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Start Over Author "Jens V. Andersen" Journal molecular neurobiology
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2. Divergent Cellular Energetics, Glutamate Metabolism, and Mitochondrial Function Between Human and Mouse Cerebral Cortex

Author

Emil W, Westi, Emil, Jakobsen, Caroline M, Voss, Lasse K, Bak, Lars H, Pinborg, Blanca I, Aldana, and Jens V, Andersen

Subjects
Cerebral Cortex, Mammals, Glucose, Glutamine, Astrocytes, Animals, Humans, Glutamic Acid, Energy Metabolism, Mitochondria
Abstract

Disruptions of brain energy and neurotransmitter metabolism are associated with several pathological conditions including neurodegenerative diseases such as Alzheimer's disease. Transgenic rodent models, and in vitro preparations hereof, are often applied for studying pathological aspects of brain metabolism. However, despite the conserved cerebral development across mammalian species, distinct differences in cellular composition and structure may influence metabolism of the rodent and human brain. To address this, we investigated the metabolic function of acutely isolated brain slices and non-synaptic mitochondria obtained from the cerebral cortex of mice and neurosurgically resected neocortical tissue of humans. Utilizing dynamic isotope labeling with

Published
2022

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