1. Recent Advances in Palladium-Catalyzed Isocyanide Insertions
- Subjects
heterocycles ,catalysis ,ARYL HALIDES ,IMIDOYLATIVE CYCLIZATION ,TERT-BUTYL ISOCYANIDE ,ARYLBORONIC ACIDS ,palladium ,ONE-POT SYNTHESIS ,LIVING POLYMERIZATION ,isocyanides ,NITROGEN-HETEROCYCLES ,insertion reactions ,CASCADE REACTIONS ,MIGRATORY INSERTION ,COUPLING REACTIONS - Abstract
Isocyanides have long been known as versatile chemical reagents in organic synthesis. Their ambivalent nature also allows them to function as a CO-substitute in palladium-catalyzed cross couplings. Over the past decades, isocyanides have emerged as practical and versatile C-1 building blocks, whose inherent N-substitution allows for the rapid incorporation of nitrogeneous fragments in a wide variety of products. Recent developments in palladium catalyzed isocyanide insertion reactions have significantly expanded the scope and applicability of these imidoylative cross-couplings. This review highlights the advances made in this field over the past eight years.
- Published
- 2020