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2 results on '"Yue-li Zou"'

1. Design, Synthesis, and Safener Activity of Novel Methyl (R)-N-Benzoyl/Dichloroacetyl-Thiazolidine-4-Carboxylates

Author

Li-Xia Zhao, Hao Wu, Yue-Li Zou, Qing-Rui Wang, Ying Fu, Chun-Yan Li, and Fei Ye

Subjects
methyl (R)-N-benzoyl/dichloroacetyl-thiazolidine-4-carboxylates, active substructure combination, safener activity, Organic chemistry, QD241-441
Abstract

A series of novel methyl (R)-N-benzoyl/dichloroacetyl-thiazolidine-4-carboxylates were designed by active substructure combination. The title compounds were synthesized using a one-pot route from l-cysteine methyl ester hydrochloride, acyl chloride, and ketones. All compounds were characterized by IR, 1H NMR, 13C NMR, and HRMS. The structure of 4q was determined by X-ray crystallography. The biological tests showed that the title compounds protected maize from chlorimuron-ethyl injury to some extent. The ALS activity assay showed that the title compounds increased the ALS activity of maize inhibited by chlorimuron-ethyl. Molecular docking modeling demonstrated that Compound 4e competed against chlorimuron-ethyl to combine with the herbicide target enzyme active site, causing the herbicide to be ineffective.

Published
2018
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2. Design, Synthesis, and Safener Activity of Novel Methyl (R)-N-Benzoyl/Dichloroacetyl-Thiazolidine-4-Carboxylates

Author

Ying Fu, Chun-Yan Li, Qing-Rui Wang, Yue-Li Zou, Hao Wu, Li-Xia Zhao, and Fei Ye

Subjects
Stereochemistry, Thiazolidine, Pharmaceutical Science, Ester hydrochloride, 01 natural sciences, Zea mays, Article, Analytical Chemistry, lcsh:QD241-441, chemistry.chemical_compound, Acyl chloride, lcsh:Organic chemistry, Drug Discovery, Cysteine, Physical and Theoretical Chemistry, methyl (R)-N-benzoyl/dichloroacetyl-thiazolidine-4-carboxylates, active substructure combination, safener activity, biology, Molecular Structure, 010405 organic chemistry, Herbicides, Organic Chemistry, Active site, Esters, Stereoisomerism, 04 agricultural and veterinary sciences, Carbon-13 NMR, Ketones, 0104 chemical sciences, Molecular Docking Simulation, Pyrimidines, Sulfonylurea Compounds, chemistry, Design synthesis, Chemistry (miscellaneous), Seeds, 040103 agronomy & agriculture, Proton NMR, biology.protein, 0401 agriculture, forestry, and fisheries, Molecular Medicine, Thiazolidines
Abstract

A series of novel methyl (R)-N-benzoyl/dichloroacetyl-thiazolidine-4-carboxylates were designed by active substructure combination. The title compounds were synthesized using a one-pot route from l-cysteine methyl ester hydrochloride, acyl chloride, and ketones. All compounds were characterized by IR, 1H NMR, 13C NMR, and HRMS. The structure of 4q was determined by X-ray crystallography. The biological tests showed that the title compounds protected maize from chlorimuron-ethyl injury to some extent. The ALS activity assay showed that the title compounds increased the ALS activity of maize inhibited by chlorimuron-ethyl. Molecular docking modeling demonstrated that Compound 4e competed against chlorimuron-ethyl to combine with the herbicide target enzyme active site, causing the herbicide to be ineffective.

Published
2018

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