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5 results on '"Scott, Peter J. H."'

1. Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes–7

Author

Gütschow, Michael, primary, Vanden Eynde, Jean Jacques, additional, Jampilek, Josef, additional, Kang, CongBao, additional, Mangoni, Arduino A., additional, Fossa, Paola, additional, Karaman, Rafik, additional, Trabocchi, Andrea, additional, Scott, Peter J. H., additional, Reynisson, Jóhannes, additional, Rapposelli, Simona, additional, Galdiero, Stefania, additional, Winum, Jean-Yves, additional, Brullo, Chiara, additional, Prokai-Tatrai, Katalin, additional, Sharma, Arun K., additional, Schapira, Matthieu, additional, Azuma, Yasu-Taka, additional, Cerchia, Laura, additional, Spetea, Mariana, additional, Torri, Giangiacomo, additional, Collina, Simona, additional, Geronikaki, Athina, additional, García-Sosa, Alfonso T., additional, Vasconcelos, M. Helena, additional, Sousa, Maria Emília, additional, Kosalec, Ivan, additional, Tuccinardi, Tiziano, additional, Duarte, Iola F., additional, Salvador, Jorge A. R., additional, Bertinaria, Massimo, additional, Pellecchia, Maurizio, additional, Amato, Jussara, additional, Rastelli, Giulio, additional, Gomes, Paula A. C., additional, Guedes, Rita C., additional, Sabatier, Jean-Marc, additional, Estévez-Braun, Ana, additional, Pagano, Bruno, additional, Mangani, Stefano, additional, Ragno, Rino, additional, Kokotos, George, additional, Brindisi, Margherita, additional, González, Florenci V., additional, Borges, Fernanda, additional, Miloso, Mariarosaria, additional, Rautio, Jarkko, additional, and Muñoz-Torrero, Diego, additional

Published
2020
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3. Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes–6

Author

Vanden Eynde, Jean Jacques, primary, Mangoni, Arduino A., additional, Rautio, Jarkko, additional, Leprince, Jérôme, additional, Azuma, Yasu-Taka, additional, García-Sosa, Alfonso T., additional, Hulme, Christopher, additional, Jampilek, Josef, additional, Karaman, Rafik, additional, Li, Wei, additional, Gomes, Paula A. C., additional, Hadjipavlou-Litina, Dimitra, additional, Capasso, Raffaele, additional, Geronikaki, Athina, additional, Cerchia, Laura, additional, Sabatier, Jean-Marc, additional, Ragno, Rino, additional, Tuccinardi, Tiziano, additional, Trabocchi, Andrea, additional, Winum, Jean-Yves, additional, Luque, F. Javier, additional, Prokai-Tatrai, Katalin, additional, Spetea, Mariana, additional, Gütschow, Michael, additional, Kosalec, Ivan, additional, Guillou, Catherine, additional, Vasconcelos, M. Helena, additional, Kokotos, George, additional, Rastelli, Giulio, additional, de Sousa, Maria Emília, additional, Manera, Clementina, additional, Gemma, Sandra, additional, Mangani, Stefano, additional, Siciliano, Carlo, additional, Galdiero, Stefania, additional, Liu, Hong, additional, Scott, Peter J. H., additional, de los Ríos, Cristóbal, additional, Agrofoglio, Luigi A., additional, Collina, Simona, additional, Guedes, Rita C., additional, and Muñoz-Torrero, Diego, additional

Published
2019
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4. Radioanalytical Techniques to Quantitatively Assess the Biological Uptake and In Vivo Behavior of Hazardous Substances.

Author

Lee, Jae Young, Mushtaq, Sajid, Park, Jung Eun, Shin, Hee Soon, Lee, So-Young, Jeon, Jongho, Muñoz-Torrero, Diego, and Scott, Peter J. H.

Subjects
HAZARDOUS substances, HAZARDOUS substance exposure, POISONS, ANALYTICAL radiochemistry, RADIOACTIVE tracers, RADIOISOTOPES, BIOLOGICAL monitoring
Abstract

Concern about environmental exposure to hazardous substances has grown over the past several decades, because these substances have adverse effects on human health. Methods used to monitor the biological uptake of hazardous substances and their spatiotemporal behavior in vivo must be accurate and reliable. Recent advances in radiolabeling chemistry and radioanalytical methodologies have facilitated the quantitative analysis of toxic substances, and whole-body imaging can be achieved using nuclear imaging instruments. Herein, we review recent literature on the radioanalytical methods used to study the biological distribution, changes in the uptake and accumulation of hazardous substances, including industrial chemicals, nanomaterials, and microorganisms. We begin with an overview of the radioisotopes used to prepare radiotracers for in vivo experiments. We then summarize the results of molecular imaging studies involving radiolabeled toxins and their quantitative assessment. We conclude the review with perspectives on the use of radioanalytical methods for future environmental research. [ABSTRACT FROM AUTHOR]

Published
2020
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5. PET Imaging of [11C]MPC-6827, a Microtubule-Based Radiotracer in Non-Human Primate Brains.

Author

Damuka, Naresh, Czoty, Paul W., Davis, Ashley T., Nader, Michael A., Nader, Susan H., Craft, Suzanne, Macauley, Shannon L., Galbo, Lindsey K., Epperly, Phillip M., Whitlow, Christopher T., Davenport, April T., Martin, Thomas J., Daunais, James B., Mintz, Akiva, Solingapuram Sai, Kiran Kumar, Roivainen, Anne, and Scott, Peter J. H.

Subjects
RADIOACTIVE tracers, POSITRON emission tomography, KRA, PRIMATES, NEUROLOGICAL disorders, ALZHEIMER'S disease
Abstract

Dysregulation of microtubules is commonly associated with several psychiatric and neurological disorders, including addiction and Alzheimer's disease. Imaging of microtubules in vivo using positron emission tomography (PET) could provide valuable information on their role in the development of disease pathogenesis and aid in improving therapeutic regimens. We developed [11C]MPC-6827, the first brain-penetrating PET radiotracer to image microtubules in vivo in the mouse brain. The aim of the present study was to assess the reproducibility of [11C]MPC-6827 PET imaging in non-human primate brains. Two dynamic 0–120 min PET/CT imaging scans were performed in each of four healthy male cynomolgus monkeys approximately one week apart. Time activity curves (TACs) and standard uptake values (SUVs) were determined for whole brains and specific regions of the brains and compared between the "test" and "retest" data. [11C]MPC-6827 showed excellent brain uptake with good pharmacokinetics in non-human primate brains, with significant correlation between the test and retest scan data (r = 0.77, p = 0.023). These initial evaluations demonstrate the high translational potential of [11C]MPC-6827 to image microtubules in the brain in vivo in monkey models of neurological and psychiatric diseases. [ABSTRACT FROM AUTHOR]

Published
2020
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