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8. Cytotoxic Polyketides from the Marine Sponge-Derived Fungus Pestalotiopsis heterocornis XWS03F09.

Author

Lei, Hui, Lei, Jing, Zhou, Xuefeng, Hu, Mei, Niu, Hong, Song, Can, Chen, Siwei, Liu, Yonghong, and Zhang, Dan

Subjects
POLYKETIDES, MARINE fungi, CHEMICAL structure, CIRCULAR dichroism, OPTICAL rotation, CELL lines, CANCER cells, PESTALOTIOPSIS
Abstract

Four new compounds, including two new polyketides, heterocornols M and N (1, 2), and a pair of epimers, heterocornols O and P (3, 4), were isolated from the fermentation broth of the marine sponge-derived fungus Pestalotiopsis heterocornis XWS03F09, together with three known compounds (5–7). The new chemical structures were established on the basis of a spectroscopic analysis, optical rotation, experimental and calculated electronic circular dichroism (ECD). All of the compounds (1–7) were evaluated for their cytotoxic activities, and heterocornols M-P (1–4) exhibited cytotoxicities against four human cancer cell lines with IC50 values of 20.4–94.2 μM. [ABSTRACT FROM AUTHOR]

Published
2019
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