1. Distinct pattern of lesion distribution in multiple sclerosis is associated with different circulating T-helper and helper-like innate lymphoid cell subsets
- Author
-
Uta Hanning, Anita Posevitz-Fejfar, Sven G. Meuth, Andreas Schulte-Mecklenbeck, Catharina Korsukewitz, Nicholas Schwab, Heinz Wiendl, Luisa Klotz, and Catharina C. Gross
- Subjects
Adult ,Male ,0301 basic medicine ,Pathology ,medicine.medical_specialty ,Antigen presentation ,Biology ,Immunophenotyping ,Lesion ,Disability Evaluation ,Young Adult ,03 medical and health sciences ,Multiple Sclerosis, Relapsing-Remitting ,0302 clinical medicine ,Immune system ,medicine ,Humans ,Lymphocytes ,Aged ,Interleukins ,Multiple sclerosis ,Interleukin-17 ,Innate lymphoid cell ,Brain ,Granulocyte-Macrophage Colony-Stimulating Factor ,Interleukin ,Middle Aged ,Th1 Cells ,Flow Cytometry ,medicine.disease ,Magnetic Resonance Imaging ,Immunity, Innate ,Phenotype ,030104 developmental biology ,Spinal Cord ,Neurology ,Case-Control Studies ,Immunology ,Th17 Cells ,Female ,Neurology (clinical) ,Interleukin 17 ,medicine.symptom ,Biomarkers ,030217 neurology & neurosurgery - Abstract
Background: Distinct lesion topography in relapsing-remitting multiple sclerosis (RRMS) might be due to different antigen presentation and/or trafficking routes of immune cells into the central nervous system (CNS). Objective: To investigate whether distinct lesion patterns in multiple sclerosis (MS) might be associated with a predominance of distinct circulating T-helper cell subset as well as their innate counterparts. Methods: Flow cytometric analysis of lymphocytes derived from the peripheral blood of patients with exclusively cerebral (n = 20) or predominantly spinal (n = 12) disease manifestation. Results: Patients with exclusively cerebral or preferential spinal lesion manifestation were associated with increased proportions of circulating granulocyte-macrophage colony-stimulating factor (GM-CSF) producing TH1 cells or interleukin (IL)-17-producing TH17 cells, respectively. In contrast, proportions of peripheral IL-17/IL-22-producing lymphoid tissue inducer (LTi), the innate counterpart of TH17 cells, were enhanced in RRMS patients with exclusively cerebral lesion topography. Conclusions: Distinct T-helper and T-helper-like innate lymphoid cell (ILC) subsets are associated with different lesion topography in RRMS.
- Published
- 2016