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Your search keyword '"Henderson, I R"' showing total 3 results
Start Over Author "Henderson, I R" Journal mucosal immunology
3 results on '"Henderson, I R"'

1. CD103+CD11b+ mucosal classical dendritic cells initiate long-term switched antibody responses to flagellin

Author

Flores-Langarica, A, primary, Müller Luda, K, additional, Persson, E K, additional, Cook, C N, additional, Bobat, S, additional, Marshall, J L, additional, Dahlgren, M W, additional, Hägerbrand, K, additional, Toellner, K M, additional, Goodall, M D, additional, Withers, D R, additional, Henderson, I R, additional, Johansson Lindbom, B, additional, Cunningham, A F, additional, and Agace, W W, additional

Published
2018
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2. CD103+CD11b+mucosal classical dendritic cells initiate long-term switched antibody responses to flagellin

Author

Flores-Langarica, A, Müller Luda, K, Persson, E K, Cook, C N, Bobat, S, Marshall, J L, Dahlgren, M W, Hägerbrand, K, Toellner, K M, Goodall, M D, Withers, D R, Henderson, I R, Johansson Lindbom, B, Cunningham, A F, and Agace, W W

Abstract

Antibody responses induced at mucosal and nonmucosal sites demonstrate a significant level of autonomy. Here, we demonstrate a key role for mucosal interferon regulatory factor-4 (IRF4)-dependent CD103+CD11b+(DP), classical dendritic cells (cDCs) in the induction of T-dependent immunoglobulin G (IgG) and immunoglobulin A (IgA) responses in the mesenteric lymph node (MLN) following systemic immunization with soluble flagellin (sFliC). In contrast, IRF8-dependent CD103+CD11b−(SP) are not required for these responses. The lack of this response correlated with a complete absence of sFliC-specific plasma cells in the MLN, small intestinal lamina propria, and surprisingly also the bone marrow (BM). Many sFliC-specific plasma cells accumulating in the BM of immunized wild-type mice expressed α4β7+, suggesting a mucosal origin. Collectively, these results suggest that mucosal DP cDC contribute to the generation of the sFliC-specific plasma cell pool in the BM and thus serve as a bridge linking the mucosal and systemic immune system.

Published
2018
Full Text
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3. CD103 + CD11b + mucosal classical dendritic cells initiate long-term switched antibody responses to flagellin.

Author

Flores-Langarica A, Müller Luda K, Persson EK, Cook CN, Bobat S, Marshall JL, Dahlgren MW, Hägerbrand K, Toellner KM, Goodall MD, Withers DR, Henderson IR, Johansson Lindbom B, Cunningham AF, and Agace WW

Subjects
Animals, Antigens, CD metabolism, CD11b Antigen metabolism, Cells, Cultured, Flagellin immunology, Immunity, Humoral, Immunoglobulin A metabolism, Immunoglobulin Class Switching, Immunoglobulin G metabolism, Integrin alpha Chains metabolism, Integrin alpha4 metabolism, Integrin beta Chains metabolism, Interferon Regulatory Factors genetics, Mice, Mice, Inbred C57BL, Mice, Knockout, Dendritic Cells immunology, Interferon Regulatory Factors metabolism, Lymph Nodes immunology, Mucous Membrane immunology, Plasma Cells immunology
Abstract

Antibody responses induced at mucosal and nonmucosal sites demonstrate a significant level of autonomy. Here, we demonstrate a key role for mucosal interferon regulatory factor-4 (IRF4)-dependent CD103 + CD11b + (DP), classical dendritic cells (cDCs) in the induction of T-dependent immunoglobulin G (IgG) and immunoglobulin A (IgA) responses in the mesenteric lymph node (MLN) following systemic immunization with soluble flagellin (sFliC). In contrast, IRF8-dependent CD103 + CD11b - (SP) are not required for these responses. The lack of this response correlated with a complete absence of sFliC-specific plasma cells in the MLN, small intestinal lamina propria, and surprisingly also the bone marrow (BM). Many sFliC-specific plasma cells accumulating in the BM of immunized wild-type mice expressed α 4 β 7 + , suggesting a mucosal origin. Collectively, these results suggest that mucosal DP cDC contribute to the generation of the sFliC-specific plasma cell pool in the BM and thus serve as a bridge linking the mucosal and systemic immune system.

Published
2018
Full Text
View/download PDF

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