1. Enhanced Remdesivir Analogues to Target SARS-CoV-2
- Author
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Ryuichi Majima, Tiffany C. Edwards, Christine D. Dreis, Robert J. Geraghty, and Laurent F. Bonnac
- Subjects
C-nucleoside ,antiviral ,SARS-CoV-2 ,phosphate prodrug ,Organic chemistry ,QD241-441 - Abstract
We report the short synthesis of novel C-nucleoside Remdesivir analogues, their cytotoxicity and an in vitro evaluation against SARS-CoV-2 (CoV2). The described compounds are nucleoside analogues bearing a nitrogen heterocycle as purine analogues. The hybrid structures described herein are designed to enhance the anti-CoV2 activity of Remdesivir. The compounds were evaluated for their cytotoxicity and their anti-CoV2 effect. We discuss the impact of combining both sugar and base modifications on the biological activities of these compounds, their lack of cytotoxicity and their antiviral efficacy.
- Published
- 2023
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