Search

Your search keyword '"3-b]quinazoline"' showing total 2 results
Start Over Descriptor "3-b]quinazoline" Journal molecules
2 results on '"3-b]quinazoline"'

1. One-pot Syntheses of Fused Quinazolines by Reaction of N-(2-Cyanophenyl)chloromethanimidoyl Chloride. I. A New Synthesis of 1,3-Oxazolo- and 1,3-Oxazino[2,3-b]quinazolines

Author

Pavel Pazdera, Petr Borek, Helena Havlišová, and Hana Divišová

Subjects
N-(2-cyanophenyl)chloromethanimidoyl chloride, 3-oxazolo[2, 3-b]- quinazoline, 3-oxazino[2, 3-b]quinazoline, methanimidoyl chloride, fused quinazolines, one-pot synthesis, Organic chemistry, QD241-441
Abstract

12H-Benzo[1,3]oxazolo[2,3-b]quinazolin-12-imine (5a), 9-chloro-12Hbenzo[1,3]oxazolo[2,3-b]quinazolin-12-imine (5b), 2,3-dihydro-5H-[1,3]oxazolo[2,3-b]quinazolin-5-imine (5c), 2,3-dihydro-3,3-dimethyl-5H-[1,3]oxazolo[2,3-b]quinazolin-5-imine (5d) and 3,4--dihydro-2H,6H-[1,3]oxazino[2,3-b]quinazolin-6-imine (5e) were synthesized in a one-pot reaction of N-(2-cyanophenyl)chloromethanimidoyl chloride (1) with 2-aminophenols, 2-aminoethanol, and 3-aminopropanol in the presence of a base. The course of the reaction was controlled by the temperature and the amount of base used. N-(2-Cyanophenyl)-(2-hydroxyanilino)methanimidoyl chloride (3a), 2-chloro-3-(2-hydroxyphenyl)-3,4-dihydroquinazolin-4-imine (4a) and 6-imino-2H, 3H, 4H, 6H, 11H-1,3-oxazino[2,3-b]-5-quinazolinium chloride (6) were identified as intermediates of the one-pot process.

Published
2000
Full Text
View/download PDF

2. One-pot Syntheses of Fused Quinazolines by Reaction of N-(2-Cyanophenyl)chloromethanimidoyl Chloride. I. A New Synthesis of 1,3-Oxazolo- and 1,3-Oxazino[2,3-b]quinazolines

Author

Helena Havlišová, Pavel Pazdera, Petr Borek, and Hana Divišová

Subjects
Base (chemistry), Stereochemistry, One-pot synthesis, methanimidoyl chloride, Pharmaceutical Science, 010402 general chemistry, 01 natural sciences, Medicinal chemistry, Chloride, Analytical Chemistry, lcsh:QD241-441, chemistry.chemical_compound, lcsh:Organic chemistry, Drug Discovery, medicine, Quinazoline, one-pot synthesis, 3-b]- quinazoline, Physical and Theoretical Chemistry, chemistry.chemical_classification, 010405 organic chemistry, Chemistry, Organic Chemistry, 3-oxazolo[2, 3-b]quinazoline, 3. Good health, 0104 chemical sciences, 3-oxazino[2, Chemistry (miscellaneous), N-(2-cyanophenyl)chloromethanimidoyl chloride, Molecular Medicine, fused quinazolines, medicine.drug
Abstract

12 H -Benzo[1,3]oxazolo[2,3-b]quinazolin-12-imine ( 5a ), 9-chloro-12 H -benzo[1,3]oxazolo[2,3-b]quinazolin-12-imine ( 5b ), 2,3-dihydro-5 H -[1,3]oxazolo[2,3-b]quinazolin-5-imine ( 5c ), 2,3-dihydro-3,3-dimethyl-5 H -[1,3]oxazolo[2,3-b]quinazolin-5-imine ( 5d ) and 3,4--dihydro-2 H ,6 H -[1,3]oxazino[2,3-b]quinazolin-6-imine ( 5e ) weresynthesized in a one-pot reaction of N-(2-cyanophenyl)chloromethanimidoyl chloride ( 1 )with 2-aminophenols, 2-aminoethanol, and 3-aminopropanol in the presence of a base. Thecourse of the reaction was controlled by the temperature and the amount of base used. N -(2-Cyanophenyl)-(2-hydroxyanilino)methanimidoyl chloride ( 3a ), 2-chloro-3-(2-hydroxy-phenyl)-3,4-dihydroquinazolin-4-imine ( 4a ) and 6-imino-2 H , 3 H , 4 H , 6 H , 11 H -1,3-oxazino[2,3-b]-5-quinazolinium chloride ( 6 ) were identified as intermediates of the one-pot process. Keywords: N -(2-cyanophenyl)chloromethanimidoyl chloride, 1,3-oxazolo[2,3-b]-quinazoline, 1,3-oxazino[2,3-b]quinazoline, methanimidoyl chloride, fused quinazolines

Published
2000

Catalog

Books, media, physical & digital resources
See catalog results