1. Determination of Cotinine in Urine and Wastewaters by High Performance Liquid Chromatography Coupled with Tandem Mass-Spectrometric Detection
- Author
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Andrey V. Pirogov, V. V. Rozhanets, Oleg A. Shpigun, Mongjoo Jang, A. P. Jaricov, V. I. Dobrovolskiy, A. E. Nosyrev, J. V. Abramova, A. A. Priadka, A. A. Stakheev, and A. A. Maksimova
- Subjects
Detection limit ,Chromatography ,Tandem ,010401 analytical chemistry ,Extraction (chemistry) ,General Chemistry ,Urine ,030226 pharmacology & pharmacy ,01 natural sciences ,High-performance liquid chromatography ,Mass spectrometric ,Quantitative determination ,0104 chemical sciences ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,chemistry ,Cotinine - Abstract
A technique of extracting cotinine in urine and wastewaters, followed by its quantitative determination, using high performance liquid chromatography combined with tandem mass-spectrometric detection is presented. The method is characterized by low detection limits and high levels of efficiency and sensitivity. The optimal conditions for the solid-phase extraction of cotinine from urine and wastewaters are found. This technique makes it possible to reliably estimate the content of cotinine in the urine of active and passive smokers and in wastewaters.
- Published
- 2018
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