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2 results on '"Guangya Xiang"'

1. A Practical Route for the Preparation of 1,4,7-Triazacyclononanyl Diacetates with a Hydroxypyridinonate Pendant Arm

Author

Yongkang Gai, Zhongping Hu, Zhao Rong, Xiang Ma, and Guangya Xiang

Subjects
1,4,7-triazonane, hydroxypyridinonate, metal chelator, Organic chemistry, QD241-441
Abstract

The preparation of triazamacrocyclic hydroxypyridinonate (HOPO-TACN) derivatives as potential chelators for metals in biomedical applications was reported. The synthesis is based on a convergent synthetic approach, in which the key intermediate di-tert-butyl-2,2′-(1,4,7-triazonane-1,4-diyl) diacetate was coupled with a hydroxypyridinonate pendant arm. The method is suitable for rapid syntheses of metal chelator HOPO-TACNs of biomedical interest.

Published
2015
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2. A Practical Route for the Preparation of 1,4,7-Triazacyclononanyl Diacetates with a Hydroxypyridinonate Pendant Arm

Author

Xiang Ma, Zhongping Hu, Zhao Rong, Guangya Xiang, and Yongkang Gai

Subjects
Molecular Structure, Chemistry, Pyridines, Triazines, Organic Chemistry, Pharmaceutical Science, Chemistry Techniques, Synthetic, Bioinformatics, Metal Chelator, Combinatorial chemistry, Article, Analytical Chemistry, lcsh:QD241-441, lcsh:Organic chemistry, hydroxypyridinonate, Chemistry (miscellaneous), Drug Discovery, Molecular Medicine, 1,4,7-triazonane, Physical and Theoretical Chemistry, Triazenes, metal chelator, Chelating Agents
Abstract

The preparation of triazamacrocyclic hydroxypyridinonate (HOPO-TACN) derivatives as potential chelators for metals in biomedical applications was reported. The synthesis is based on a convergent synthetic approach, in which the key intermediate di-tert-butyl-2,2′-(1,4,7-triazonane-1,4-diyl) diacetate was coupled with a hydroxypyridinonate pendant arm. The method is suitable for rapid syntheses of metal chelator HOPO-TACNs of biomedical interest.

Published
2015
Full Text
View/download PDF

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