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Start Over Author "Liliana S. Mendonça" Journal molecular therapy: nucleic acids
1 results on '"Liliana S. Mendonça"'

1. Tumor-targeted Chlorotoxin-coupled Nanoparticles for Nucleic Acid Delivery to Glioblastoma Cells: A Promising System for Glioblastoma Treatment

Author

Pedro M Costa, Ana L Cardoso, Liliana S Mendonça, Angelo Serani, Carlos Custódia, Mariana Conceição, Sérgio Simões, João N Moreira, Luís Pereira de Almeida, and Maria C Pedroso de Lima

Subjects
chlorotoxin, glioblastoma, liposome, miR-21, stable nucleic acid lipid particle, Therapeutics. Pharmacology, RM1-950
Abstract

The present work aimed at the development and application of a lipid-based nanocarrier for targeted delivery of nucleic acids to glioblastoma (GBM). For this purpose, chlorotoxin (CTX), a peptide reported to bind selectively to glioma cells while showing no affinity for non-neoplastic cells, was covalently coupled to liposomes encapsulating antisense oligonucleotides (asOs) or small interfering RNAs (siRNAs). The resulting targeted nanoparticles, designated CTX-coupled stable nucleic acid lipid particles (SNALPs), exhibited excellent features for in vivo application, namely small size (

Published
2013
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