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Your search keyword '"Thorens, Bernard"' showing total 12 results
Start Over Author "Thorens, Bernard" Journal molecular metabolism
12 results on '"Thorens, Bernard"'

7. Laser capture microdissection of human pancreatic islets reveals novel eQTLs associated with type 2 diabetes

Author

Khamis, Amna, Canouil, Mickaël, Siddiq, Afshan, Crouch, Hutokshi, Falchi, Mario, Bulow, Manon von, Ehehalt, Florian, Marselli, Lorella, Distler, Marius, Richter, Daniela, Weitz, Jürgen, Bokvist, Krister, Xenarios, Ioannis, Thorens, Bernard, Schulte, Anke M., Ibberson, Mark, Bonnefond, Amelie, Marchetti, Piero, Solimena, Michele, and Froguel, Philippe

Published
2019
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8. Molecular phenotyping of multiple mouse strains under metabolic challenge uncovers a role for Elovl2 in glucose-induced insulin secretion

Author

Cruciani-Guglielmacci, Céline, Bellini, Lara, Denom, Jessica, Oshima, Masaya, Fernandez, Neïké, Normandie-Levi, Priscilla, Berney, Xavier P., Kassis, Nadim, Rouch, Claude, Dairou, Julien, Gorman, Tracy, Smith, David M., Marley, Anna, Liechti, Robin, Kuznetsov, Dmitry, Wigger, Leonore, Burdet, Frédéric, Lefèvre, Anne-Laure, Wehrle, Isabelle, Uphues, Ingo, Hildebrandt, Tobias, Rust, Werner, Bernard, Catherine, Ktorza, Alain, Rutter, Guy A., Scharfmann, Raphael, Xenarios, Ioannis, Le Stunff, Hervé, Thorens, Bernard, Magnan, Christophe, and Ibberson, Mark

Published
2017
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12. The role of sodium-coupled glucose co-transporter 3 in the satiety effect of portal glucose sensing

Author

Delaere Fabien, Duchampt Adeline, Mounien Lourdes, Seyer Pascal, Duraffourd Céline, Zitoun Carine, Thorens Bernard, and Mithieux Gilles

Subjects
0303 health sciences, medicine.medical_specialty, biology, Phlorizin, Brief Report, digestive, oral, and skin physiology, Glucose transporter, 030209 endocrinology & metabolism, Cell Biology, Carbohydrate metabolism, Glucagon-like peptide-1, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Endocrinology, chemistry, Internal medicine, Anorectic, medicine, biology.protein, GLUT2, Glucose homeostasis, TRPM5, Molecular Biology, 030304 developmental biology
Abstract

Portal vein glucose sensors detect variations in glycemia to induce a nervous signal that influences food intake and glucose homeostasis. Previous experiments using high infusions of glucose suggested a metabolic sensing involving glucose transporter 2 (GLUT2). Here we evaluated the afferent route for the signal and candidate molecules for detecting low glucose fluxes. Common hepatic branch vagotomy did not abolish the anorectic effect of portal glucose indicating dorsal transmission. GLUT2 null mice reduced their food intake in response to portal glucose signal initiated by protein enriched diet. A similar response of Trpm5 null mice and portal infusions of sweeteners also excluded sugar taste receptors. Conversely infusions of alpha methylglucose but not 3 O methylglucose decreased food intake while phlorizin prevented the effect of glucose. This suggested sensing through SGLT3 which was expressed in the portal area. From these results we propose a finely tuned dual mechanism for portal glucose sensing that responds to different physiological conditions. © 2012 Elsevier GmbH.

Published
2012

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