1. Addiction in Parkinson's disease: impact of subthalamic nucleus deep brain stimulation.
- Author
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Witjas T, Baunez C, Henry JM, Delfini M, Regis J, Cherif AA, Peragut JC, and Azulay JP
- Subjects
- Adult, Behavior, Addictive complications, Clinical Protocols, Humans, Male, Middle Aged, Parkinson Disease complications, Behavior, Addictive therapy, Deep Brain Stimulation methods, Parkinson Disease therapy, Subthalamic Nucleus radiation effects
- Abstract
In Parkinson's disease, dopamine dysregulation syndrome (DDS) is characterized by severe dopamine addiction and behavioral disorders such as manic psychosis, hypersexuality, pathological gambling, and mood swings. Here, we describe the case of 2 young parkinsonian patients suffering from disabling motor fluctuations and dyskinesia associated with severe DDS. In addition to alleviating the motor disability in both patients, subthalamic nucleus (STN) deep brain stimulation greatly reduced the behavioral disorders as well as completely abolished the addiction to dopaminergic treatment. Dopaminergic addiction in patients with Parkinson's disease, therefore, does not constitute an obstacle to high-frequency STN stimulation, and this treatment may even cure the addiction., (Copyright 2005 Movement Disorder Society)
- Published
- 2005
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