Search

Your search keyword '"Jardim Laura"' showing total 11 results
Start Over Author "Jardim Laura" Journal movement disorders
11 results on '"Jardim Laura"'

2. Autosomal Recessive Cerebellar Ataxias in South America: A Multicenter Study of 1338 Patients

Author

Gama, Maria Thereza D., primary, Braga‐Neto, Pedro, additional, Rangel, Deborah M., additional, Godeiro, Clécio, additional, Alencar, Rodrigo, additional, Embiruçu, Emília K., additional, Cornejo‐Olivas, Mario, additional, Sarapura‐Castro, Elison, additional, Saffie Awad, Paula, additional, Muñoz Chesta, Daniela, additional, Kauffman, Marcelo, additional, Rodriguez‐Quiroga, Sergio, additional, Jardim, Laura B., additional, da Graça, Felipe F., additional, França, Marcondes C., additional, Tomaselli, Pedro J., additional, Marques, Wilson, additional, Teive, Helio A.G., additional, Barsottini, Orlando G.P., additional, Pedroso, José Luiz, additional, and Synofzik, Matthis, additional

Published
2022
Full Text
View/download PDF

3. Progression of Clinical and Eye Movement Markers in Preataxic Carriers of Machado‐Joseph Disease.

Author

de Oliveira, Camila Maria, Leotti, Vanessa Bielefeldt, Cappelli, Amanda Henz, Rocha, Anastacia Guimarães, Ecco, Gabriela, Bolzan, Gabriela, Kersting, Nathalia, Saraiva‐Pereira, Maria‐Luiza, and Jardim, Laura Bannach

Abstract

Background: Little is known about preclinical stages of Machado‐Joseph disease, a polyglutamine disorder characterized by progressive adult‐onset ataxia. Objective: We aimed to describe the longitudinal progression of clinical and oculomotor variables in the preataxic phase of disease. Methods: Carriers and noncarriers were assessed at three visits. Preataxic carriers (Scale for Assessment and Rating of Ataxia score < 3) expected to start ataxia in ≤4 years were considered near onset (PAN). Progressions of ataxic and preataxic carriers, considering status at the end of the study, were described according to the start (or its prediction) of gait ataxia (TimeToAfterOnset) and according to the study time. Results: A total of 35 ataxics, 38 preataxics, and 22 noncarriers were included. The "TimeToAfterOnset" timeline showed that Neurological Examination Scale for Spinocerebellar Ataxias (NESSCA; effect size, 0.09), Inventory of Non‐Ataxia Symptoms (INAS0.07), and the vestibulo‐ocular reflex gain (0.12) progressed in preataxic carriers, and that most slopes accelerate in PAN, turning similar to those of ataxics. In the study time, NESSCA (1.36) and vertical pursuit gain (1.17) significantly worsened in PAN, and 6 of 11 PANs converted to ataxia. For a clinical trial with 80% power and 2‐year duration, 57 PANs are needed in each study arm to detect a 50% reduction in the conversion rate. Conclusions: NESSCA, INAS, vestibulo‐ocular reflex, and vertical pursuit gains significantly worsened in the preataxic phase. The "TimeToAfterOnset" timeline unveiled that slopes of most variables are small in preataxics but increase and reach the ataxic slopes from 4 years before the onset of ataxia. For future trials in preataxic carriers, we recommend recruiting PANs and using the conversion rate as the primary outcome. © 2022 International Parkinson and Movement Disorder Society. [ABSTRACT FROM AUTHOR]

Published
2023
Full Text
View/download PDF

4. A Randomized, Phase 2 Clinical Trial of Lithium Carbonate in Machado-Joseph Disease

Author

Saute, Jonas Alex Morales, de Castilhos, Raphael Machado, Monte, Thais Lampert, Schumacher-Schuh, Artur Francisco, Donis, Karina Carvalho, DʼÁvila, Rui, Souza, Gabriele Nunes, Russo, Aline Dutra, Furtado, Gabriel Vasata, Gheno, Tailise Conte, de Souza, Diogo Onofre Gomes, Portela, Luis Valmor Cruz, Saraiva-Pereira, Maria-Luiza, Camey, Suzi Alvez, Torman, Vanessa Bielefeld Leotti, de Mello Rieder, Carlos Roberto, and Jardim, Laura Bannach

Published
2014
Full Text
View/download PDF

7. Pre‐ataxic Changes of Clinical Scales and Eye Movement in Machado–Joseph Disease: BIGPRO Study

Author

Oliveira, Camila Maria, primary, Leotti, Vanessa Bielefeldt, additional, Bolzan, Gabriela, additional, Cappelli, Amanda Henz, additional, Rocha, Anastacia Guimarães, additional, Ecco, Gabriela, additional, Kersting, Nathalia, additional, Rieck, Mariana, additional, Martins, Ana Carolina, additional, Sena, Lucas Schenatto, additional, Saraiva‐Pereira, Maria‐Luiza, additional, and Jardim, Laura Bannach, additional

Published
2021
Full Text
View/download PDF

10. Serum insulin-like system alterations in patients with spinocerebellar ataxia type 3

Author

Saute, Jonas Alex Morales, primary, da Silva, Andrew Chaves Feitosa, additional, Muller, Alexandre Pastoris, additional, Hansel, Gisele, additional, de Mello, Alexandre Silva, additional, Maeda, Fábio, additional, Vedolin, Leonardo, additional, Saraiva-Pereira, Maria Luiza, additional, Souza, Diogo Onofre, additional, Arpa, Javier, additional, Torres-Aleman, Ignacio, additional, Portela, Luis Valmor Cruz, additional, and Jardim, Laura Bannach, additional

Published
2010
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results