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6 results on '"Musumeci, Francesca"'

5. Synthesis and Antibacterial Evaluation of New Pyrazolo[3,4- d ]pyrimidines Kinase Inhibitors.

Author

Greco, Chiara, Catania, Rosa, Balacco, Dario Leonardo, Taresco, Vincenzo, Musumeci, Francesca, Alexander, Cameron, Huett, Alan, Schenone, Silvia, Szöllösi, György, and Frank, Eva

Subjects
KINASE inhibitors, PROTEIN kinases, HETEROCYCLIC compounds, BACTERIAL diseases, STAPHYLOCOCCUS aureus, ERLOTINIB
Abstract

Pyrazolo[3,4-d]pyrimidines represent an important class of heterocyclic compounds well-known for their anticancer activity exerted by the inhibition of eukaryotic protein kinases. Recently, pyrazolo[3,4-d]pyrimidines have become increasingly attractive for their potential antimicrobial properties. Here, we explored the activity of a library of in-house pyrazolo[3,4-d]pyrimidines, targeting human protein kinases, against Staphylococcus aureus and Escherichia coli and their interaction with ampicillin and kanamycin, representing important classes of clinically used antibiotics. Our results represent a first step towards the potential application of dual active pyrazolo[3,4-d]pyrimidine kinase inhibitors in the prevention and treatment of bacterial infections in cancer patients. [ABSTRACT FROM AUTHOR]

Published
2020
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6. Synthesis and Antibacterial Evaluation of New Pyrazolo[3,4-d]pyrimidines Kinase Inhibitors

Author

Vincenzo Taresco, Alan Huett, Rosa Catania, Silvia Schenone, Cameron Alexander, Dario Leonardo Balacco, Chiara Greco, Francesca Musumeci, Greco, Chiara, Catania, Rosa, Leonardo Balacco, Dario, Taresco, Vincenzo, Musumeci, Francesca, Alexander, Cameron, Huett, Alan, and Schenone, Silvia

Subjects
Pyrimidine, antimicrobials, kinase inhibitors, pyrazolo[3,4-d]pyrimidines, β-lactam antibiotics, medicine.drug_class, Antibiotics, pyrazolo[3, Pharmaceutical Science, medicine.disease_cause, Analytical Chemistry, lcsh:QD241-441, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, lcsh:Organic chemistry, Ampicillin, Drug Discovery, medicine, Physical and Theoretical Chemistry, Escherichia coli, 030304 developmental biology, 0303 health sciences, Kinase, Chemistry, Global Research Theme - Health and Wellbeing, Organic Chemistry, Kanamycin, Antimicrobial, Biochemistry, Chemistry (miscellaneous), Staphylococcus aureus, 4-d]pyrimidines, 030220 oncology & carcinogenesis, Molecular Medicine, Bio/Medical/Health - Microbiology, medicine.drug
Abstract

Pyrazolo[3,4-d]pyrimidines represent an important class of heterocyclic compounds well-known for their anticancer activity exerted by the inhibition of eukaryotic protein kinases. Recently, pyrazolo[3,4-d]pyrimidines have become increasingly attractive for their potential antimicrobial properties. Here, we explored the activity of a library of in-house pyrazolo[3,4-d]pyrimidines, targeting human protein kinases, against Staphylococcus aureus and Escherichia coli and their interaction with ampicillin and kanamycin, representing important classes of clinically used antibiotics. Our results represent a first step towards the potential application of dual active pyrazolo[3,4-d]pyrimidine kinase inhibitors in the prevention and treatment of bacterial infections in cancer patients.

Published
2020
Full Text
View/download PDF

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