1. Endogenous Docosahexaenoic Acid (DHA) Prevents Aβ1–42 Oligomer-Induced Neuronal Injury
- Author
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Yuan Tan, Huanxing Su, Peng Li, Huixia Ren, Zhe Shi, Ti-Fei Yuan, Xiaoli Yao, Chengwei He, Jing-X Kang, and Jian-Bo Wan
- Subjects
0301 basic medicine ,Docosahexaenoic Acids ,Neuroscience (miscellaneous) ,Apoptosis ,Mice, Transgenic ,Endogeny ,Biology ,Pharmacology ,Neuroprotection ,Pathogenesis ,03 medical and health sciences ,Cellular and Molecular Neuroscience ,0302 clinical medicine ,Animals ,Cerebral Cortex ,Neurons ,chemistry.chemical_classification ,Amyloid beta-Peptides ,Cell Death ,Endoplasmic reticulum ,Fatty acid ,Cadherins ,Endoplasmic Reticulum Stress ,Mice, Inbred C57BL ,030104 developmental biology ,Neurology ,chemistry ,Biochemistry ,Docosahexaenoic acid ,Protein Multimerization ,030217 neurology & neurosurgery ,Polyunsaturated fatty acid - Abstract
The intake of the polyunsaturated fatty acid docosahexaenoic acid (DHA) or n-3 fatty acid has been associated with reduced risk of Alzheimer's disease (AD) in epidemiological reports. However, the underlying mechanism remains to be elucidated. Here, we report that exogenous DHA administration could protect neurons against Aβ oligomer-induced injury both in vitro and in vivo, partly through reducing the endoplasmic reticulum (ER) stress, and preventing cell apoptosis. In transgenic fat-1 mice with enriched ω-3 fatty acids, Aβ oligomers induced fewer neuronal losses, when compared to wild-type (WT) mice. We conclude that endogenous DHA are neuroprotective in pathogenesis processes of AD.
- Published
- 2015