1. Characterizing 1-year development of cervical cord atrophy across different MS phenotypes
- Author
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Paola Valsasina, Claudio Gobbi, Chiara Zecca, Alex Rovira, Jaume Sastre-Garriga, Hugh Kearney, Marios Yiannakas, Lucy Matthews, Jacqueline Palace, Antonio Gallo, Alvino Bisecco, Achim Gass, Philipp Eisele, Massimo Filippi, Maria A Rocca, Frederik Barkhof, Olga Ciccarelli, Nicola De Stefano, Christian Enzinger, Claudio Gasperini, Ludwig Kappos, Hugo Vrenken, Tarek Yousry, Anatomy and neurosciences, Radiology and nuclear medicine, Amsterdam Neuroscience - Brain Imaging, Amsterdam Neuroscience - Neuroinfection & -inflammation, CCA - Cancer Treatment and quality of life, CCA - Imaging and biomarkers, Valsasina, P., Gobbi, C., Zecca, C., Rovira, A., Sastre-Garriga, J., Kearney, H., Yiannakas, M., Matthews, L., Palace, J., Gallo, A., Bisecco, A., Gass, A., Eisele, P., Filippi, M., Rocca, M. A., Barkhof, F., Ciccarelli, O., De Stefano, N., Enzinger, C., Gasperini, C., Kappos, L., Vrenken, H., and Yousry, T.
- Subjects
Pathology ,medicine.medical_specialty ,Cord ,Multiple Sclerosis ,Cervical cord ,computer.software_genre ,Multiple sclerosis ,Atrophy ,Multiple Sclerosis, Relapsing-Remitting ,Voxel ,medicine ,Distribution (pharmacology) ,Humans ,Multiple sclerosi ,business.industry ,spinal cord ,Brain ,Cervical Cord ,Spinal cord ,medicine.disease ,Phenotype ,Magnetic Resonance Imaging ,medicine.anatomical_structure ,disability ,Neurology ,Spinal Cord ,voxel-wise analysis ,Disease Progression ,Neurology (clinical) ,business ,computer ,MRI ,Demyelinating Diseases - Abstract
Background: Spatio-temporal evolution of cord atrophy in multiple sclerosis (MS) has not been investigated yet. Objective: To evaluate voxel-wise distribution and 1-year changes of cervical cord atrophy in a multicentre MS cohort. Methods: Baseline and 1-year 3D T1-weighted cervical cord scans and clinical evaluations of 54 healthy controls (HC) and 113 MS patients (14 clinically isolated syndromes (CIS), 77 relapsing-remitting (RR), 22 progressive (P)) were used to investigate voxel-wise cord volume loss in patients versus HC, 1-year volume changes and clinical correlations (SPM12). Results: MS patients exhibited baseline cord atrophy versus HC at anterior and posterior/lateral C1/C2 and C4–C6 ( p < 0.05, corrected). While CIS patients showed baseline volume increase at C4 versus HC ( p < 0.001, uncorrected), RRMS exhibited posterior/lateral C1/C2 atrophy versus CIS, and PMS showed widespread cord atrophy versus RRMS ( p < 0.05, corrected). At 1 year, 13 patients had clinically worsened. Cord atrophy progressed in MS, driven by RRMS, at posterior/lateral C2 and C3–C6 ( p < 0.05, corrected). CIS patients showed no volume changes, while PMS showed circumscribed atrophy progression. Baseline cord atrophy at posterior/lateral C1/C2 and C3–C6 correlated with concomitant and 1-year disability ( r = −0.40/–0.62, p < 0.05, corrected). Conclusions: Voxel-wise analysis characterized spinal cord neurodegeneration over 1 year across MS phenotypes and helped to explain baseline and 1-year disability.
- Published
- 2022