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Start Over Author "Albrieux F" Journal molecular pharmaceutics
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2. Assessing the dual activity of a chalcone-phthalocyanine conjugate: design, synthesis, and antivascular and photodynamic properties.

Author

Tuncel S, Trivella A, Atilla D, Bennis K, Savoie H, Albrieux F, Delort L, Billard H, Dubois V, Ahsen V, Caldefie-Chézet F, Richard C, Boyle RW, Ducki S, and Dumoulin F

Subjects
Cell Line, Cell Movement drug effects, Chalcone pharmacology, Humans, Indoles pharmacology, Isoindoles, Molecular Structure, Photosensitizing Agents chemical synthesis, Singlet Oxygen metabolism, Chalcone chemistry, Indoles chemistry, Photochemotherapy methods, Photosensitizing Agents chemistry, Photosensitizing Agents pharmacology
Abstract

Photodynamic therapy (PDT) and vascular-disrupting agents (VDA) each have their advantages in the treatment of solid tumors, but also present drawbacks. In PDT, hypoxia at the center of the tumor limits conversion of molecular oxygen into singlet oxygen, while VDAs are deficient at affecting the rim of the tumor. A phthalocyanine-chalcone conjugate combining the VDA properties of chalcones with the PDT properties of phthalocyanines was designed to address these deficiencies. Its vascular targeting, photophysical, photochemical, photodynamic activities are reported herein.

Published
2013
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