1. Cytotoxic Metabolites from the Soil-Derived Fungus Exophiala Pisciphila
- Author
-
Xiu-Kun Lin, Tian-Tian Li, Yu-Yan Zhang, Ming Liu, Hai-Zhou Liu, and Cui-Cui Wang
- Subjects
polyketide ,chromone ,indole alkaloid ,Mosher ,Exophiala pisciphila ,Organic chemistry ,QD241-441 - Abstract
A new polyketide compound 1 and a new naturally occurring chromone derivative 2, along with two known indole alkaloids 3–4 were characterized from the ethyl acetate extract of a soil-derived fungal strain, Exophiala pisciphila PHF-9. The structures of compounds 1–4 were established by detailed spectroscopic analysis and comparison with literature data. The absolute configuration of 1 was determined by a modified Mosher’s method. Compound 1 exhibited moderate cytotoxicity against A-549, Hela, PANC-28 and BEL-7402 cell lines.
- Published
- 2011
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