1. Will the Bacteria Survive in the CeO 2 Nanozyme-H 2 O 2 System?
- Author
-
Zhu W, Wang L, Li Q, Jiao L, Yu X, Gao X, Qiu H, Zhang Z, and Bing W
- Subjects
- Anti-Bacterial Agents pharmacology, Antioxidants pharmacology, Bacteria metabolism, Oxidation-Reduction drug effects, Peroxidase metabolism, Reactive Oxygen Species metabolism, Bacteria drug effects, Cerium pharmacology, Hydrogen Peroxide pharmacology, Nanoparticles chemistry, Nanostructures chemistry
- Abstract
As one of the nanostructures with enzyme-like activity, nanozymes have recently attracted extensive attention for their biomedical applications, especially for bacterial disinfection treatment. Nanozymes with high peroxidase activity are considered to be excellent candidates for building bacterial disinfection systems (nanozyme-H
2 O2 ), in which the nanozyme will promote the generation of ROS to kill bacteria based on the decomposition of H2 O2 . According to this criterion, a cerium oxide nanoparticle (Nanoceria, CeO2 , a classical nanozyme with high peroxidase activity)-based nanozyme-H2 O2 system would be very efficient for bacterial disinfection. However, CeO2 is a nanozyme with multiple enzyme-like activities. In addition to high peroxidase activity, CeO2 nanozymes also possess high superoxide dismutase activity and antioxidant activity, which can act as a ROS scavenger. Considering the fact that CeO2 nanozymes have both the activity to promote ROS production and the opposite activity for ROS scavenging, it is worth exploring which activity will play the dominating role in the CeO2 -H2 O2 system, as well as whether it will protect bacteria or produce an antibacterial effect. In this work, we focused on this discussion to unveil the role of CeO2 in the CeO2 -H2 O2 system, so that it can provide valuable knowledge for the design of a nanozyme-H2 O2 -based antibacterial system.- Published
- 2021
- Full Text
- View/download PDF