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2 results on '"Sebastian Greiser"'

1. In Situ Investigation of a Self-Accelerated Cocrystal Formation by Grinding Pyrazinamide with Oxalic Acid

Author

Hannes Kulla, Sebastian Greiser, Sigrid Benemann, Klaus Rademann, and Franziska Emmerling

Subjects
in situ, cocrystal, mechanochemistry, hydrate, pyrazinamide, Organic chemistry, QD241-441
Abstract

A new cocrystal of pyrazinamide with oxalic acid was prepared mechanochemically and characterized by PXRD, Raman spectroscopy, solid-state NMR spectroscopy, DTA-TG, and SEM. Based on powder X-ray diffraction data the structure was solved. The formation pathway of the reaction was studied in situ using combined synchrotron PXRD and Raman spectroscopy. Using oxalic acid dihydrate the initially neat grinding turned into a rapid self-accelerated liquid-assisted grinding process by the release of crystallization water. Under these conditions, the cocrystal was formed directly within two minutes.

Published
2016
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2. In Situ Investigation of a Self-Accelerated Cocrystal Formation by Grinding Pyrazinamide with Oxalic Acid

Author

Klaus Rademann, Franziska Emmerling, Hannes Kulla, Sebastian Greiser, and Sigrid Benemann

Subjects
Models, Molecular, pyrazinamide, Magnetic Resonance Spectroscopy, Oxalic acid, Inorganic chemistry, Pharmaceutical Science, 02 engineering and technology, 010402 general chemistry, 01 natural sciences, Cocrystal, Article, Analytical Chemistry, law.invention, lcsh:QD241-441, symbols.namesake, chemistry.chemical_compound, lcsh:Organic chemistry, X-Ray Diffraction, law, Mechanochemistry, in situ, cocrystal, mechanochemistry, hydrate, Drug Discovery, Physical and Theoretical Chemistry, Crystallization, Oxalic Acid, Organic Chemistry, Hydrogen Bonding, Nuclear magnetic resonance spectroscopy, 021001 nanoscience & nanotechnology, 0104 chemical sciences, Grinding, chemistry, Chemistry (miscellaneous), symbols, Molecular Medicine, 0210 nano-technology, Raman spectroscopy, Powder diffraction, Nuclear chemistry
Abstract

A new cocrystal of pyrazinamide with oxalic acid was prepared mechanochemically and characterized by PXRD, Raman spectroscopy, solid-state NMR spectroscopy, DTA-TG, and SEM. Based on powder X-ray diffraction data the structure was solved. The formation pathway of the reaction was studied in situ using combined synchrotron PXRD and Raman spectroscopy. Using oxalic acid dihydrate the initially neat grinding turned into a rapid self-accelerated liquid-assisted grinding process by the release of crystallization water. Under these conditions, the cocrystal was formed directly within two minutes.

Published
2016

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