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2 results on '"Mircea Leabu"'

1. Helleborus purpurascens—Amino Acid and Peptide Analysis Linked to the Chemical and Antiproliferative Properties of the Extracted Compounds

Author

Adina-Elena Segneanu, Ioan Grozescu, Florentina Cziple, Daniel Berki, Daniel Damian, Cristina Mariana Niculite, Alexandru Florea, and Mircea Leabu

Subjects
antiproliferative activiy, chromatographic techniques, hellebore, thionins, mass spectroscopy, Organic chemistry, QD241-441
Abstract

There is a strong drive worldwide to discover and exploit the therapeutic potential of a large variety of plants. In this work, an alcoholic extract of Helleborus purpurascens (family Ranunculaceae) was investigated for the identification of amino acids and peptides with putative antiproliferative effects. In our work, a separation strategy was developed using solvents of different polarity in order to obtain active compounds. Biochemical components were characterized through spectroscopic (mass spectroscopy) and chromatographic techniques (RP-HPLC and GC-MS). The biological activity of the obtained fractions was investigated in terms of their antiproliferative effects on HeLa cells. Through this study, we report an efficient separation of bioactive compounds (amino acids and peptides) from a plant extract dependent on solvent polarity, affording fractions with unaffected antiproliferative activities. Moreover, the two biologically tested fractions exerted a major antiproliferative effect, thereby suggesting potential anticancer therapeutic activity.

Published
2015
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2. Helleborus purpurascens—Amino Acid and Peptide Analysis Linked to the Chemical and Antiproliferative Properties of the Extracted Compounds

Author

Alexandru Florea, Florentina Cziple, Adina-Elena Segneanu, Mircea Leabu, Ioan Grozescu, Cristina Mariana Niculite, Daniel Berki, and Daniel Damian

Subjects
antiproliferative activiy, chromatographic techniques, hellebore, thionins, mass spectroscopy, Stereochemistry, Helleborus, Pharmaceutical Science, Ranunculaceae, Helleborus purpurascens, Mass spectrometry, Article, Analytical Chemistry, HeLa, lcsh:QD241-441, chemistry.chemical_compound, lcsh:Organic chemistry, Drug Discovery, Physical and Theoretical Chemistry, chemistry.chemical_classification, Ethanol, biology, Organic Chemistry, Biological activity, biology.organism_classification, Amino acid, chemistry, Biochemistry, Chemistry (miscellaneous), Molecular Medicine
Abstract

There is a strong drive worldwide to discover and exploit the therapeutic potential of a large variety of plants. In this work, an alcoholic extract of Helleborus purpurascens (family Ranunculaceae) was investigated for the identification of amino acids and peptides with putative antiproliferative effects. In our work, a separation strategy was developed using solvents of different polarity in order to obtain active compounds. Biochemical components were characterized through spectroscopic (mass spectroscopy) and chromatographic techniques (RP-HPLC and GC-MS). The biological activity of the obtained fractions was investigated in terms of their antiproliferative effects on HeLa cells. Through this study, we report an efficient separation of bioactive compounds (amino acids and peptides) from a plant extract dependent on solvent polarity, affording fractions with unaffected antiproliferative activities. Moreover, the two biologically tested fractions exerted a major antiproliferative effect, thereby suggesting potential anticancer therapeutic activity.

Published
2015

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