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Your search keyword '"Mathias Gugger"' showing total 2 results
Start Over Author "Mathias Gugger" Journal molecular therapy
2 results on '"Mathias Gugger"'

1. 925. Electroporation Mediated Gene Transfer of Human Interleukin-10 to Skeletal Muscle Reduces Acute Rejection in Rat Cardiac Allografts

Author

Jarosław Pieróg, Michele Genoni, Reza Tavakoli, Steven Hyde, Amiq Gazdhar, Anna Bagdannova, Ralph A. Schmid, and Mathias Gugger

Subjects
Pharmacology, Electroporation, Skeletal muscle, Gene transfer, Biology, Molecular biology, Interleukin 10, Transduction (genetics), medicine.anatomical_structure, Plasmid dna, Drug Discovery, Genetics, Cancer research, medicine, Molecular Medicine, Molecular Biology, Gene
Abstract

Background Electroporation-mediated transfer of plasmid DNA has been demonstrated to enhance gene transduction dramatically. The aim of this study was to investigate the impact of overexpression of human IL-10 (hIL-10) on acute rejection of cardiac allografts in the rat.

Published
2004

2. 512. Electroporation-Mediated Gene Transfer of Human Hepatocyte Growth Factor Reduces Bleomycin-Induced Pulmonary Fibrosis in Rats

Author

Ralph A. Schmid, Mathias Gugger, Amiq Gazdhar, Thomas Geiser, Steven Hyde, Patrick Fachinger, and Jarosław Pieróg

Subjects
medicine.medical_treatment, Bleomycin, Lung Disorder, chemistry.chemical_compound, Drug Discovery, Pulmonary fibrosis, Genetics, medicine, Molecular Biology, Pharmacology, biology, business.industry, Growth factor, Electroporation, respiratory system, medicine.disease, In vitro, chemistry, Mitogen-activated protein kinase, Immunology, Cancer research, biology.protein, Molecular Medicine, Hepatocyte growth factor, business, medicine.drug
Abstract

Background: Pulmonary fibrosis may result in respiratory failure and a poor prognosis in patients with various types of interstitial lung disorders. Hepatocyte growth factor (HGF) is a potent mitogen for alveolar epithelial cells with antiapoptotic and fibrinolytic functions, resulting in improved alveolar repair in vitro. We hypothesized that HGF may improve pulmonary fibrosis in vitro by longterm expression of HGF using electroporation-mediated, non-viral gene transfer in the bleomycin-induced lung fibrosis model.

Published
2004

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