain Mapping, Resting state fMRI, medicine.diagnostic_test, Multiple sclerosis, Neuropsychology, Brain, Magnetic resonance imaging, Middle Aged, medicine.disease, Magnetic Resonance Imaging, medicine.anatomical_structure, Neurology, Female, Neurology (clinical), Nerve Net, Cognition Disorders, Psychology, human activities, Neuroscience, computer
Abstract

Background: The default-mode network (DMN) has been increasingly recognized as relevant to cognitive status. Objectives: To explore DMN changes in patients with relapsing–remitting (RR) multiple sclerosis (MS) and to relate these to the cognitive status. Methods: Eighteen cognitively impaired (CI) and eighteen cognitively preserved (CP) RRMS patients and eighteen healthy controls (HCs), matched for age, sex and education, underwent neuropsychological evaluation and anatomical and resting-state functional MRI (rs-fMRI). DMN functional connectivity was evaluated from rs-fMRI data via independent component analysis. T2 lesion load (LL) was computed by a semi-automatic method and global and local atrophy was estimated by SIENAX and SPM8 voxel-based morphometry analyses from 3D-T1 images. Results: When the whole group of RRMS patients was compared with HCs, DMN connectivity was significantly weaker in the anterior cingulate cortex, whereas it was significantly weaker in the core but stronger at the periphery of the posterior cingulate cortex. These findings were more evident in CP than CI patients. Observed DMN changes did not correlate with global atrophy or T2-LL, but were locally associated with regional grey matter loss. Conclusion: Relapsing–remitting multiple sclerosis patients show a consistent dysfunction of DMN at the level of the anterior node. DMN distribution changes in the posterior node may reflect a possible compensatory effect on cognitive performance.

Published
2011

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