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Your search keyword '"Alarif, Walied M."' showing total 5 results
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5 results on '"Alarif, Walied M."'

1. Monoterpene Indole Alkaloids from the Aerial Parts of Rhazya stricta Induce Cytotoxicity and Apoptosis in Human Adenocarcinoma Cells

Author

Abdul-Hameed, Zainab H., primary, Bawakid, Nahed O., additional, Alorfi, Hajer S., additional, Sobahi, Tariq R., additional, Alburae, Najla Ali, additional, Abdel-Lateff, Ahmed, additional, Elbehairi, Serag Eldin I., additional, Alfaifi, Mohammad Y., additional, Alhakamy, Nabil A., additional, and Alarif, Walied M., additional

Published
2022
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5. Isolaurenidificin and Bromlaurenidificin, Two New C15-Acetogenins from the Red Alga Laurencia obtusa.

Author

Bawakid, Nahed O., Alarif, Walied M., Alburae, Najla A., Alorfi, Hajer S., Al-Footy, Khalid O., Al-Lihaibi, Sultan S., and Ghandourah, Mohamed A.

Abstract

Chromatographic fractionation of the CH2Cl2/MeOH extract of the Red Sea red alga Laurencia obtusa gave two new hexahydrofuro[3,2-b]furan-based C15-acetogenins, namely, isolaurenidificin (1) and bromlaurenidificin (2). The chemical structures were elucidated based on extensive analyses of their spectral data. Compounds 1 and 2 showed no toxicity (LC50 > 12 mM) using Artemia salina as test organism. Both compounds showed weak cytotoxicity against A549, HepG-2, HCT116, MCF-7, and PC-3 cells, however, they exhibited a relatively potent cytotoxic activity against peripheral blood neutrophils. This can be attributed partly to induction of apoptosis. [ABSTRACT FROM AUTHOR]

Published
2017
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