1. Role of epithelial chemokines in the pathogenesis of airway inflammation in asthma (Review)
- Author
-
Xun Zhang, Xiangping Qu, Jianxin Jiang, Chi Liu, Huijun Liu, Xiaoqun Qin, Cai-Xia Liu, Mei-Ling Tan, and Yang Xiang
- Subjects
0301 basic medicine ,Cancer Research ,Chemokine ,Thymic stromal lymphopoietin ,Neutrophils ,Cell ,Respiratory Mucosa ,Biochemistry ,Monocytes ,Pathogenesis ,03 medical and health sciences ,0302 clinical medicine ,Genetics ,Medicine ,Animals ,Humans ,Molecular Biology ,Asthma ,Inflammation ,biology ,Oncogene ,business.industry ,respiratory system ,Cell cycle ,medicine.disease ,respiratory tract diseases ,Eosinophils ,030104 developmental biology ,medicine.anatomical_structure ,Oncology ,Immunology ,biology.protein ,Molecular Medicine ,Chemokines ,business ,Airway ,030215 immunology - Abstract
As the first barrier to the outside environment, airway epithelial cells serve a central role in the initiation and development of airway inflammation. Chemokines are the most direct and immediate cell factors for the recruitment and migration of inflammatory cells. The present review focused on the role of epithelial chemokines in the pathogenesis of airway inflammation in asthma. In addition to traditional CC family chemokines and CXC family chemokines, airway epithelial cells also express other chemokines, including thymic stromal lymphopoietin and interleukin‑33. By expressing and secreting chemokines, airway epithelial cells serve a key role in orchestrating airway inflammation in asthma.
- Published
- 2017