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1. Delivery of Active Peptides by Self-Healing, Biocompatible and Supramolecular Hydrogels

Author

Seyedeh Rojin Shariati Pour, Sara Oddis, Marianna Barbalinardo, Paolo Ravarino, Massimiliano Cavallini, Jessica Fiori, Demetra Giuri, and Claudia Tomasini

Subjects
Franz diffusion cells, hydrogels, low-molecular-weight gelators, peptides, self-assembly, Organic chemistry, QD241-441
Abstract

Supramolecular and biocompatible hydrogels with a tunable pH ranging from 5.5 to 7.6 lead to a wide variety of formulations useful for many different topical applications compatible with the skin pH. An in vitro viability/cytotoxicity test of the gel components demonstrated that they are non-toxic, as the cells continue to proliferate after 48 h. An analysis of the mechanical properties demonstrates that the hydrogels have moderate strength and an excellent linear viscoelastic range with the absence of a proper breaking point, confirmed with thixotropy experiments. Two cosmetic active peptides (Trifluoroacetyl tripeptide-2 and Palmitoyl tripeptide-5) were successfully added to the hydrogels and their transdermal permeation was analysed with Franz diffusion cells. The liquid chromatography-mass spectrometry (HPLC-MS) analyses of the withdrawn samples from the receiving solutions showed that Trifluoroacetyl tripeptide-2 permeated in a considerable amount while almost no transdermal permeation of Palmitoyl tripeptide-5 was observed.

Published
2023
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2. Tuning Mechanical Properties of Pseudopeptide Supramolecular Hydrogels by Graphene Doping

Author

Marianna Barbalinardo, Massimiliano Cavallini, Matteo Calvaresi, Marco Montalti, Paolo Paci, Claudia Tomasini, Nicola Zanna, Demetra Giuri, Francesco Valle, Giuri D., Barbalinardo M., Zanna N., Paci P., Montalti M., Cavallini M., Valle F., Calvaresi M., and Tomasini C.

Subjects
Thixotropy, Materials science, Biocompatibility, Chemical Phenomena, Supramolecular chemistry, Pharmaceutical Science, Nanotechnology, Biocompatible Materials, Article, thixotropy, Analytical Chemistry, law.invention, Mice, Rheology, law, Drug Discovery, Spectroscopy, Fourier Transform Infrared, self-healing, Animals, Physical and Theoretical Chemistry, Mechanical Phenomena, Molecular Structure, Graphene, Phosphatidylethanolamines, Organic Chemistry, graphene, Hydrogels, Dynamic mechanical analysis, Hydrogen-Ion Concentration, Hydrogel, Chemistry (miscellaneous), Self-healing, Self-healing hydrogels, NIH 3T3 Cells, Molecular Medicine, rheology, Graphite, Peptides
Abstract

Supramolecular hydrogels, obtained from small organic molecules, may be advantageous over polymeric ones for several applications, because these materials have some peculiar properties that differentiate them from the traditional polymeric hydrogels, such as elasticity, thixotropy, self-healing propensity, and biocompatibility. We report here the preparation of strong supramolecular pseudopeptide-based hydrogels that owe their strength to the introduction of graphene in the gelling mixture. These materials proved to be strong, stable, thermoreversible and elastic. The concentration of the gelator, the degree of graphene doping, and the nature of the trigger are crucial to get hydrogels with the desired properties, where a high storage modulus coexists with a good thixotropic behavior. Finally, NIH-3T3 cells were used to evaluate the cell response to the presence of the most promising hydrogels. The hydrogels biocompatibility remains good, if a small degree of graphene doping is introduced.

Published
2019

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