1. Enhancing arginase 2 expression using target site blockers as a strategy to modulate macrophage phenotype
- Author
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Chiara De Santi, Frances K. Nally, Remsha Afzal, Conor P. Duffy, Stephen Fitzsimons, Stephanie L. Annett, Tracy Robson, Jennifer K. Dowling, Sally-Ann Cryan, and Claire E. McCoy
- Subjects
Drug Discovery ,Molecular Medicine - Abstract
Macrophages are plastic cells playing a crucial role in innate immunity. While fundamental in responding to infections, when persistently maintained in a pro-inflammatory state they can initiate and sustain inflammatory diseases. Therefore, a strategy that reprograms pro-inflammatory macrophages toward an anti-inflammatory phenotype could hold therapeutic potential in that context. We have recently shown that arginase 2 (Arg2), a mitochondrial enzyme involved in arginine metabolism, promotes the resolution of inflammation in macrophages and it is targeted by miR-155. Here, we designed and tested a target site blocker (TSB) that specifically interferes and blocks the interaction between miR-155 and
- Published
- 2022
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