1. New Bioactive Peptides Identified from a Tilapia Byproduct Hydrolysate Exerting Effects on DPP-IV Activity and Intestinal Hormones Regulation After Canine Gastrointestinal Simulated Digestion
- Author
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Theysgeur, Sandy, Cudennec, Benoit, Deracinois, Barbara, Perrin, Claire, Guiller, Isabelle, Lepoudère, Anne, Flahaut, Christophe, and Ravallec, Rozenn
- Subjects
in vitro gastrointestinal digestion ,Protein Hydrolysates ,Swine ,Dipeptidyl Peptidase 4 ,In Vitro Techniques ,Cat Diseases ,Article ,Mass Spectrometry ,Gastrointestinal Hormones ,lcsh:QD241-441 ,Dogs ,lcsh:Organic chemistry ,Fish Products ,Animals ,Humans ,Dog Diseases ,Hydrolysis ,digestive, oral, and skin physiology ,DPP-IV inhibitory peptides ,Biological Transport ,Overweight ,Animal Feed ,glucagon-like peptide 1 ,cholecystokinin ,Gastrointestinal Tract ,Glucose ,Cats ,Caco-2 Cells ,Peptides ,bioactive peptides ,fish byproduct hydrolysate ,Tilapia - Abstract
Like their owners, dogs and cats are more and more affected by overweight and obesity-related problems and interest in functional pet foods is growing sharply. Through numerous studies, fish protein hydrolysates have proved their worth to prevent and manage obesity-related comorbidities like diabetes. In this work, a human in vitro static simulated gastrointestinal digestion model was adapted to the dog which allowed us to demonstrate the promising effects of a tilapia byproduct hydrolysate on the regulation of food intake and glucose metabolism. Promising effects on intestinal hormones secretion and dipeptidyl peptidase IV (DPP-IV) inhibitory activity were evidenced. We identify new bioactive peptides able to stimulate cholecystokinin (CCK) and glucagon-like peptide 1 (GLP-1) secretions, and to inhibit the DPP-IV activity after a transport study through a Caco-2 cell monolayer.
- Published
- 2021