1. Functional Magnetic Mesoporous Silica Microparticles Capped with an Azo-Derivative: A Promising Colon Drug Delivery Device.
- Author
-
Teruel, Adrián H., Coll, Carmen, Costero, Ana M., Ferri, Daniel, Parra, Margarita, Gaviña, Pablo, González-Álvarez, Marta, Merino, Virginia, Marcos, M. Dolores, Martínez-Máñez, Ramón, and Sancenón, Félix
- Subjects
- *
MESOPOROUS silica , *MESOPOROUS materials , *SODIUM dithionite , *HYDROLYSIS , *CARBAMATES , *AZO compounds - Abstract
Magnetic micro-sized mesoporous silica particles were used for the preparation of a gated material able to release an entrapped cargo in the presence of an azo-reducing agent and, to some extent, at acidic pH. The magnetic mesoporous microparticles were loaded with safranin O and the external surface was functionalized with an azo derivative 1 (bearing a carbamate linkage) yielding solid S1. Aqueous suspensions of S1 at pH 7.4 showed negligible safranin O release due to the presence of the bulky azo derivative attached onto the external surface of the inorganic scaffold. However, in the presence of sodium dithionite (azoreductive agent), a remarkable safranin O delivery was observed. At acidic pH, a certain safranin O release from S1 was also found. The pH-triggered safranin O delivery was ascribed to the acid-induced hydrolysis of the carbamate moiety that linked the bulky azo derivatives onto the mesoporous inorganic magnetic support. The controlled release behavior of S1 was also tested using a model that simulated the gastro intestinal tract. [ABSTRACT FROM AUTHOR]
- Published
- 2018
- Full Text
- View/download PDF