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1. Mesoporous Silica Nanoparticles as Carriers for Intracellular Delivery of Nucleic Acids and Subsequent Therapeutic Applications

Author

Wenzhang Cha, Rengen Fan, Yufeng Miao, Yong Zhou, Chenglin Qin, Xiangxiang Shan, Xinqiang Wan, and Jinbo Li

Subjects
mesoporous silica nanoparticles, nucleic acids, drug delivery, therapeutics, Organic chemistry, QD241-441
Abstract

Nucleic acids, including DNA, microRNA (miRNA), small interfering RNA (siRNA), and antisense oligonucleotide (ASO), are powerful gene regulators, which have been demonstrated as promising drug candidates for therapeutic treatments. Nevertheless, poor cellular membrane permeability and serum stability have greatly hindered the applications of nucleic acids in biomedicine. To address these issues, associate carriers that can encapsulate and protect nucleic acids are urgently required. Mesoporous silica nanoparticles (MSNs or MSNPs), which are nanomaterials with excellent biocompatibility, large surface area for functionalization, and tunable pore size for encapsulating different cargos, are emerging as novel and ideal biomaterials for different biomedical applications. In this review paper, we focus on the applications of MSNs in nucleic acid delivery and nucleic acid-guided therapeutic treatments. General strategies for the preparation of nucleic acid-MSN complexes will be firstly introduced, followed by a summary of recent applications of MSNs in nucleic acid delivery and nucleic acid-guided therapeutics.

Published
2017
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2. Mesoporous Silica Nanoparticles as Carriers for Intracellular Delivery of Nucleic Acids and Subsequent Therapeutic Applications

Author

Xiangxiang Shan, Yufeng Miao, Cheng-Lin Qin, Xinqiang Wan, Rengen Fan, Jinbo Li, Wenzhang Cha, and Yong Zhou

Subjects
Small interfering RNA, Biocompatibility, Drug Compounding, Green Fluorescent Proteins, Pharmaceutical Science, Nanoparticle, Nanotechnology, Review, 02 engineering and technology, 010402 general chemistry, 01 natural sciences, Analytical Chemistry, lcsh:QD241-441, Mice, chemistry.chemical_compound, lcsh:Organic chemistry, Genes, Reporter, Cell Line, Tumor, Neoplasms, Drug Discovery, therapeutics, Animals, Humans, RNA, Small Interfering, Physical and Theoretical Chemistry, mesoporous silica nanoparticles, Drug Carriers, Chemistry, Organic Chemistry, Oligonucleotides, Antisense, Mesoporous silica, Silicon Dioxide, 021001 nanoscience & nanotechnology, 0104 chemical sciences, MicroRNAs, nucleic acids, Chemistry (miscellaneous), Drug delivery, drug delivery, Nucleic acid, Nanoparticles, Molecular Medicine, Surface modification, 0210 nano-technology, Porosity, DNA, HeLa Cells
Abstract

Nucleic acids, including DNA, microRNA (miRNA), small interfering RNA (siRNA), and antisense oligonucleotide (ASO), are powerful gene regulators, which have been demonstrated as promising drug candidates for therapeutic treatments. Nevertheless, poor cellular membrane permeability and serum stability have greatly hindered the applications of nucleic acids in biomedicine. To address these issues, associate carriers that can encapsulate and protect nucleic acids are urgently required. Mesoporous silica nanoparticles (MSNs or MSNPs), which are nanomaterials with excellent biocompatibility, large surface area for functionalization, and tunable pore size for encapsulating different cargos, are emerging as novel and ideal biomaterials for different biomedical applications. In this review paper, we focus on the applications of MSNs in nucleic acid delivery and nucleic acid-guided therapeutic treatments. General strategies for the preparation of nucleic acid-MSN complexes will be firstly introduced, followed by a summary of recent applications of MSNs in nucleic acid delivery and nucleic acid-guided therapeutics.

Published
2017

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