1. Clinicopathological study in progressive supranuclear palsy with pedunculopontine stimulation.
- Author
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Hazrati, Lili-Naz, Wong, Janice C., Hamani, Clement, Lozano, Andres M., Poon, Yu-Yan, Dostrovsky, Jonathan O., Hutchison, William D., Zadikoff, Cindy, and Moro, Elena
- Abstract
Background: Pedunculopontine nucleus (PPN) DBS has emerged as a potential intervention for patients with gait and balance disorders. However, targeting this nucleus can be challenging. We report on the first neuropathological analyses after PPN-DBS surgery in advanced progressive supranuclear palsy (PSP). Methods: Two patients with PSP underwent unilateral PPN-DBS surgery and were clinically followed to autopsy. Both patients underwent postmortem neuropathological analysis, including choline acetyltransferase immunohistochemistry, to ascertain PPN boundaries and electrode location. Results: Both patients experienced partial improvement in some motor and nonmotor domains postintervention, but died shortly of other complications. Postmortem neuropathological analysis of each patient confirmed the electrode in a region of cholinergic neuronal loss corresponding to the PPN. Conclusions: We provide histopathological evidence for the validity of our stereotactic approach to target the PPN and correlate electrode location with clinical outcomes. © 2012 Movement Disorder Society [ABSTRACT FROM AUTHOR]
- Published
- 2012
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