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13 results on '"Tessitore, Alessandro"'

2. Memory Phenotypes In Early, De Novo Parkinson's Disease Patients with Mild Cognitive Impairment

Author

Siciliano, Mattia, primary, De Micco, Rosa, additional, Russo, Andrea Gerardo, additional, Esposito, Fabrizio, additional, Sant'Elia, Valeria, additional, Ricciardi, Lucia, additional, Morgante, Francesca, additional, Russo, Antonio, additional, Goldman, Jennifer G., additional, Chiorri, Carlo, additional, Tedeschi, Gioacchino, additional, Trojano, Luigi, additional, and Tessitore, Alessandro, additional

Published
2023
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4. Development and Validation of Automated Magnetic Resonance Parkinsonism Index 2.0 to Distinguish Progressive Supranuclear Palsy‐Parkinsonism From Parkinson's Disease

Author

Quattrone, Andrea, primary, Bianco, Maria G., additional, Antonini, Angelo, additional, Vaillancourt, David E., additional, Seppi, Klaus, additional, Ceravolo, Roberto, additional, Strafella, Antonio P., additional, Tedeschi, Gioacchino, additional, Tessitore, Alessandro, additional, Cilia, Roberto, additional, Morelli, Maurizio, additional, Nigro, Salvatore, additional, Vescio, Basilio, additional, Arcuri, Pier Paolo, additional, De Micco, Rosa, additional, Cirillo, Mario, additional, Weis, Luca, additional, Fiorenzato, Eleonora, additional, Biundo, Roberta, additional, Burciu, Roxana G., additional, Krismer, Florian, additional, McFarland, Nikolaus R., additional, Mueller, Christoph, additional, Gizewski, Elke R., additional, Cosottini, Mirco, additional, Del Prete, Eleonora, additional, Mazzucchi, Sonia, additional, and Quattrone, Aldo, additional

Published
2022
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7. Skin Biopsy May Help to Distinguish Multiple System Atrophy–Parkinsonism from Parkinson's Disease With Orthostatic Hypotension

Author

Donadio, Vincenzo, primary, Incensi, Alex, additional, Rizzo, Giovanni, additional, De Micco, Rosa, additional, Tessitore, Alessandro, additional, Devigili, Grazia, additional, Del Sorbo, Francesca, additional, Bonvegna, Salvatore, additional, Infante, Rossella, additional, Magnani, Martina, additional, Zenesini, Corrado, additional, Vignatelli, Luca, additional, Cilia, Roberto, additional, Eleopra, Roberto, additional, Tedeschi, Gioacchino, additional, and Liguori, Rocco, additional

Published
2020
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9. Connectivity Correlates of Anxiety Symptoms in Drug‐Naive Parkinson's Disease Patients.

Author

De Micco, Rosa, Satolli, Sara, Siciliano, Mattia, Nardo, Federica, Caiazzo, Giuseppina, Russo, Antonio, Giordano, Alfonso, Esposito, Fabrizio, Tedeschi, Gioacchino, and Tessitore, Alessandro

Abstract

Background: Anxiety symptoms are common in Parkinson's disease (PD). A link between anxiety and cognitive impairment in PD has been demonstrated. Objectives: Using resting‐state functional magnetic resonance imaging, we investigated intrinsic brain network connectivity correlates of anxiety symptoms in a cohort of drug‐naive, cognitively unimpaired patients with PD. Methods: The intrinsic functional brain connectivity of 25 drug‐naive, cognitively unimpaired PD patients with anxiety, 25 without anxiety, and 20 matched healthy controls was compared. All patients underwent a detailed behavioral and neuropsychological evaluation. Anxiety presence and severity were assessed using the Parkinson's Disease Anxiety Scale. Single‐subject and group‐level independent component analyses were used to investigate functional connectivity differences within and between the major resting‐state networks. Results: Decreased connectivity within the default‐mode and sensorimotor networks (SMN), increased connectivity within the executive‐control network (ECN), and divergent connectivity measures within salience and frontoparietal networks (SN and FPN) were detected in PD patients with anxiety compared with those without anxiety. Moreover, patients with anxiety showed a disrupted inter‐network connectivity between SN and SMN, ECN, and FPN. Anxiety severity was correlated with functional abnormalities within these networks. Conclusions: Our findings demonstrated that an abnormal intrinsic connectivity within and between the most reported large‐scale networks may represent a potential neural correlate of anxiety symptoms in drug‐naive PD patients even in the absence of clinically relevant cognitive impairment. We hypothesize that these specific cognitive and limbic network architecture changes may represent a potential biomarker of treatment response in clinical trials. © 2020 International Parkinson and Movement Disorder Society [ABSTRACT FROM AUTHOR]

Published
2021
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12. The role of high-field magnetic resonance imaging in parkinsonian disorders: Pushing the boundaries forward.

Author

Lehericy, Stéphane, Vaillancourt, David E., Seppi, Klaus, Monchi, Oury, Rektorova, Irena, Antonini, Angelo, McKeown, Martin J., Masellis, Mario, Berg, Daniela, Rowe, James B., Lewis, Simon J. G., Williams ‐ Gray, Caroline H., Tessitore, Alessandro, Siebner, Hartwig R., Lehericy, Stéphane, Williams-Gray, Caroline H, and International Parkinson and Movement Disorder Society (IPMDS)-Neuroimaging Study Group

Subjects
MAGNETIC resonance imaging, RESEARCH funding, THREE-dimensional imaging, PARKINSONIAN disorders
Abstract

Historically, magnetic resonance imaging (MRI) has contributed little to the study of Parkinson's disease (PD), but modern MRI approaches have unveiled several complementary markers that are useful for research and clinical applications. Iron- and neuromelanin-sensitive MRI detect qualitative changes in the substantia nigra. Quantitative MRI markers can be derived from diffusion weighted and iron-sensitive imaging or volumetry. Functional brain alterations at rest or during task performance have been captured with functional and arterial spin labeling perfusion MRI. These markers are useful for the diagnosis of PD and atypical parkinsonism, to track disease progression from the premotor stages of these diseases and to better understand the neurobiological basis of clinical deficits. A current research goal using MRI is to generate time-dependent models of the evolution of PD biomarkers that can help understand neurodegeneration and provide reliable markers for therapeutic trials. This article reviews recent advances in MRI biomarker research at high-field (3T) and ultra high field-imaging (7T) in PD and atypical parkinsonism. © 2017 The Authors. Movement Disorders published by Wiley Periodicals, Inc. on behalf of International Parkinson and Movement Disorder Society. [ABSTRACT FROM AUTHOR]

Published
2017
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