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Your search keyword '"Mykola Zdioruk"' showing total 1 results
Start Over Author "Mykola Zdioruk" Journal molecular therapy oncolytics
1 results on '"Mykola Zdioruk"'

1. Perturbing DDR signaling enhances cytotoxic effects of local oncolytic virotherapy and modulates the immune environment in glioma

Author

Marilin S. Koch, Mykola Zdioruk, Michal O. Nowicki, Alec M. Griffith, Estuardo Aguilar-Cordova, Laura K. Aguilar, Brian W. Guzik, Francesca Barone, Paul Peter Tak, Katharina Schregel, Michael S. Hoetker, James A. Lederer, E. Antonio Chiocca, Ghazaleh Tabatabai, and Sean E. Lawler

Subjects
Cancer Research, Oncology, Molecular Medicine, Pharmacology (medical)
Abstract

CAN-2409 is a replication-deficient adenovirus encoding herpes simplex virus (HSV) thymidine kinase (tk) currently in clinical trials for treatment of glioblastoma. The expression of tk in transduced cancer cells results in conversion of the pro-drug ganciclovir into a toxic metabolite causing DNA damage, inducing immunogenic cell death and immune activation. We hypothesize that CAN-2409 combined with DNA-damage-response inhibitors could amplify tumor cell death, resulting in an improved response. We investigated the effects of ATR inhibitor AZD6738 in combination with CAN-2409

Published
2022

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