1. JNK signaling is required for the MIP-1α-associated regulation of Kupffer cells in the heat stroke response
- Author
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Guo‑Guo Zhu, Qing Cheng, Hui‑Min Li, Qi‑Ping Lu, Wei Fu, Wen‑Kai Zhang, Zhong‑Zhi Tang, and Xiao‑Juan Chen
- Subjects
Male ,0301 basic medicine ,Cancer Research ,Chemokine ,Kupffer Cells ,Interleukin-1beta ,Kupffer cell ,Inflammation ,Biochemistry ,Proinflammatory cytokine ,03 medical and health sciences ,0302 clinical medicine ,heat stroke ,Genetics ,medicine ,Animals ,Macrophage ,Rats, Wistar ,Interleukin 6 ,Molecular Biology ,Cells, Cultured ,c-Jun N-terminal kinase ,Chemokine CCL3 ,Liver injury ,biology ,Interleukin-6 ,Tumor Necrosis Factor-alpha ,JNK Mitogen-Activated Protein Kinases ,macrophage inflammatory protein 1α ,Interleukin ,Articles ,medicine.disease ,030104 developmental biology ,Oncology ,030220 oncology & carcinogenesis ,Immunology ,biology.protein ,Cancer research ,Molecular Medicine ,Tumor necrosis factor alpha ,medicine.symptom ,Heat-Shock Response ,Signal Transduction - Abstract
Severe heat stroke (HS) consists of extreme hyperthermia with thermoregulatory failure, leading to high morbidity and mortality. Liver injury is a complication of HS that is associated with inflammatory responses and Kupffer cells (KCs), which are resident macrophages in the liver that serve as a major source of inflammatory cytokines; however, the association and the underlying mechanisms of KC functions in HS-induced endotoxemia and inflammation require an improved understanding. The important chemokine macrophage inflammatory protein-1α (MIP-1α) increases inflammatory responses and the secretion of inflammatory molecules from KCs, including tumor necrosis factor-α, interleukin (IL)-1β and IL-6. In addition, the activation of c-Jun N-terminal kinase (JNK) signaling is responsible for the development of liver inflammation. Therefore, HS animal and cell models were constructed in order to investigate the pathways involved in the HS-induced dysfunction of KCs. The results of the present study suggest that JNK may be involved in the MIP-1α-associated pathogenesis of KCs in HS injury.
- Published
- 2017
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