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Your search keyword '"Bezuglov, Vladimir"' showing total 3 results
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3 results on '"Bezuglov, Vladimir"'

2. In Vivo Targeted Metabolomic Profiling of Prostanit, a Novel Anti-PAD NO-Donating Alprostadil-Based Drug

Author

Shestakova, Ksenia M., primary, Moskaleva, Natalia E., additional, Mesonzhnik, Natalia V., additional, Kukharenko, Alexey V., additional, Serkov, Igor V., additional, Lyubimov, Igor I., additional, Fomina-Ageeva, Elena V., additional, Bezuglov, Vladimir V., additional, Akimov, Mikhail G., additional, and Appolonova, Svetlana A., additional

Published
2020
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3. ACTH(6–9)PGP Peptide Protects SH-SY5Y Cells from H 2 O 2 , tert -Butyl Hydroperoxide, and Cyanide Cytotoxicity via Stimulation of Proliferation and Induction of Prosurvival-Related Genes.

Author

Akimov, Mikhail G., Fomina-Ageeva, Elena V., Dudina, Polina V., Andreeva, Ludmila A., Myasoyedov, Nikolay F., Bezuglov, Vladimir V., Patruno, Antonia, and Pesce, Mirko

Subjects
ADRENOCORTICOTROPIC hormone, CYANIDES, GENES, NEUROPROTECTIVE agents
Abstract

Stabilized melanocortin analog peptide ACTH(6–9)PGP (HFRWPGP) possesses a wide range of neuroprotective activities. However, its mechanism of action remains poorly understood. In this paper, we present a study of the proproliferative and cytoprotective activity of the adrenocorticotropic hormone fragment 6–9 (HFRW) linked with the peptide prolyine–glycyl–proline on the SH-SY5Y cells in the model of oxidative stress-related toxicity. The peptide dose-dependently protected cells from H2O2, tert-butyl hydroperoxide, and KCN and demonstrated proproliferative activity. The mechanism of its action was the modulation of proliferation-related NF-κB genes and stimulation of prosurvival NRF2-gene-related pathway, as well as a decrease in apoptosis. [ABSTRACT FROM AUTHOR]

Published
2021
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