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2. HPLC analysis and In Vitro and In Silico Evaluation of the Biological Activity of Polyphenolic Components Separated with Solvents of Various Polarities from Helichrysum italicum

Author

Bojilov, Dimitar, primary, Manolov, Stanimir, additional, Ahmed, Sezan, additional, Dagnon, Soleya, additional, Ivanov, Iliyan, additional, Marc, Gabriel, additional, Oniga, Smaranda, additional, Oniga, Ovidiu, additional, Nedialkov, Paraskev, additional, and Mollova, Silviya, additional

Published
2023
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5. Synthesis, In Vitro Anti-Inflammatory Activity, and HRMS Analysis of New Amphetamine Derivatives.

Author

Manolov, Stanimir, Ivanov, Iliyan, Bojilov, Dimitar, and Nedialkov, Paraskev

Subjects
*ANTI-inflammatory agents, *AMPHETAMINES, *MELTING points, *FLURBIPROFEN, *POISONS, *NONSTEROIDAL anti-inflammatory agents
Abstract

Herein, we report the obtaining of new hybrid molecules of amphetamine with different profens (amfens). The obtained amfens are characterized by their melting points, UV, 1H–, 13C–NMR, and HRMS spectra. A complete and detailed mass spectral analysis of the newly obtained derivatives of amphetamine with ibuprofen, flurbiprofen, ketoprofen, naproxen, and carprofen was performed. In vitro inhibition of albumin denaturation of each new compound was assessed, and they showed significant activity. The IC50 values of the obtained amphetamine-profen derivatives ranged from 92.81 to 159.87 µg/mL. This indicates that the new hybrids inherit the anti-inflammatory properties of profens. Using in silico method, the toxicity was also calculated. The obtained results are given in LD50 values. Depending on the route of administration, the amfens are less toxic compared to the standard amphetamine. [ABSTRACT FROM AUTHOR]

Published
2023
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