Search

Your search keyword '"Beatrice Russo"' showing total 2 results
Start Over Author "Beatrice Russo" Journal molecules
2 results on '"Beatrice Russo"'

1. Synthesis, Biological and In Silico Evaluation of Pure Nucleobase-Containing Spiro (Indane-Isoxazolidine) Derivatives as Potential Inhibitors of MDM2–p53 Interaction

Author

Loredana Maiuolo, Vincenzo Algieri, Beatrice Russo, Matteo Antonio Tallarida, Monica Nardi, Maria Luisa Di Gioia, Zahra Merchant, Pedro Merino, Ignacio Delso, and Antonio De Nino

Subjects
spirooxindoles, isoxazolidines, MDM2–p53 inhibition, indane derivatives, Organic chemistry, QD241-441
Abstract

Nucleobase-containing isoxazolidines spiro-bonded to an indane core have been synthesized in very good yields by regio- and diastereoselective 1,3-dipolar cycloaddition starting from indanyl nitrones and N-vinylnucleobases by using environmentally benign microwave technology. The contemporary presence of various structural groups that are individually active scaffolds of different typology of drugs, has directed us to speculate that these compounds may act as inhibitors of MDM2−p53 interaction. Therefore, both computational calculations and antiproliferative screening against A549 human lung adenocarcinoma cells and human SH-SY5Y neuroblastoma cells were carried out to support this hypothesis.

Published
2019
Full Text
View/download PDF

2. Synthesis, Biological and In Silico Evaluation of Pure Nucleobase-Containing Spiro (Indane-Isoxazolidine) Derivatives as Potential Inhibitors of MDM2–p53 Interaction

Author

Antonio De Nino, Vincenzo Algieri, Matteo Antonio Tallarida, Pedro Merino, Loredana Maiuolo, J. Ignacio Delso, Beatrice Russo, Monica Nardi, Zahra Merchant, Maria Luisa Di Gioia, European Commission, Ministerio de Economía y Competitividad (España), Gobierno de Aragón, and Ministero dell'Istruzione, dell'Università e della Ricerca

Subjects
Lung Neoplasms, spirooxindoles, In silico, Indane, Pharmaceutical Science, Adenocarcinoma of Lung, 010402 general chemistry, 01 natural sciences, Article, Analytical Chemistry, Human lung, Nucleobase, lcsh:QD241-441, Neuroblastoma cell, Neuroblastoma, chemistry.chemical_compound, lcsh:Organic chemistry, isoxazolidines, Drug Discovery, medicine, Humans, Molecule, Spiro Compounds, Mdm2 p53, Physical and Theoretical Chemistry, Microwaves, Molecular Structure, 010405 organic chemistry, Organic Chemistry, Proto-Oncogene Proteins c-mdm2, Combinatorial chemistry, Cycloaddition, 0104 chemical sciences, MDM2–p53 inhibition, indane derivatives, medicine.anatomical_structure, chemistry, A549 Cells, Chemistry (miscellaneous), Molecular Medicine, Tumor Suppressor Protein p53
Abstract

Nucleobase-containing isoxazolidines spiro-bonded to an indane core have been synthesized in very good yields by regio- and diastereoselective 1,3-dipolar cycloaddition starting from indanyl nitrones and N-vinylnucleobases by using environmentally benign microwave technology. The contemporary presence of various structural groups that are individually active scaffolds of different typology of drugs, has directed us to speculate that these compounds may act as inhibitors of MDM2-p53 interaction. Therefore, both computational calculations and antiproliferative screening against A549 human lung adenocarcinoma cells and human SH-SY5Y neuroblastoma cells were carried out to support this hypothesis., We thank the Italian Ministry of University and Scientific Research (MIUR) for a doctoral grant and the University of Calabria for financial support. We also acknowledge the MINECO and FEDER Program (Madrid, Spain, project CTQ2016-76155-R) and the Gobierno de Aragon (Zaragoza, Spain. Biological & Computational Chemistry Group. E34_R17).

Published
2019

Catalog

Books, media, physical & digital resources
See catalog results