1. Four New Cyclohexylideneacetonitrile Derivatives from the Hypocotyl of Mangrove (Bruguiera gymnorrhiza)
- Author
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Erwei Hao, Riming Huang, Fei Li, Cheng-Hai Gao, Xie Yan, Jiagang Deng, Du Zhengcai, Hui-Xue Huang, Wang Zhiping, Xiangxi Yi, and Hou Xiaotao
- Subjects
Hepatitis B virus ,Acetonitriles ,Pharmaceutical Science ,Biology ,Bruguiera ,Article ,Analytical Chemistry ,Hypocotyl ,lcsh:QD241-441 ,lcsh:Organic chemistry ,Cell Line, Tumor ,Drug Discovery ,Botany ,Bruguiera gymnorrhiza ,Humans ,Glycosides ,Physical and Theoretical Chemistry ,Benzofurans ,chemistry.chemical_classification ,Plant Extracts ,Organic Chemistry ,Rhizophoraceae ,Glycoside ,biology.organism_classification ,Menisdaurilide ,antiviral ,chemistry ,Chemistry (miscellaneous) ,Wetlands ,Molecular Medicine ,Mangrove ,cyclohexylideneacetonitrile derivative - Abstract
Four new cyclohexylideneacetonitrile derivatives 1-4, named menisdaurins B-E, as well as three known cyclohexylideneacetonitrile derivatives--menisdaurin (5), coclauril (6), and menisdaurilide (7)--were isolated from the hypocotyl of a mangrove (Bruguiera gymnorrhiza). The structures of the isolates were elucidated on the basis of extensive spectroscopic analysis. Compounds 1-7 showed anti-Hepatitis B virus (HBV) activities, with EC50 values ranging from 5.1 ± 0.2 μg/mL to 87.7 ± 5.8 μg/mL.
- Published
- 2015